Results 91 to 100 of about 4,157 (190)

Multi‐Gene Pharmacogenomic Testing in a Community‐Based Setting Is Feasible and Reduces Total Healthcare Costs

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Pharmacogenomic (PGx) testing using multi‐gene panels (mgPGx) is documented to improve clinical outcomes; however, real‐world data on its economic impact remain limited. This study aimed to evaluate the utility and economic value of mgPGx testing among Medicare patients within a community‐based health system.
Nihal El Rouby, Josiah D. Allen, Tyler Koep, Pat McIntyre, James Kelly, Adarsh Ramesh, Anita Desai‐Naik, Jonathan Chiang, Sheena Patel, Carley Brueckner, Anna Crider, Grace Miller, Andrea Schumann, Jody Wallace, Barry Wendt, Jaime Grund   +15 more
wiley   +1 more source

Association Between ABCB1 Polymorphism and Stable Warfarin Dose Requirements in Brazilian Patients

Frontiers in Pharmacology, 2018
The ideal dose of the oral anticoagulant warfarin varies widely among patients, mainly due to genetic factors. Genetic variations that impact warfarin pharmacokinetics and the vitamin K cycle are plausible candidates for being associated with warfarin ...
Letícia C. Tavares, Leiliane R. Marcatto, Renata A. G. Soares, Jose E. Krieger, Alexandre C. Pereira, Paulo C. J. L. Santos, Paulo C. J. L. Santos   +6 more
doaj   +1 more source

Old and New Oral Anticoagulants. Pharmacological Perspective [PDF]

, 2012
A terapêutica anticoagulante oral está em mudança. A varfarina e o acenocumarol constituem ainda o padrão anticoagulante oral em muitos contextos clínicos. Mas, face às limitações dos antivitamínicos K, resultantes do lento início de ação farmacológica,
Marques da Silva, P
core   +1 more source

Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene [PDF]

, 2012
Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the most common rescue medications ...
Bleecker, Eugene R., Carey, Vincent James, Hanrahan, John P., Himes, Blanca Elena, Hu, Ruoxi, Irvin, Charles G., Israel, Elliot, Jiang, Xiaofeng, Klanderman, Barbara J., Koppelman, Gerard H., Kubo, Michiaki, Lemanske, Robert F., Lima, John J., Litonjua, Augusto Ampil, Lu, Quan, Markezich, Amy, Martinez, Fernando D., Meyers, Deborah A., Nakamura, Yusuke, Nieuwenhuis, Maartje A. E., Panettieri, Reynold A., Peters, Stephen P., Postma, Dirkje S., Senter-Sylvia, Jody, Strunk, Robert C., Su, Jessica Ann Lasky, Szefler, Stanley J., Tamari, Mayumi, Tantisira, Kelan, Vonk, Judith M., Weiss, Scott Tillman, Wu, Ann Chen, Zeiger, Robert S., Ziniti, John   +33 more
core   +5 more sources

Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People

Journal of the American Geriatrics Society, Volume 73, Issue 12, Page 3679-3689, December 2025.
This graphical abstract illustrates the annual prevalence of exposure to CPIC Level A drugs among older adults, categorized by type of pharmacogenetic recommendation. Data are presented per 1000 older individuals (A) and per 1000 prescriptions (B).
Zinan Zhao, Yuxuan Zhao, Xiaowen Hu, Xue Wang, Gengchen Wang, Xinyi Zhang, Wenliang Dong, Luwen Shi, Xiaodong Guan, Christine Y. Lu, Pengfei Jin, Xiaoyan Nie   +11 more
wiley   +1 more source

In Vitro Inhibitory Effects of Sesamin on CYP4F2 Activity.

Biological & pharmaceutical bulletin, 2020
Sesamin is a major lignan in sesame seeds, and a recent meta-analysis of controlled trials indicated that sesamin intake decreases blood pressure. The antihypertensive effect of sesamin has been suggested to be due to sesamin-mediated suppression of 20-hydroxyeicosatetraenoic acid production catalyzed by CYP4F2.
Hiroaki, Watanabe, Satoshi, Yamaori, Shinobu, Kamijo, Kaori, Aikawa, Shigeru, Ohmori   +4 more
openaire   +1 more source

Dietary and genetic influences on hemostasis in a Yup'ik Alaska Native population.

PLoS ONE, 2017
Fish and marine animals are important components of the subsistence diet of Alaska Native people, resulting in a high ω3 PUFA intake. The historical record for circumpolar populations highlights a tendency for facile bleeding, possibly related to ω3 PUFA
Nicholas T Au, Morayma Reyes, Bert B Boyer, Scarlett E Hopkins, Jynene Black, Diane O'Brien, Alison E Fohner, Joe Yracheta, Timothy Thornton, Melissa A Austin, Wylie Burke, Kenneth E Thummel, Allan E Rettie   +12 more
doaj   +1 more source

Rare variant collapsing in conjunction with mean log p-value and gradient boosting approaches applied to Genetic Analysis Workshop 17 data [PDF]

, 2011
In addition to methods that can identify common variants associated with susceptibility to common diseases, there has been increasing interest in approaches that can identify rare genetic variants.
Yauheniya Cherkas, Nandini Raghavan, Stephan Francke, Frank DeFalco, Marsha A Wilcox   +4 more
core   +1 more source

Association of genetic variants at CETP, AGER, and CYP4F2 locus with the risk of atrophic age‐related macular degeneration

Molecular Genetics & Genomic Medicine, 2020
Background Age‐related macular degeneration (AMD) is the leading cause of blindness in the elderly individuals. The etiology of AMD includes environmental and genetic factors.
Rasa Liutkeviciene, Alvita Vilkeviciute, Loresa Kriauciuniene, Mantas Banevicius, Brigita Budiene, Daiva Stanislovaitiene, Reda Zemaitiene, Vytenis P. Deltuva   +7 more
doaj   +1 more source

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes [PDF]

, 2018
Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno- and endo-biotic metabolism ...
Desta, Zeruesenay, Eadon, Michael T., Gao, Hongyu, Gufford, Brandon T., Lin, Hai, Liu, Yunlong, Robarge, Jason D., Skaar, Todd C.   +7 more
core   +1 more source