Results 51 to 60 of about 2,707,171 (199)

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

A comprehensive study of CYP2E1 and its role in carcass characteristics and chemical lamb meat quality in different Indonesian sheep breeds.

PLoS ONE
The role of CYP2E1 in oxidation is essential for its effects on meat quality. This study used 200 Indonesian sheep (Ovis aries) to determine the SNP g allele frequencies. g.
Ratna Sholatia Harahap, Asep Gunawan, Yuni Cahya Endrawati, Huda Shalahudin Darusman, Göran Andersson, Ronny Rachman Noor   +5 more
doaj   +1 more source

Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population

Human Genomics, 2011
Cytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds.
Sameer A, Nissar Saniya, Qadri Qurteeba, Alam Shafia, Baba Shahid, Siddiqi Mushtaq A   +5 more
doaj   +1 more source

Systematic functional characterization of cytochrome P450 2E1 promoter variants in the Chinese Han population. [PDF]

PLoS ONE, 2012
CYP2E1 promoter polymorphisms can lead to significant interindividual differences in expression of CYP2E1. Using a database of CYP2E1 gene polymorphisms established in 2010, our study aimed to functionally characterize the single nucleotide polymorphisms
Xunyi Huang, Lili Chen, Wenlong Song, Ling Chen, Jiamin Niu, Xia Han, Guoyin Feng, Lin He, Shengying Qin   +8 more
doaj   +1 more source

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

β-Carotene Increases Activity of Cytochrome P450 2E1 during Ethanol Consumption

Antioxidants, 2022
One of the key routes through which ethanol induces oxidative stress appears to be the activation of cytochrome P450 2E1 at different levels of ethanol intake.
Cristian Sandoval, Luciana Mella, Karina Godoy, Khosrow Adeli, Jorge Farías   +4 more
doaj   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Effects of Real-Ambient PM2.5 Exposure on Lung Damage Modulated by Nrf2−/−

Frontiers in Pharmacology, 2021
Previous studies have shown that long-term exposure to fine particulate matter (PM2.5) increases the morbidity and mortality of pulmonary diseases such as asthma, chronic obstructive pulmonary disease and pulmonary emphysema.
Hao Ding, Menghui Jiang, Daochuan Li, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Jingbo Pi, Rui Chen, Lianhua Cui, Yuxin Zheng, Jinmei Piao   +11 more
doaj   +1 more source

mRNA and miRNA Sequencing Identifies Increased Oxidative Stress Pathways in a Mouse Model of Ethanol Exacerbation of Colitis [PDF]

Alcohol Clin Exp Res (Hoboken)
This study suggests that altered miRNA and mRNA expression related to reactive oxygen species (ROS/RNS)–producing proteins NOS2, CYBB, and NCF1 potentially contribute to alcohol exacerbation of disease pathology in patients with ulcerative colitis. Created in BioRender. Tschann, M.
Tschann M, Murray M, Cannon A, Kuprys P, Dine K, Eberhardt J, Ding X, Xi N, Pekow J, Choudhry M.   +9 more
europepmc   +2 more sources

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source