Results 71 to 80 of about 2,707,171 (199)

Relevance of CYP2E1 to non-alcoholic fatty liver disease

, 2013
Non-alcoholic fatty liver disease (NAFLD) and its progression to steatohepatitis (NASH) and cirrhosis is a growing problem in most developed countries.
Daly AK, Ann K. Daly
core   +2 more sources

Iodized Garlic Extract Regulates Stress Responses in Epidermal Keratinocytes via the Transcription Factor Nrf2

Journal of Cosmetic Dermatology, Volume 25, Issue 11, November 2026.
ABSTRACT Objective Garlic exerts protective effects against skin stress, including oxidative damage and trauma. Iodized garlic extract (IGEx) is a cosmetic ingredient developed through iodination of garlic odor components to achieve odor reduction. Although IGEx is expected to exhibit skin stress protection properties similar to garlic, the molecular ...
Yuki Miyauchi, Natsumi Iwasaki, Liangjing Xie, Satoshi Yano, Taichi Hara   +4 more
wiley   +1 more source

HNF-4α plays a critical role in CYP2E1 gene expression.

, 2014
(A) A schematic depiction of different human CYP2E1 promoter regions cloned into the pGL3-basic plasmid. The constructs were designated as CPY2E1-P-luc and its various deletion constructs CPY2E1-P1-luc to -P10.
Xiaodong Wang (66801), Guiyu Lou (157864), Lixia Gan (631936), Chongyi Li (631934), Bin Xie (234992), Hongming Liu (631933), Arthur I. Cederbaum (631935)   +6 more
core   +1 more source

Study of Cytochrome P450 2E1 and its allele Variants in Liver Injury of Nondiabetic, Nonalcoholic Steatohepatitis Obese Women

Biological Research, 2008
CYP2E1 enzyme is related to nonalcoholic steatohepatitis (NASH) due to its ability for reactive oxygen species production, which can be influenced by polymorphisms in the gene.
NELSON M VARELA, LUIS A QUIÑONES, MYRIAM ORELLANA, JAIME PONIACHIK, ATTILA CSENDES, GLADYS SMOK, RAMÓN RODRIGO, DANTE D CÁCERES, LUIS A VIDELA   +8 more
doaj  

Expert Consensus on the Standardized Diagnosis, Treatment, and Management of Cancer in High‐Altitude Regions of China

Cancer Innovation, Volume 5, Issue 5, October 2026.
This expert consensus establishes standardized diagnostic, therapeutic, and management frameworks for cancers in high‐altitude regions of China, addressing epidemiological characteristics, tailored treatments, and highland‐specific adverse events to optimize care for plateau populations.
Yiqun Li, Feng Li, Xiaorong Bai, Yan Li, Chengyun Bai, Qiaomei Chang, Cuiping Guo, Ji Di, Qiuxia Dong, Mengting Da, Zhongcheng Li, Zhen Liu, Hongxia Liang, Yushuang Luo, Dengfeng Ren, Pengjie Yu, Rui Ma, Miaozhou Wang, Xueshan Zhao, Fuxing Zhao, Guoshuang Shen, Zhiping Feng, Hao Wang, Shengtao Zhou, Wenqiang Wei, Shanshan Chen, Lin Wang, Feng Du, Tseyang, Haifeng Xu, Xiaoling Ling, Gang Xu, Wei Guo, Yulan Zhao, Die Sang, Huachao Feng, Deqingwangmu, Gesangdeji, Basangdunzhu, Bianbazhaxi, Yixin Guo, Xinlong Tao, Guohui Bai, Wanpeng Yang, Hanhuan Luo, Yanming Lei, Cidanwangjiu, Fei Ma, Dong Wu, Jiuda Zhao   +49 more
wiley   +1 more source

Disadvantaged induction of gene mutations by lower chlorinated biphenyls in V79-derived cells co-expressing mouse relative to human CYP2E1, molecular docking/dynamics studies suggesting unfavored metabolic activation by the mouse enzyme

Ecotoxicology and Environmental Safety
Polychlorinated biphenyls (PCBs) are persistent organic pollutants with multiple toxic effects, including mutagenicity and carcinogenicity. Some lower chlorinated biphenyls (L-CBs) may be mutagenic following activation by human CYPs, such as CYP2E1 for a
Yuyi Luo, Keqi Hu, Hongwei Tu, Ke Xu, Shunda Zhu, Lin Wang, Yungang Liu   +6 more
doaj   +1 more source

Association of CYP7A1 and CYP2E1 Polymorphisms with Type 2 Diabetes in the Chinese Han Populations

Pharmacogenomics and Personalized Medicine, 2022
Lihong Zhang, Jingjing Tang, Yindi Wang, Xiang Wang, Fang Wang Department of Endocrinology, Xi’an Central Hospital Affiliated to Xi’an Jiaotong University, Xi’an, 710003, People’s Republic of ChinaCorrespondence: Fang Wang, Department of Endocrinology ...
Zhang L, Tang J, Wang Y, Wang X, Wang F
doaj  

mRNA Expression of CYP2E1, CYP2A19, CYP1A2, HSD3B, SULT1A1 and SULT2A1 genes in surgically castrated, immunologically castrated, entire male and female pigs and correlation with androstenone, skatole, indole and Improvac-specific antibody levels

Czech Journal of Animal Science, 2019
This study aimed to obtain a comprehensive look at the influence of castration on mRNA expression of the genes CYP2E1, CYP1A2, CYP2A19, HSD3B, SULT2A1 and SULT1A1 and their correlation with boar taint compounds (androstenone, skatole and indole) and ...
Anna Kubešová, Kamil Šťastný, Martin Faldyna, Zbyšek Sládek, Iva Steinhauserová, Gabriela Bořilová, Aleš Knoll   +6 more
doaj   +1 more source

CDS2 Drives Tumor Progression in Epithelial Ovarian Cancer via the PI3K/AKT Pathway

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Epithelial ovarian cancer (EOC) frequently disseminates within the lipid‐rich peritoneal cavity, where tumor progression is accompanied by metabolic adaptations involving lipid utilization and mitochondrial function. Although these metabolic alterations are increasingly recognized as important features of EOC progression and ...
Lixue Cao, Yanzhen Chen, Yingqi Liu, Changnian Yang, Zhentao Zhang, Yongqing Lin, Yiyuan Wang, Siman Chen, Fei Yu, Haiyan Ye, Shanshan Wu   +10 more
wiley   +1 more source

Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis

BMJ Open, 2019
Objectives The objective of this study was to investigate the association between genetic polymorphisms of N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1), glutathione S-transferase (GST) and solute carrier organic anion transporter family ...
Seungwon Yang, Se Jung Hwang, Jung Yun Park, Eun Kyoung Chung, Jangik I Lee   +4 more
doaj   +1 more source