Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. [PDF]
PLoS ONE, 2014 With the use of iTRAQ technique, a multifactorial comparative proteomic study can be performed. In this study, to obtain an overview of ethanol, CYP2E1 and gender effects on liver injury and gain more insight into the underlying molecular mechanism ...
Yuan Wang +4 more
doaj +1 more source
Investigation of CYP2E1 and Caspase-3 Gene Expressions in COVID-19 patients
Gene Reports, 2022 COVID-19 pandemic spread around the world like an infectious disease that presents waved effects on patients. Some patients needed ICU and respiratory support. Some patients only had flu-like symptoms. Cytokine storm and elevated ROS were serious problems for treatment.
Hallcl, Zekai +4 more
openaire +4 more sources
Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese [PDF]
PeerJ, 2020 Backgrounds Cytochrome P450 (P450) 2E1 is one of the primary enzymes responsible for the metabolism of xenobiotics, such as drugs and environmental carcinogens.
Ting Wang +11 more
doaj +2 more sources
Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex
Life, 2022 Background: Epigenetic factors including DNA methylation contribute to specific patterns of gene expression. Gene–environment interactions can change the methylation status in the brain, and accumulation of these epigenetic changes over a lifespan may be
Oliver Kaut +6 more
doaj +1 more source
CYP2E1 and GSTM1 gene polymorphisms, environmental factors, and the susceptibility to lung cancer [PDF]
Journal of Clinical Laboratory Analysis, 2018 ObjectiveTo investigate the relationships between the CYP2E1 RsaI polymorphism, GSTM1 polymorphism, and the susceptibility to lung cancer, along with the interactions between environmental factors and these genes.MethodsA case‐control study was carried out to explore the independent effect of gene polymorphisms on risk of lung cancer, and the combined ...
Qingfang He +8 more
openaire +2 more sources
Fisetin Attenuates Paracetamol-Induced Hepatotoxicity by Regulating CYP2E1 Enzyme [PDF]
Anais da Academia Brasileira de Ciências, 2023 Paracetamol is one of the drugs that cause hepatic damage. Fisetin has wide pharmacological effects such as anticancer, antiinflammatory and antioxidant. We aimed to evaluate the possible protective effect of fisetin on paracetamol-induced hepatotoxicity.
RUSTEM A. UGAN +4 more
doaj +1 more source
Functional PstI/RsaI polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: Cytochrome P450 2E1 (CYP2E1), an ethanol-inducible enzyme, has been shown to metabolically activate various carcinogens, which is critical for the development and progression of cancers. It has demonstrated that CYP2E1 polymorphisms alter the
Jin Feng +7 more
doaj +1 more source
CYP2E1-DEPENDENT VARIATIONS IN HEPATOCYTES DAMAGE DURING TREATMENT OF TUBERCULOSIS
Медична наука України, 2020 Relevance. Investigation of polymorphism in a locus of CYP2E1 as the prognostic factor of drug-induced hepatotoxicity at anti-TB therapy is significant due to the influence of CYP2E1 on drug metabolism. The objective of the investigation is to analyze
L.V. Natrus +4 more
doaj +1 more source
Identification of 2-Piperidone as a Biomarker of CYP2E1 Activity Through Metabolomic Phenotyping [PDF]
, 2013 Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the metabolic activation of many low molecular weight toxicants and also an important contributor to oxidative stress.
Cheng, Jie +8 more
core +3 more sources
Primers used for making CYP2E1 promoter luciferase reporter gene constructs.
, 2014 Primers used for making CYP2E1 promoter luciferase reporter gene constructs.
Xiaodong Wang (66801) +6 more
core +1 more source