Results 241 to 250 of about 56,913 (295)

Liquid Compared to Solid Oral Formulations of the Thyroid Hormone Receptor Agonist Elunetirom Under Fasted and Fed Conditions in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Elunetirom (ABX‐002) is a brain‐targeted, oral prodrug being developed for the adjunctive treatment of major depressive disorder and bipolar depression. The active moiety, LL‐340001, is a thyroid hormone receptor agonist with modest selectivity for beta over alpha thyroid hormone receptors. Upon entering the brain, the intended site of action,
Jason R. Harris, Aernout D. van Haarst, Jill Baccei, Bridgette Franey, Jason Everett, Kory George, Sabina Paglialunga, Kenneth Webster, Michelle Hillstrand, Chris Banfield, Thomas S. Scanlan, Gudarz Davar   +11 more
wiley   +1 more source

Engineering human Gut-on-a-Chip culturomics for predictive pharmacomicrobiomics of first-pass metabolism. [PDF]

NPJ Biomed Innov
Nagao I, Kim HJ.
europepmc   +1 more source

Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review. [PDF]

Pharmaceuticals (Basel)
Dumitru CN, Marcu T, Dumitru AO, Tudor SS, Ferțu ID, Elisei AM, Goroftei L.   +6 more
europepmc   +1 more source

Integrated Chemical Profiling and Toxicological Assessment of Total Polyphenols from <i>Cydonia oblonga</i> Mill. Reveals Potential Safety Concerns Under High-Dose Exposure. [PDF]

Foods
Aikebaier A, Baishan A, Abudurousuli K, Dilimulati D, Paerhati Y, Maitikasimu K, Wusiman Y, Yusufujiang N, Qiu X, Zhou W.   +9 more
europepmc   +1 more source

Multi-Endpoint Prediction of Bioactivity and ADMET Properties Coupled with Multi-Objective Optimization in Molecular Descriptor Space for Candidate ERα Antagonists. [PDF]

Pharmaceuticals (Basel)
Cui Y, Qiao Y, Ren H, Qiu L.
europepmc   +1 more source

Case Report: When access is limited: using CYP3A4 inhibition to maintain clinical benefit from elexacaftor/tezacaftor/ivacaftor. [PDF]

Front Pharmacol
Hiscock K, Wood M, Johnson E, Smith D, Evans IES.   +4 more
europepmc   +1 more source

Bridging the Pregnancy Knowledge Gap: A Real-World Analysis of Medication Use and Drug-Drug Interaction Risk in Crohn's Disease and Multiple Sclerosis. [PDF]

Clin Transl Sci
Williams J, Sane R, Joshi A, Cheung KWK, Vora B.   +4 more
europepmc   +1 more source