Results 251 to 258 of about 75,915 (258)

Homology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions

Xenobiotica, 2004
1. The results of homology modelling of cytochrome P4503A4 (CYP3A4), which is a human enzyme of major importance for the Phase 1 metabolism of drug substrates, from the CYP2C5 crystal structure is reported. 2. The overall homology between the two protein sequences was generally good (46%) with 24% of amino acid residues being identical and a 22 ...
D F V, Lewis, B G, Lake, M, Dickins, P S, Goldfarb   +3 more
openaire   +2 more sources

CYP3A4-mediated Pharmacokinetic Interactions in Cancer Therapy

Current Drug Metabolism, 2015
Cytochromes P450 enzymes, especially CYP3A4, are responsible for metabolizing a broad range of anticancer drugs. Combination therapy is common in patients with cancer, which may cause potential drug drug interactions (DDIs) leading to increased risk of side-effects/toxicity or decreased effectiveness.
Tian, D, Hu, Z
openaire   +4 more sources

CYP3A4Intron 6 C>T SNP (CYP3A4*22) Encodes Lower CYP3A4 Activity in Cancer Patients, as Measured with Probes Midazolam and Erythromycin

Pharmacogenomics, 2013
The CYP3A4*22 allele was recently reported to be associated with reduced CYP3A4 activity. We investigated the impact of this allele on the metabolism of the CYP3A-phenotyping probes, midazolam (MDZ) and erythromycin.Genomic DNA from 108 cancer patients receiving intravenous MDZ and 45 undergoing the erythromycin breath test was analyzed for CYP3A4*22 ...
Elens, Laure, Nieuweboer, Annemieke, Clarke, SJ, Charles, KA, Graan, Anne-joy, Haufroid, V, Mathijssen, RHJ, van Schaik, Ron   +7 more
openaire   +3 more sources

CYP3A4 and CYP3A5 Genotyping Recommendations

The Journal of Molecular Diagnostics, 2023
Victoria M. Pratt, Larisa H. Cavallari, Makenzie L. Fulmer, Andrea Gaedigk, Houda Hachad, Yuan Ji, Lisa V. Kalman, Reynold C. Ly, Ann M. Moyer, Stuart A. Scott, Ron H.N. van Schaik, Michelle Whirl-Carrillo, Karen E. Weck   +12 more
openaire   +1 more source

Optimalizace přípravy rekombinantního CYP3A4

Cytochrome P450 3A4 is the most abundant cytochrome in the human body. It plays a key role in the metabolism of xenobiotics, being involved in the metabolism of 30 to 50 % of all clinically used drugs. It also participates in the metabolism of endogenous substrates and is involved in certain cancerous diseases.
openaire   +1 more source

CYP3A4 and the erythromycin breath test

Clinical Pharmacology & Therapeutics, 1998
openaire   +2 more sources

CYP3A4

openaire   +1 more source

CYP3A4 inhibitors contraindicated with ergotamine

Reactions Weekly, 2003
openaire   +1 more source