Results 71 to 80 of about 37,178 (276)

Genotype of cytochrome-450 2C9 in patients with tuberculosis [PDF]

Medičnì Perspektivi, 2013
The aim of present work was to investigate CYP2С9 polymorphism in the south of Ukraine in TB-patients and comparing with the same data of control group by the example of Odessa region. Gene CYP2С9 polymorphism was studied with the help of PCR (polymerase
Kresyun V.I., Filyuk V.V., Antonenko P.B., Rogach K.K., Danylenko Yu.M., Mozolevych G.V.   +5 more
doaj  

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. [PDF]

, 2016
The endoplasmic reticulum (ER)-anchored hepatic cytochromes P450 (P450s) are enzymes that metabolize endo- and xenobiotics i.e. drugs, carcinogens, toxins, natural and chemical products.
Correia, Maria Almira, Kim, Sung-Mi, Liu, Yi, Nabavi, Noushin, Wang, YongQiang   +4 more
core   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Mycobacterium avium subspecies paratuberculosis bacteremia in type 1 diabetes mellitus: an infectious trigger? [PDF]

, 2008
Mycobacterium avium subspecies paratuberculosis (MAP) is the established cause of paratuberculosis in ruminants (i.e., Johne disease). The bacterium is shed in the milk of infected cows and survives pasteurization.
Paccagnini, Daniela, Salza, Sara, Sechi, Leonardo Antonio   +2 more
core  

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group [PDF]

, 2018
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease.
Avery, C.L., Bis, J.C., Brody, J.A., Broer, L., Busch, E.L., Chen, Y.-DI., Cummings, S.R., Cupples, L.A., de Mutsert, R., Duan, Q., Eicher, J.D., Evans, D.S., Floyd, J.S., Gogarten, S.M., Gudnason, V., Harris, T.B., Heckbert, S.R., Johnson, A.D., Jukema, J.W., Kaplan, R.C., Kerr, K.F., Kors, J.A., Lange, L.A., Launer, L.J., Laurie, C.C., Li, J., Li, X., Li, Y., Li-Gao, R., Lin, H.J., Liu, Y., Mook-Kanamori, D.O., Méndez-Giráldez, R., Napier, M.D., Noordam, R., Psaty, B.M., Reiner, A.P., Rice, K.M., Roach, J., Rosendaal, F.R., Rotter, J.I., Sattar, N., Seyerle, A.A., Sitlani, C.M., Slagboom, P.E., Smith, A.V., Soliman, E.Z., Sotoodehnia, N., Stewart, J.D., Stott, D.J., Stricker, B.H., Stürmer, T., Taylor, K.D., Trompet, S., Uitterlinden, A.G., Whitsel, E.A., Wiggins, K.L., Wilhelmsen, K.C., Wilson, J.G.   +58 more
core   +4 more sources

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

DISTRIBUTION OF POLYMORPHISMS OF GENES OF STATINS METABOLISM AND TRANSPORT IN THE LIVER IN PATIENTS WITH CORONARY ARTERY DISEASE ETHNIC UZBEKS WITH SIMVASTATIN INTOLERANCE

Евразийский Кардиологический Журнал, 2017
Background. It is well-known that in majority of cases treatment with statins can be safe and well tolerated, but in some patients observed statin-induced adverse liver or muscle symptoms - the main reasons for statin discontinuation.
A. B. Shek, R. D. Kurbanov, G. J. Abdullayeva, A. V. Nagai, A. A. Abdullaev, S. S. Ahmedova, S. U. Hoshimov, A. V. Ziyaeva   +7 more
doaj   +1 more source

Clinical considerations in transitioning patients with epilepsy from clonazepam to clobazam: a case series. [PDF]

, 2014
IntroductionIn treating refractory epilepsy, many clinicians are interested in methods used to transition patients receiving clonazepam to clobazam to maintain or increase seizure control, improve tolerability of patients' overall drug therapy regimens ...
Chung, Steve, Kuzniecky, Ruben, Perry, Michael Scott, Sankar, Raman, Sinha, Saurabh   +4 more
core   +1 more source