Results 111 to 120 of about 2,707,171 (199)
Possible impact of human CYP2E1 polymorphisms on the metabolism of acrylonitrile
, 2002 Case reports of human accidental poisonings point to significant individual differences in human acrylonitrile metabolism and toxicity. A cohort of 59 persons with industrial handling of low levels of acrylonitrile has repetitively been studied from 1994
Selinski, S +11 more
core +1 more source
CYP2E1 and oxidative liver injury by alcohol
, 2008 Ethanol-induced oxidative stress appears to play a major role in mechanisms by which ethanol causes liver injury. Many pathways have been suggested to contribute to the ability of ethanol to induce a state of oxidative stress. One central pathway appears
Cederbaum, Arthur I., Lu, Yongke
core
Role of CYP2E1 in the hepatotoxicity of acetaminophen.
, 1996 CYP2El, a cytochrome P-450 that is well conserved across mammalian species, metabolizes ethanol and many low molecular weight toxins and cancer suspect agents.
Lee, SS;Buters, JT;Pineau, T;Fernandez-Salguero, P;Gonzalez, FJ
core +1 more source
Romidepsin (FK228) in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury is Associated with Down-Regulation of the CYP2E1 Gene. [PDF]
Med Sci Monit, 2020 Cheng S, Wu T, Li Y, Huang J, Cai T.
europepmc +1 more source
Gene expression of CYP2E1 in the male germ line.
, 2014 Q-PCR analysis of CYP2E1 mRNA expression in mouse testis at different developmental stages 2, 6, 11, 14, 18, 22, and 36 d after birth, and adult (older than 56 d). Expression was also examined in isolated male germ cells, spermatogonia, spermatocytes and
John E. Schjenken (558844) +5 more
core +1 more source
Revista de biologia tropical, 2004 Las enzimas de las familias P450 y Glutation Stransferasa están relacionadas en la activación y desintoxicación de sustancias que podrían actuar como cancerígenas. Polimorfismos genéticos en estas enzimas han sido asociados con un incremento en el riesgo de desarrollar cáncer específicamente con un mayor riesgo de desarrollar cáncer gástrico.
González, Auxiliadora +3 more
openaire +2 more sources
Chemical characteristics for optimizing CYP2E1 inhibition
, 2015 Cytochrome P450 2E1 (CYP2E1) expression and activity in the liver is associated with the degree of liver damage in patients with alcoholic steatohepatitis (ASH) as well as non-alcoholic steatohepatitis (NASH).
Koek, G.H. +4 more
core +1 more source
CYP2E1 and ALDH2 Gene Polymorphisms in Squamous Cell Head and Neck
, 2019 Alcohol consumption and smoking habits are risk-enhancing factors for head and neck squamous cell carcinoma (HNSCC). The CYP450 2E1 (CYP2E1) and acetaldehyde dehydrogenase 2 (ALDH2) enzymes play an important role in the metabolism of these carcinogens.
Karakoc, MD +3 more
openaire
Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants
Genetics and Molecular Biology, 2009 Individual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. Genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene ...
Marcos Euzébio Maciel +5 more
doaj