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CYP3A4*1G regulates CYP3A4 intron 10 enhancer and promoter activity in an allelicdependent manner
Int. Journal of Clinical Pharmacology and Therapeutics, 2015CYP3A4*1G (G > A) in human CYP3A4 intron 10 is associated with therapeutic effects of CYP3A4-metabolized drugs. The aim of this study was to predict its function in the regulation of CYP3A4 expression.Functional analysis of the CYP3A4*1G allele was performed using bioinformatic methods and enhancer or promoter reporter assays in HepG2 cells ...
Weihong, Yang +8 more
openaire +2 more sources
Genetic epidemiology of induced CYP3A4 activity
Pharmacogenetics and Genomics, 2011The cytochrome P450 3A4 (CYP3A4) enzyme is implicated in the metabolism of more than 50% of all prescribed medications and its activity - including induced or inhibited activity - is deemed to be a crucial determinant of interindividual variability in drug disposition, poor therapeutic efficacy, and adverse response to medication.We used the classical ...
Rahmioglu, Nilufer +10 more
openaire +4 more sources
Functional assessment of the effects of CYP3A4 variants on acalabrutinib metabolism in vitro
Chemico-Biological Interactions, 2021Hu Guoxin, Jianchang Qian, Zhize Ye
exaly
Effects of drug-drug interactions and CYP3A4 variants on alectinib metabolism
Archives of Toxicology, 2023Hu Guoxin, Ren-Ai Xu, Jian-Ping Cai
exaly
CYP3A4*22: Promising Newly IdentifiedCYP3A4Variant Allele for Personalizing Pharmacotherapy
Pharmacogenomics, 2013Teun Van Gelder +2 more
exaly
CYP3A4 and the erythromycin breath test
Clinical Pharmacology & Therapeutics, 1998openaire +2 more sources
CYP3A4 Polymorphisms--Potential Risk Factors for Breast and Prostate Cancer: A HuGE Review
American Journal of Epidemiology, 2004Ainsley Weston
exaly