Results 41 to 50 of about 2,707,171 (199)

Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology

Pharmaceutics, 2021
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and ...
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Łukasz Skalski, Mateusz Kurzawski, Stefan Oswald   +7 more
doaj   +1 more source

The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine

, 2003
The importance of the isoform CYP2E1 of the human cytochrome P-450 superfamily of enzymes for occupational and environmental medicine is derived from its unique substrate spectrum that includes a number of highly important high-production chemicals, such
Thier, R., Roos, P. H., Thier, Ricarda, Bolt, Hermann M., Bolt, H. M., Roos, Peter H.   +5 more
core   +1 more source

The Impact of CYP1A2 and CYP2E1 Genes Polymorphism on Theophylline Response

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016
Theophylline is a medicine with narrow therapeutic index. This implies that a small change in dosage would cause side effects. Theophylline is metabolized by CYP1A2 and CYP2E1. The aim of this review is to know the impact of CYP1A2 and CYP2E1 genes polymorphism on theophylline response.
openaire   +3 more sources

Next-Generation Sequencing and Bioinformatics-Based Protocol for the Full-Length CYP2E1 Gene Polymorphism Analysis

Pharmacogenomics and Personalized Medicine, 2022
Viktorija Igumnova,1,2 Agnija Kivrane,1,2 Anda Viksna,3,4 Inga Norvaisa,4 Renate Ranka1,2 1Molecular Microbiology Group, Latvian Biomedical Research and Study Centre, Riga, Latvia; 2Department of Pharmaceutical Chemistry, Riga Stradins University, Riga ...
Igumnova V, Kivrane A, Viksna A, Norvaisa I, Ranka R   +4 more
doaj  

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Nrf2−/− regulated lung DNA demethylation and CYP2E1 DNA methylation under PM2.5 exposure

Frontiers in Genetics, 2023
Cytochrome P450 (CYP450) can mediate fine particulate matter (PM2.5) exposure leading to lung injury. Nuclear factor E2-related factor 2 (Nrf2) can regulate CYP450 expression; however, the mechanism by which Nrf2−/− (KO) regulates CYP450 expression via ...
Mengjie Wu, Menghui Jiang, Hao Ding, Siying Tang, Daochuan Li, Jingbo Pi, Rong Zhang, Wen Chen, Rui Chen, Yuxin Zheng, Jinmei Piao   +10 more
doaj   +1 more source

Subcellular expression of CYP2E1 in HepG2 cells impacts response to free oleic and palmitic acid

Current Research in Toxicology
Aims: Cytochrome P450 2E1 (CYP2E1) is a mammalian monooxygenase expressed at high levels in the liver that metabolizes low molecular weight pollutants and drugs, as well as endogenous fatty acids and ketones.
Zaria K. Killingsworth, Kelly R. Misare, Abigail S. Ryan, Elizabeth A. Ampolini, Tsultrim T. Mendenhall, Melinda A. Engevik, Jessica H. Hartman   +6 more
doaj   +1 more source

Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats [PDF]

The Ukrainian Biochemical Journal, 2013
Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state ...
S. I. Anisimova, G. V. Donchenko, Yu. M. Parkhomenko, V. M. Kovalenko   +3 more
doaj   +1 more source

Effect of Ethanol Consumption on the Placenta and Liver of Partially IGF-1-Deficient Mice: The Role of Metabolism via CYP2E1 and the Antioxidant Enzyme System

Biology, 2022
Ethanol use during pregnancy is a risk factor for developing adverse outcomes. Its metabolism by cytochrome P450 2E1 (CYP2E1) produces radical oxygen species (ROS), promoting cellular injury and apoptosis.
Irene Martín-Estal, Óscar R. Fajardo-Ramírez, Mario Bermúdez de León, Carolina Zertuche-Mery, Rodolfo Benavides-Guajardo, María Isabel García-Cruz, Julieta Rodríguez De Ita, Inma Castilla-Cortázar, Fabiola Castorena-Torres   +8 more
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source