Results 61 to 70 of about 2,707,171 (199)

Role of polymorphic N-acetyl transferase2 (NAT2) and cytochrome P4502E1 (CYP2E1) gene in ATT induced hepatitis

, 2011
Background and Aim: Antituberculosis drugs isoniazid and rifampicin in combination are known to develop drug induced hepatotoxicity (DIH). A higher risk of DIH during antituberculosis treatment (ATT) has been reported in Indian subcontinent compared to ...
Medhi, Subhash, Bose, Purabi Deka, Das, Bhudev Chandra, Kar, Premashis, Husain, Syed Akhtar, Sarma, Manash Pratim   +5 more
core   +1 more source

Pharmacogenomics in Dentistry: From CYP‐Mediated Drug Response to Precision Prescribing in Oral Healthcare

Oral Diseases, EarlyView.
ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci   +3 more
wiley   +1 more source

Induction of SIRT1 by melatonin improves alcohol‐mediated oxidative liver injury by disrupting the CRBN‐YY1‐CYP2E1 signaling pathway

, 2020
Alcoholic liver disease is the most prevalent chronic liver disease. Melatonin is known to control many vital processes. Here, we explored a novel molecular mechanism by which melatonin-induced SIRT1 signaling protects against alcohol-mediated oxidative ...
Sung‐Eun Lee, Chul‐Seung Park, Dong Jin Joo, Park, Chul-Seung, Yong Deuk Kim, Sung-Eun Lee, Balachandar Nedumaran, Hwang-Ju Jeon, Hong Koh, Robert A. Harris, Hwang‐Ju Jeon, 주동진, 고홍   +12 more
core   +2 more sources

CYP2E1 autoantibodies in liver diseases [PDF]

, 2014
Autoimmune reactions involving cytochrome P4502E1 (CYP2E1) are a feature of idiosyncratic liver injury induced by halogenated hydrocarbons and isoniazid, but are also detectable in about one third of the patients with advanced alcoholic liver disease ...
Rigamonti C, Vidali M, SUTTI, Salvatore, ALBANO, Emanuele   +3 more
core   +2 more sources

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, Volume 46, Issue 12, Page 4396-4408, December 2026.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1368-1378, November 2026.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol

, 2013
Background: The hepatic endocannabinoid system and cytochrome P450 2E1 (CYP2E1), a key enzyme causing alcohol-induced reactive oxygen species (ROS) generation, are major contributors to the pathogenesis of alcoholic liver disease.
S H Koo, J Y L Chiang, S B Park, Yong Hoon Kim, H S Choi, W I Jeong, D K Kim, J Park, J R Kim, Chul Ho Lee, T S Park, M Koh, C H Yun, H H Jang   +13 more
core   +1 more source

Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population

BMC Cancer, 2007
Background The distribution and the potential gene-gene and gene-environment interaction of selected metabolic genetic polymorphisms was investigated in relation to gastric cancer risk in an Italian population. Methods One hundred and seven cases and 254
La Torre Giuseppe, D'Ugo Domenico, La Greca Antonio, Arzani Dario, Rausei Stefano, Gianfagna Francesco, Persiani Roberto, Sayed-Tabatabaei Fakhredin A, Boccia Stefania, van Duijn Cornelia M, Ricciardi Gualtiero   +10 more
doaj   +1 more source

Recombinant ADAMTS13 Ameliorates Liver Injury and Improves Hepatic Microcirculation in a Murine Acute‐on‐Chronic Liver Failure Model

Hepatology Research, Volume 56, Issue 11, Page 1737-1748, November 2026.
ABSTRACT Aim The therapeutic significance of recombinant a disintegrin‐like and metalloprotease with thrombospondin type 1 motif 13 (rADAMTS13) in acute‐on‐chronic liver failure (ACLF) remains unclear. We aimed to investigate the therapeutic effects of rADAMTS13 in a murine model of ACLF‐like liver injury.
Jun‐ichi Hanatani, Norihisa Nishimura, Kosuke Kaji, Masayoshi Takami, Hiroyuki Masuda, Hiroaki Takaya, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Hitoshi Yoshiji   +9 more
wiley   +1 more source

Alcohol‐Associated Pancreatitis Confers Higher Risk of Advanced Liver Disease Than Alcohol Withdrawal Syndrome

Journal of Gastroenterology and Hepatology, Volume 41, Issue 11, Page 3557-3566, November 2026.
ABSTRACT Background and Aim Alcohol‐associated liver disease frequently presents late as decompensated cirrhosis, representing a missed opportunity for intervention. Extrahepatic alcohol‐related presentations requiring acute care, such as alcohol‐associated pancreatitis and alcohol withdrawal syndrome, may identify heavy drinkers at varying risk for ...
Butros Fakhoury, Leandro Sierra, Krishan Patel, Hyundam Gu, Luis Antonio Díaz, Juan Pablo Arab   +5 more
wiley   +1 more source