Results 251 to 260 of about 61,480 (319)

A mismatch in enzyme-redox partnerships underlies divergent cytochrome P450 activities between human hepatocytes and microsomes. [PDF]

Commun Biol
Bapiro TE, Martin S, Blacker TS, Wilkinson SD, Orton AL, Hariparsad N, Jones RDO, Duchen MR, Harlfinger S.   +8 more
europepmc   +1 more source

Ammonium Hydroxide Enhancement of Dietary Protein in High-Fat Diets Modulates Liver Metabolism Signaling in a Sex- and Age-Dependent Manner in C3H/HeJ Mice. [PDF]

Int J Mol Sci
Barr BR, Subramaniyan I, Li L, Levitt DE, Gollahon LS.   +4 more
europepmc   +1 more source

Relative Contributions of Cytochrome CYP3A4 Versus CYP3A5 for CYP3A-Cleared Drugs Assessed In Vitro Using a CYP3A4-Selective Inactivator (CYP3cide)

Drug Metabolism And Disposition, 2014
E. Tseng, R. Walsky, Ricardo A. Luzietti, Jennifer J. Harris, R. Kosa, T. Goosen, Michael A. Zientek, R. Obach   +7 more
semanticscholar   +1 more source

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Pharmacokinetics and Drug Interactions. [PDF]

Pharmaceutics
Choi MK, Song IS.
europepmc   +1 more source

Impact of CYP3A4*1B and CYP3A5*3 polymorphisms on the pharmacokinetics of cyclosporine and sirolimus in renal transplant recipients

, 2012
Leszek Pączek
openalex   +1 more source

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation. [PDF]

Basic Clin Pharmacol Toxicol
Wang F, Gu X, Hong H, Xia Q, Zhang Y, Song Y, Li B, Fan P.   +7 more
europepmc   +1 more source

Mechanism-Based Inhibition of CYP3A4 by Constituents of Zingiber aromaticum

, 2005
Tepy Usia, Tadashi Watabe, Shigetoshi Kadota, Yasuhiro Tezuka   +3 more
openalex   +2 more sources

Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor. [PDF]

Front Immunol
Lin T, Chen Y, Liu L, Wu T, Qian Y, Jin B.   +5 more
europepmc   +1 more source