Results 101 to 110 of about 2,707,171 (199)

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Cell Reports, 2013
Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied.
Xiaofen Li, Shouting Liu, Hongbiao Huang, Ningning Liu, Chong Zhao, Siyan Liao, Changshan Yang, Yurong Liu, Canguo Zhao, Shujue Li, Xiaoyu Lu, Chunjiao Liu, Lixia Guan, Kai Zhao, Xiaoqing Shi, Wenbin Song, Ping Zhou, Xiaoxian Dong, Haiping Guo, Guanmei Wen, Change Zhang, Lili Jiang, Ningfang Ma, Bing Li, Shunqing Wang, Huo Tan, Xuejun Wang, Q. Ping Dou, Jinbao Liu   +28 more
doaj   +1 more source

Ethanol Induction of CYP2A5: Role of CYP2E1-ROS-Nrf2 Pathway

, 2012
Chronic ethanol consumption was previously shown to induce CYP2A5 in mice, and this induction of CYP2A5 by ethanol was CYP2E1 dependent. In this study, the mechanisms of CYP2E1-dependent ethanol induction of CYP2A5 were investigated.
Cederbaum, Arthur I., Zhang, Xu Hannah, Lu, Yongke   +2 more
core   +1 more source

Variable Number of Tandem Repeats (VNTR) gene polymorphism of CYP2E1 in patients with pancreatic adenocarcinoma

, 2010
Context: The genetic polymorphism is considered a major source of variability, influencing the levels of gene expression. Cytochrome P450 2E1 (CYP2E1) is a mixed-function oxidase involved in the metabolism of the many endogenous and exogenous ...
Marasà, L, CARADONNA, Fabio, CATANZARO, Irene, GIANNITRAPANI, Lydia, Naselli, F, GIACALONE, Antonio Mario, MONTALTO, Giuseppe, Marasà, S, Gangeri, M   +8 more
core  

Genetic Polymorphisms of Genes Coding to Alcohol-Metabolizing Enzymes in Western Mexicans: Association of CYP2E1*c2/CYP2E1*5B Allele with Cirrhosis and Liver Function

, 2012
Background: Alcoholic cirrhosis constitutes a major public health problem in the world where ADH1B, ALDH2, and CYP2E1 polymorphisms could be playing an important role.
Garcia-Banuelos, J., Bastidas-Ramirez, B.E., Gordillo-Bastidas, E., Gordillo-Bastidas, D., Gurrola-Diaz, C.M., Sanchez-Enriquez, S., Ruiz-Madrigal, B., Munoz-Valle, J.F., Panduro-Cerda, Arturo   +8 more
core   +1 more source

CYP2E1 VNTR polymorphisms and hepatocarcinoma: a gender-specific correlation

, 2010
Cytochrome P450 (CYP2E1) is often associate to susceptibility to alcohol-related diseases and various cancers, because of its role in the metabolism of multiple environmental xenobiotics.
Marasà, L, CARADONNA, Fabio, CATANZARO, Irene, SCIANDRELLO, Giulia, GIACALONE, Antonio Mario, MONTALTO, Giuseppe, SAVERINI, Marghereth, NASELLI, Flores   +7 more
core  

The Effects of Cyp2e1 on Hepatic Gene Expression in 129/Sv-Cyp2e1^tm1Gonz/J and 129S1/SvImJ Mice Exposed to Hydrazine

, 2007
Class of 2007 AbstractObjectives: To characterize the difference in hepatic gene expression between Cyp2e1 +/+ and Cyp2e1 -/- mice after exposure to hydrazine in order to elucidate the functional pathway(s) for hydrazine-induced steatosis.
Lindgren, Kristjon, Seng, Dana
core   +2 more sources

Relationship between CYP2E1 Gene Polymorphism and Anti-tuberculosis Drug-induced Liver Injury

, 2018
 Objective: To investigate the relationship between cytochrome P450 E1 (CYP2E1) gene polymorphisms and susceptibility to anti-tuberculosis drug-induced liver damage (ATDLI) in tuberculosis patients in the Chinese Han nationality. Methods: A retrospective
Xi, Yun, Huang, Fanhua, Zhu, Donglin, Xiao, Gang, Xu, Changzhi, Dong, Jieming   +5 more
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Roles of CYP1A1 and CYP2E1 Gene Polymorphisms in Oral Submucous Fibrosis.

Asian Pacific journal of cancer prevention : APJCP, 2017
Oral submucous fibrosis (OSF) is a precancerous condition with a 4 to13% malignant transformation rate. Related to the habit of areca nut chewing it is mainly prevalent in Southeast Asian countries where the habit of betel quid chewing is frequently practised. On chewing, alkaloids and polyphenols are released which undergo nitrosation and give rise to
Punyo, Yaming, Aadithya Basavaraj, Urs, Alpana, Saxena, Mariyam, Zuberi   +3 more
openaire   +1 more source

Potent mutagenicity of some non-planar tri- and tetrachlorinated biphenyls in mammalian cells, human CYP2E1 being a major activating enzyme.

, 2017
Polychlorinated biphenyls (PCBs) have been classified as human carcinogens. Mutagenicity of lower chlorinated biphenyls as well as activation of transcription factors by some other congeners may contribute to the carcinogenicity of PCBs.
Liu, Yungang, Hu, Keqi, Jia, Hansi, Jin, Guifang, Glatt, Hansruedi, Jiang, Hao   +5 more
core   +1 more source

Association of the blood biochemical index with CYP2E1 5\ue2flanking region Rsa I/Pst I gene polymorphism and alcohol consumption habit in Southern Taiwan aborigines

, 2005
The microsomal ethanol oxidizing system (MEOS) is involved in metabolism of alcohol in the liver, the major component of MEOS is cytochrome P4502E1 (CYP2E1). CYP2E1 gene polymorphisms that alter its functions may be associated with alcohol susceptibility
Kuo, Chia-ling
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