Results 21 to 30 of about 2,707,171 (199)

Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS [PDF]

Cell Communication and Signaling, 2020
Background Cells taken from mouse embryos before sex differentiation respond to insults according to their chromosomal sex, a difference traceable to differential methylation.
Carlos G. Penaloza, Mayra Cruz, Gabrielle Germain, Sidra Jabeen, Mohammad Javdan, Richard A. Lockshin, Zahra Zakeri   +6 more
doaj   +2 more sources

Cytochrome P2E1 (CYP2E1) Gene Polymorphism as a Potential Prognostic Biomarker in Colorectal Cancer. [PDF]

Asian Pac J Cancer Prev, 2023
Colon cancer is the most common type of gastrointestinal cancer. Genetic factors have been shown to have a role in the development of colorectal cancers. The aim of this study was to assess the expression of Cytochrome P2E1 (CYP2E1) gene polymorphism as a potential prognostic biomarker in the diagnosis, treatment, and prognosis evaluation of patients ...
Moghadas A, Karbalaie Niya MH, Zamani F, Moazzami M, Farhang F, Ajdarkosh H, Khoonsari M, Faraji A, Panahi M, Emtiazi N, Safarnezhad Tameshkel F, Nikkhah M.   +11 more
europepmc   +3 more sources

Expression of CYP2E1 gene in paint workers occupationally exposed to organic solvents

VNU Journal of Science: Natural Sciences and Technology, 2019
Benzene (B), toluene (T), ethylbenzene (E) and xylene (X) are used commonly in paint industry, so workers who are a high risk of exposure to organic solvent (VOCs). CYP2E1 gene encodes CYP2E1 which plays an important role in the metabolism and bio-activation of volatile organic compounds. When workers expose to VOCs, their body will have a mechanism to
Nguyen Quang Huy, Bui Phuong Thuan, Nguyen Phu Hung, Do Thi Cam Nhung, Nguyen Thi Hien   +4 more
openaire   +3 more sources

ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. [PDF]

Genes (Basel), 2023
Increasing alcohol consumption by women of childbearing age contributes to more frequent cases of fetal alcohol spectrum disorder. The cause of the syndrome is fetal alcohol exposure, particularly what is referred to as high prenatal alcohol exposure.
Kukowka A, Brzuchalski B, Kurzawski M, Malinowski D, Białecka MA.   +4 more
europepmc   +3 more sources

Association of CYP2E1 gene polymorphisms with bladder cancer risk: A systematic review and meta-analysis. [PDF]

Medicine (Baltimore), 2018
Human cytochrome P450 (CYP) is an enzyme responsible for the metabolic activation of many carcinogens, including nitrosamines. CYP2E1 represents a major CYP isoform and is expressed in the human urothelial cells. Recent studies have investigated the association of CYP2E1 gene polymorphisms with bladder cancer risk but have shown contradictory results ...
Yin X, Xiong W, Wang Y, Tang W, Xi W, Qian S, Guo Y.   +6 more
europepmc   +3 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Transcriptional Control of the Rat Hepatic CYP2E1 Gene [PDF]

Molecular and Cellular Biology, 1990
The rat hepatic CYP2E1 gene becomes transcriptionally activated within 1 day after birth. This activation can be mimicked by using the 5' end of the gene in a cell-free nuclear extract prepared from hepatocytes taken from rats at different developmental stages.
T, Ueno, F J, Gonzalez
openaire   +2 more sources

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
Ma, Jinfeng, Xuemei Yao, Mingqin Cao, Merle Corinne, Xia Zhu, Liu Wei, Weidong Wu, Yongguang Li, Jiayi Gu, Ma Jinfeng, Qian Wang, Milligan Paul, Zhu, Xia, Ying Mao, Liu, Wei, Ma Long, Jinfeng Ma, Xiang, Yang, Cao, Mingqin, Ma, Long, Merle, Corinne, Long Ma, Yang Lei, Xiang Yang, Yao Xuemei, Wubuli, Atikaimu, Wu, Weidong, Xin Xiumei, Li, Yongguang, Yang Xiang, Paul Milligan, Xiumei Xin, Lei Yang, Corinne Merle, Zhu Xia, Li Yongguang, Mao Ying, Milligan, Paul, Mao, Ying, Gu, Jiayi, Atikaimu Wubuli, Gu Jiayi, Yao, Xuemei, Wu Weidong, Wang Qian, Yang, Lei, Xin, Xiumei, Wang, Qian, Cao Mingqin, Wubuli Atikaimu, Wei Liu   +50 more
core   +1 more source

Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells [PDF]

Experimental Biology and Medicine, 2010
The incidence of hepatocellular carcinoma is rising due to alcohol drinking, hepatitis C viral infection and metabolic syndrome. Differential expression of CYP2E1 may play a pleiotropic role in the multistep process of liver carcinogenesis. Considerable attention has focused on the antitumor effect of trichostatin A (TSA) as well as CYP2E1 expression ...
Hui, Yang, Yuqiang, Nie, Yuyuan, Li, Yu-Jui Yvonne, Wan   +3 more
openaire   +2 more sources

Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort

Clinical Epigenetics, 2023
Background Acetaminophen is a commonly used medication by pregnant women and is known to cross the placenta. However, little is known about the biological mechanisms that regulate acetaminophen in the developing offspring.
Yijun Li, Xiumei Hong, Liming Liang, Xiaobin Wang, Christine Ladd-Acosta   +4 more
doaj   +1 more source