Results 91 to 100 of about 2,707,171 (199)

Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription

International Journal of Molecular Medicine, 2016
Acute liver failure, i.e., the fatal deterioration of liver function, is the most common indication that emergency liver transplantation is necessary. Moreover, in the USA, drug-induced liver injury (DILI), including acetaminophen (APAP)-induced hepatotoxicity, is the main cause of acute liver failure.
PARK, WOO-JAE, KIM, SO-YEON, KIM, YE-RYUNG, PARK, JOO-WON   +3 more
openaire   +3 more sources

Alcoholic Liver Disease: from CYP2E1 to CYP2A5

, 2017
This article reviews recent studies on CYP2E1-mediated alcoholic liver injury, the induction of CYP2A5 by alcohol and the mechanism for this upregulation, especially the permissive role of CYP2E1 in the induction of CYP2A5 by alcohol and the CYP2E1-ROS ...
Leung, Tung Ming, Lu, Yongke, Leung, Tung M., Tung Ming Leung, Yongke Lu   +4 more
core   +1 more source

Unraveling the Role of CYP2E1 in Antitubercular Drug–Induced Hepatotoxicity: From Molecular Mechanisms to Clinical Implications

International Journal of Hepatology
Antitubercular (AT) drugs, particularly isoniazid (INH), rifampicin (RIF), pyrazinamide (PYZ), and ethambutol (EMB), are the cornerstone of tuberculosis (TB) treatment.
Debasree Bishnu, Suman Santra, Swagata Purkait, Amal Santra   +3 more
doaj   +1 more source

CYP2E1 and ALDH2 gene polymorphisms in squamous cell head and neck cancer in the Turkish population

, 2019
Alcohol consumption and smoking habits are risk-enhancing factors for head and neck squamous cell carcinoma (HNSCC). The CYP450 2E1 (CYP2E1) and acetaldehyde dehydrogenase 2 (ALDH2) enzymes play an important role in the metabolism of these carcinogens ...
Karakoç, Metin Deniz, Topuz, Bülent, Kortunay, Selim, Kara, Cüneyt Orhan   +3 more
core   +1 more source

CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis

Systematic Reviews, 2018
Background Treatment with anti-tuberculosis drugs may cause patients to experience serious adverse effects. Genetic factors, such as polymorphisms of CYP genes, may increase the likelihood of a patient experiencing such adverse drug reactions.
Marty Richardson, Jamie Kirkham, Kerry Dwan, Derek J. Sloan, Geraint Davies, Andrea L. Jorgensen   +5 more
doaj   +1 more source

CYP2D6 and CYP2E1 Gene Polymorphisms and their Association with Cervical Cancer Susceptibility: A Hospital Based Case-Control Study from South-Western Maharashtra. [PDF]

Asian Pac J Cancer Prev, 2022
Datkhile KD, Durgawale PP, Gudur RA, Gudur AK, Patil SR.   +4 more
europepmc   +1 more source

Adrenergic blocker terazosin potentially suppresses acetaminophen induced-acute liver injury in animal models via CYP2E1 gene. [PDF]

Toxicol Res, 2022
Hashmat Z, Channa IS, Safdar M, Ozaslan M, Saeed M, Siddique F, Junejo Y.   +6 more
europepmc   +1 more source

Identification of deletions and duplications in the CYP2E1 gene in a population in Goiânia – GO by MLPA.

Semina: Ciências Biológicas e da Saúde, 2018
Human CYPs are important in physiology, drug metabolism, and pathogenesis of certain diseases, and there is a strong need to explore the genetic variations and regulatory mechanisms of these enzymes. Mutations in CYP genes leading to deficiency in the enzymes result in a wide spectrum of human diseases.
Lucas Carlos Gomes Pereira, Nádia Aparecida Bérgamo, Elisângela de Paula Silveira-Lacerda   +2 more
openaire   +1 more source

The genetic profiles of CYP1A1, CYP1A2 and CYP2E1 enzymes as susceptibility factor in xenobiotic toxicity in Turkish population

Saudi Pharmaceutical Journal, 2017
Evaluation and sequencing of heritable alterations in the human genome and the large-scale identification of gene polymorphism for understanding the genetic background of individuals in response to potential toxicants are provided by toxicogenetics ...
Merve Arici, Gül Özhan
doaj   +1 more source

Fast CYP2E1 genotyping using automated fluorescent detection

, 2006
BACKGROUND: Among polymorphic genes coding for xenobiotic-metabolizing enzymes, the ethanol-inducible CYP2E1 gene (1667 bp) is known to play a major role in the metabolism ofseveral chemicals.
MANTOVANI, VILMA, VIOLANTE, FRANCESCO SAVERIO, Cerreta V., ACCORSI, ANTONIO, Innocenti C.   +4 more
core