Results 81 to 90 of about 2,707,171 (199)

Comparative Evaluation of Ethanolic Extracts Obtained From the Seeds of White and Black Açai Exhibit Antioxidant and Cytoprotective Activity In Vitro

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Açai seed extracts (black/white) showed antioxidant activity (black ∼30% stronger), no cytotoxicity or genotoxicity, and transient cytoprotection in normal and cancer cell lines. Black extract (200 µg/mL) inhibited colony formation without reducing cisplatin efficacy. Phenolic‐rich seed waste warrants further therapeutic study. ABSTRACT The açai fruit (
Luana França Calandrini de Azevedo, Estanislaw Tairowite Prestes Correa, Hemilly Casanova Gonçalves Soeiro, Oscar Vinícius Moraes dos Santos, Gustavo Henrique da Silva Lopes, Karina Motta Melo, Vinicius Silva de Carvalho, Andryo Orfi de Almada Vilhena, Jorge das Dores Rissino, Karen Albuquerque Dias da Costa, Alberdan da Silva Santos, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka   +12 more
wiley   +1 more source

Harnessing Terminalia arjuna in Next Generation Phytomedicine: Cutting Edge Nutraceutical Trends Shaping Food and Health

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee, Fahika Nazeerulla, Manash Kumar Paul, Sujit Kumar Bhutia, Deblina Basu, Subhadip Mukhopadhyay   +5 more
wiley   +1 more source

Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013
We have shown that alcohol increases Caco-2 intestinal epithelial cell monolayer permeability in vitro by inducing the expression of redox-sensitive circadian clock proteins CLOCK and PER2 and that these proteins are necessary for alcohol-induced hyperpermeability.
Christopher B, Forsyth, Robin M, Voigt, Maliha, Shaikh, Yueming, Tang, Arthur I, Cederbaum, Fred W, Turek, Ali, Keshavarzian   +6 more
openaire   +3 more sources

Ya‐Jie‐Sha‐Ba Decoction Regulates Arachidonic Acid Metabolism to Treat Alcohol‐Associated Liver Disease by Activating PPARα–CYP4A14 Axis: Insights From Multi‐Omics Analysis and Experimental Validations

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Ya‐Jie‐Sha‐Ba decoction (YJSB), a traditional Dai medicinal formulation, has been widely used by the Dai ethnic group and has shown efficacy in alleviating alcohol‐associated liver disease (ALD). However, the molecular mechanism of YJSB in the management of ALD remains unclear.
Dehong Ma, Xia Chen, Huixian Dao, Hongyu Deng, Yingcheng Guo, Hui Yang, Yuanyuan Chen, Congmei Zhang, Yuan Long, Weibo Wen, Yinghong Zhao, Huantian Cui   +11 more
wiley   +1 more source

Functional PstI/RsaI Polymorphisms in the CYP2E1 Gene among South Indian Populations

Asian Pacific Journal of Cancer Prevention, 2013
Human cytochrome P4502E1 (CYP2E1) is a well-conserved xenobiotic-metabolizing enzyme expressed in liver, kidney, nasal mucosa, brain, lung, and other tissues. CYP2E1 is inducible by ethanol, acetone, and other low-molecular weight substrates and may mediate development of chemically-mediated cancers.
Saikrishna, Lakkakula, Rajasekhar, Maram, Arasambattu Kannan, Munirajan, Ram Mohan, Pathapati, Subrahmanyam Bhattaram, Visveswara, Bhaskar Vks, Lakkakula   +5 more
openaire   +3 more sources

CYP2E1 and risk of chemically mediated cancers

, 2010
Importance of the field: Among various human CYPs, CYP2E1 is of particular interest because of its involvement in the metabolic activation of many low molecular mass procarcinogens.
Trafalis, D.T., Panteli, E.S., Tsigris, C., Karamanakos, P.N., Grivas, A.   +4 more
core  

Novel CYP2E1 haplotype identified in a South African cohort

South African Journal of Science, 2014
Alcohol abuse accounts for approximately 2.5 million deaths annually and is the third highest risk factor for disease and disability. Alcohol is metabolised by polymorphic enzymes and the status of an individual with respect to alcohol metabolising ...
Laura J. Heathfield, Shareefa Dalvie, Kusha Kalideen, Collet Dandara   +3 more
doaj   +1 more source

Association of CYP2E1 gene polymorphism with predisposition to cancer development.

Experimental oncology, 2006
We summarize research results on association of cytochrome P450 2E1 (CYP2E1) genetic polymorphisms with the development of ecologically determined cancers. Cytochrome P450 monooxygenase enzyme system is involved in metabolic activation of procarcinogens, which is an important stage during normal cell transformation into a malignant one.
I M, Danko, N A, Chaschin
openaire   +1 more source

Role ofCYP2E1gene polymorphisms association with hepatitis risk in Northeast India

World Journal of Gastroenterology, 2010
To investigate hepatitis virus, genetic and environmental factors, and their interactions in predisposing patients to liver diseases in Northeast India.A total of 104 jaundice patients and 124 community controls were included. Serological analysis was performed by routine enzyme-linked immunosorbent assay, and nucleic acid testing for hepatitis viruses
Manab, Deka, Moumita, Bose, Bharati, Baruah, Purabi Deka, Bose, Subhash, Medhi, Sujoy, Bose, Anjan, Saikia, Premashish, Kar   +7 more
openaire   +2 more sources

Phytic acid attenuates acetaminophen-induced hepatotoxicity via modulating iron-mediated oxidative stress and SIRT-1 expression in mice

Frontiers in Pharmacology
Introduction: Administration of high doses of acetaminophen (APAP) results in liver injury. Oxidative stress and iron overload play roles in the pathogenesis of APAP-induced hepatotoxicity.
Hend M. Hassan, Hend M. Hassan, Nehal H. M. Abdel-Halim, Ibrahim El-Shenbaby, Manar A. Helmy, Maha O. Hammad, Ola A. Habotta, Eman M. El Nashar, Mansour A. Alghamdi, Mansour A. Alghamdi, Rashid A. Aldahhan, Khulood M. Al-Khater, Basmah Almohaywi, Eman A. E. Farrag   +13 more
doaj   +1 more source