Results 111 to 120 of about 25,089 (208)

Genetic analysis of the human cytochrome P450 CYP2C9 locus

, 1996
Cytochrome P450 CYP2C9 metabolizes a wide variety of clinically important drugs, including phenytoin, tolbutamide, warfarin and a large number of non-steroidal anti-inflammatory drugs. Previous studies have shown that even relatively conservative changes
Tarbit, Michael H, Wolf, C Roland, Stubbins, Michael J, Harries, Lorna W, Smith, Gillian; id_orcid   +4 more
core   +2 more sources

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, Volume 13, Issue 53, 24 September 2026.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Cytochrome P450-Catalyzed Hydroxylation of Δ8-Tetrahydrocannabinol and Implications for Pharmacogenetics

Pharmaceutics
Introduction: The use of Δ8-tetrahydrocannabinol (Δ8-THC) has become increasingly prevalent in the United States, but its metabolic pathways remain poorly characterized.
Mengqi Zhao, Philip Lazarus
doaj   +1 more source

N‐(1H‐Indazolyl) Aryl Sulfonamide Hybrids as Potential Dihydropteroate Synthase Inhibitors: In Vitro Antibacterial Activity Against Escherichia coli and Staphylococcus aureus and Computational Modeling

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Sixteen indazole–sulfonamide hybrids exhibit species‐dependent antibacterial activity against E. coli and S. aureus, with the lead compound displaying an eightfold lower MIC than sulfathiazole against E. coli. Molecular docking against wild‐type and Sul1‐resistant dihydropteroate synthase identifies a candidate retaining binding affinity toward the ...
Romaisaa Boudza, Ferdaous Elandaloussi, Khalid Boujdi, Jaume Segura‐Garcia, Nabil El Brahmi, Saïd El Kazzouli, Ismaïl Moukadiri, Sergi Maicas, Salim Bounou   +8 more
wiley   +1 more source

Distribution of polymorphisms in the CYP2C9 gene and CYP2C19/CYP2C9 haplotypes among Venezuelan populations

, 2017
Background: Polymorphisms with decreased enzyme activity of their gene products have been reported in region CYP2C with population variations in haplotype structure. Aim: To estimate the allelic and genotypic frequencies of variants CYP2C9*2 and CYP2C9*3
Sara Flores-Gutiérrez, Dinorah Castro de Guerra, Álvaro Rodríguez-Larralde, Merlyn Vívenes de Lugo   +3 more
core   +1 more source

GC–MS‐Based Phytochemical Profiling and Integrated Evaluation of Antioxidant, Antibacterial, and In Silico Studies of Kumaun Himalayan Strobilanthes Species

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Himalayan Strobilanthes species: phytochemical profiling, bioactivities, and In silico Studies. ABSTRACT Five Strobilanthes species indigenous to the Kumaun Himalayan region of Uttarakhand, India, have been historically employed in traditional medicine to treat bacterial infections, inflammatory conditions, and respiratory ailments, but remain largely ...
Sakshi Negi, Ravendra Kumar, Vaishnavi Rawat, Pooja Bargali, Aashish Kumar Sagar, Stefania Garzoli, Riddhiman Lahiri, Shilpi Rawat, Avdhesh Kumar, Manmohan Singh Rawat, Jolanta Maslowiecka, Valery A. Isidorov, Dharmendra S. Rawat   +12 more
wiley   +1 more source

Pharmacogenetic polymorphisms of CYP2C9 in population of East Croatia

, 2020
CILJ ISTRAŽIVANJA: Genotipizacija farmakogenetičkih polimorfizama rs1799853 (*2) i rs1057910 (*3) gena CYP2C9 i određivanje učestalosti alelnih varijanti i genotipova CYP2C9 u populaciji istočne Hrvatske. NACRT STUDIJE: Presječno istraživanje. ISPITANICI
Skaramuca, Iva
core   +1 more source

Essential Oil Compositions and Biological Activities of Broussonetia papyrifera Aerial Parts: An Integrated In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Essential oils from B. papyrifera stem bark and leaves were characterized by a high abundance of oxygenated sesquiterpenes, particularly spathulenol and (Z)‐dihydro‐apofarnesol. Both essential oils exhibited antioxidant and anti‐inflammatory activities, along with moderate cytotoxic effects.
Ty Viet Pham, Nguyen Thi Thoa, Nguyen Thi Huong, Le The Hoai, Tran Quang Hai, Shaza W. Shantier, Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Vo Thi Dung, Ninh The Son   +10 more
wiley   +1 more source

Evaluation of CYP2C8 and CYP2C9 Polymorphisms in Neonates with Patent Ductus Arteriosus Treated with Ibuprofen or Indomethacin: A Retrospective Cohort Study

Journal of Cardiovascular Development and Disease
The pharmacologic management of patent ductus arteriosus (PDA) presents a challenge to clinicians due to the interindividual variability in drug response to available medications.
Shaikha Jabor Alnaimi, Shimaa Aboelbaha, Ibrahim Safra, Mai Abdulla Al Qubaisi, Fouad Abounahia, Ahmed Al Farsi, Liji Cherian, Lizy Philip, Moza Alhail, Gulab Sher, Nader Al-Dewik   +10 more
doaj   +1 more source

Phytochemical Profiling and Biological Evaluation of Pistacia lentiscus L. grown in Chlef (Algeria): An Integrated In Vitro, In Vivo, and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The antihypoxic and antioxidant activities of Pistacia lentiscus L. extract are assessed. High total phenolics and flavonoids contents are noted. Various phenolic acids and flavonoids are identified via HPLC‐MS analysis. The extract demonstrates important scavenging and reducing power, enhances mice survival under normobaric hypoxia, and reduces ...
Halima Saiah, Ali Zineddine Boumehira, Wassila Saiah, Salima Boudane, Asma Al‐farajein   +4 more
wiley   +1 more source