Results 161 to 170 of about 2,697 (198)
Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases [PDF]
Neurotherapeutics, 2019 Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. This review describes CYP46A1 in the context of cholesterol homeostasis in the brain and summarizes available experimental data on CYP46A1 association with different neurologic ...
Alexey M Petrov, Irina A Pikuleva
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CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease [PDF]
Brain, 2016 Huntington's disease is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of striatal neurons. Altered brain cholesterol homeostasis has been implicated in Huntington's disease, with increased accumulation of cholesterol in striatal neurons yet reduced levels of ...
Sandro Alves +2 more
exaly +5 more sources
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CYP46A1 and the APOEε4 Allele Polymorphisms Correlate with the Risk of Alzheimer’s Disease
Molecular Neurobiology, 2018Polymorphisms of the cholesterol-24S-hydroxylase (CYP46A1) and apolipoprotein E (APOE) genes are risk factors for Alzheimer's disease (AD). Plasma level of 24S-hydroxcholesterol (24-OHC), the metabolite of cholesterol, is thought to correlate with AD.
Fan Zeng, Yu-Hui Liu, yanjiang wang
exaly +3 more sources
European Journal of Pharmacology, 2023
Cholesterol is a key component of the cell membrane that impacts the permeability, fluidity, and functions of membrane-bound proteins. It also participates in synaptogenesis, synaptic function, axonal growth, dendrite outgrowth, and microtubule stability. Cholesterol biosynthesis and metabolism are in balance in the brain.
Ali Roohbakhsh
exaly +3 more sources
Cholesterol is a key component of the cell membrane that impacts the permeability, fluidity, and functions of membrane-bound proteins. It also participates in synaptogenesis, synaptic function, axonal growth, dendrite outgrowth, and microtubule stability. Cholesterol biosynthesis and metabolism are in balance in the brain.
Ali Roohbakhsh
exaly +3 more sources
Metabolism of oral turinabol by the human brain cholesterol 24-hydroxylase CYP46A1
The Journal of Steroid Biochemistry and Molecular Biology, 2021The human microsomal cytochrome P450 enzyme CYP46A1 plays a crucial role in cholesterol elimination from the brain. It performs a 24-hydroxylation of cholesterol and is of outstanding significance for memory and cognition. This study demonstrates the catalytic activity of human CYP46A1 towards an anabolic androgenic steroid, oral turinabol ...
Natalia Putkaradze +5 more
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Cholesterol-24S-hydroxylase (CYP46A1) Is Specifically Expressed in Neurons of the Neural Retina
Current Eye Research, 2007Increasing biological findings argue for the importance of cholesterol-24S-hydroxylase (CYP46A1) in cholesterol homeostasis in cerebral structures. Based on the similarity between the brain and the neural retina, the aim of the current study was to evaluate the expression of CYP46A1 in the mammalian retina.
Brétillon, Lionel +9 more
openaire +4 more sources
Neuroscience Letters, 2016
Polymorphisms in the CYP46A1 rs4900442 have been controversially associated with increased risk of developing Alzheimer's disease (AD). Therefore, a meta-analysis was performed to assess the possible association between CYP46A1 gene rs4900442 polymorphism and AD. A comprehensive search was conducted to identify all case-control or cohort design studies
Kai Liu, Hong Jiang
exaly +3 more sources
Polymorphisms in the CYP46A1 rs4900442 have been controversially associated with increased risk of developing Alzheimer's disease (AD). Therefore, a meta-analysis was performed to assess the possible association between CYP46A1 gene rs4900442 polymorphism and AD. A comprehensive search was conducted to identify all case-control or cohort design studies
Kai Liu, Hong Jiang
exaly +3 more sources
$CYP46A1$ Functional Promoter Haplotypes Decipher Genetic Susceptibility to Alzheimer's Disease
Journal of Alzheimer's Disease, 2010We here demonstrate that promoter polymorphisms rs8003602 and rs3783320 of cholesterol 24S-hydroxylase (CYP46A1) were significantly associated with Alzheimer's disease (AD) in Chinese subjects. Haplotype analyses showed that haplotype CG is the risk haplotype.
Li, Y +7 more
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An Intronic CYP46A1 Polymorphism Is Associated with Alzheimer Disease in a Chinese Han Population
Journal of Molecular Neuroscience, 2012Excess cholesterol is removed from the brain via hydroxylation mediated by cholesterol 24S-hydroxylase (CYP46), which is a mechanism of maintaining cholesterol homeostasis in the brain. The CYP46A1 gene has been suggested as a genetic risk factor for sporadic late-onset Alzheimer's disease (AD).
Xiao-ming, He +6 more
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The Relationship Between CYP46A1 Polymorphism and Suicide Risk: A Preliminary Investigation
NeuroMolecular MedicineSuicide is a global public health issue, with a particularly high incidence in individuals suffering from Major Depressive Disorder (MDD). The role of cholesterol in suicide risk remains controversial, prompting investigations into genetic markers that may be implicated.
María Fernanda, Serna-Rodríguez +6 more
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