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CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation? [PDF]
Frontiers in Genetics, 2021 Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically prescribed drugs.
Mathijssen Ron +2 more
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Effect of Mibefradil on CYP3A4 In Vivo
The Journal of Clinical Pharmacology, 2003Mibefradil, a calcium channel blocker, was removed from the market because of adverse drug interactions with coadministered CYP3A4 substrates. This study examined the effect of mibefradil on the activity of hepatic and intestinal CYP3A4 in vivo, employing the erythromycin breath test (EBT) and oral midazolam pharmacokinetics.
Maria L, Veronese +5 more
openaire +2 more sources
Pioglitazone: Effect on CYP3A4 Activity
The Journal of Clinical Pharmacology, 2002Clinical studies demonstrate CYP3A4 enzyme induction with troglitazone, a thiazolidinedione derivative structurally related to pioglitazone. The objective of this prospective, open‐label study conducted in healthy volunteers was to evaluate the influence of multiple‐dose pioglitazone therapy on the urinary excretion ratio of 6‐β‐hydroxycortisol to ...
Sandra N, Nowak +4 more
openaire +2 more sources
Functional Gene Variants of CYP3A4
Clinical Pharmacology & Therapeutics, 2014Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other foreign compound-metabolizing enzyme in humans. Recently, increasing evidence has been found showing that variants in the CYP3A4 gene have functional significance and--in rare cases--lead to loss of activity, implying tremendous consequences for ...
A N, Werk, I, Cascorbi
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The Role of CYP3A4 in Amiodarone-Associated Toxicity on HepG2 Cells
Biochemical Pharmacology, 2011 Amiodarone is a class III antiarrhythmic drug with potentially life-threatening hepatotoxicity. Recent in vitro investigations suggested that the mono-N-desethyl (MDEA) and di-N-desethyl (DDEA) metabolites may cause amiodarone's hepatotoxicity.
Stephan Krähenbühl +2 more
exaly +2 more sources
2015
This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 3A4.
Jennifer DeCou +2 more
openaire +1 more source
This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 3A4.
Jennifer DeCou +2 more
openaire +1 more source