Results 111 to 120 of about 4,157 (190)

Vitamin K: Metabolism, Genetic Influences, and Chronic Disease Outcomes

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Vitamin K exists in two natural isoforms: phylloquinone (PK, vitamin K1) and menaquinones (MKs, vitamin K2), and is an essential cofactor for the post‐translational carboxylation of vitamin K‐dependent proteins (VKDPs). VKDPs are implicated in various physiological processes, including blood coagulation, calcium homeostasis, as well as metabolic and ...
Montana Dupuy, Nicola P. Bondonno, Pratik Pokharel, Allan Linneberg, Itamar Levinger, Carl Schultz, Jonathan M. Hodgson, Marc Sim   +7 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Enzymes [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Fabbro, D, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +151 more
core   +4 more sources

iPSC‐Derived Liver Organoids as a Tool to Study Medium Chain Acyl‐CoA Dehydrogenase Deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT Medium chain acyl‐CoA dehydrogenase deficiency (MCADD) is an inherited metabolic disease, characterized by biallelic variants in the ACADM gene. Interestingly, even with the same genotype, patients often present with very heterogeneous symptoms, ranging from fully asymptomatic to life‐threatening hypoketotic hypoglycemia.
Ligia A. Kiyuna, José M. Horcas‐Nieto, Christoff Odendaal, Miriam Langelaar‐Makkinje, Albert Gerding, Mathilde J. C. Broekhuis, Flavio Bonanini, Madhulika Singh, Dorota Kurek, Amy C. Harms, Thomas Hankemeier, Floris Foijer, Terry G. J. Derks, Barbara M. Bakker   +13 more
wiley   +1 more source

Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration

Journal of Ophthalmology, 2018
Background. The aetiology and pathophysiology of optic neuritis (ON) is not absolutely clear but genetic and inflammatory factors may be also involved in its development.
Mantas Banevicius, Alvita Vilkeviciute, Brigita Glebauskiene, Loresa Kriauciuniene, Rasa Liutkeviciene   +4 more
doaj   +1 more source

Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases

BMC Cardiovascular Disorders, 2018
Background Inconsistent conclusions have been reported for the genetic relationship between CYP4F2 (Cytochrome P450 Family 4 Subfamily F Member 2) polymorphisms and the susceptibility to cardiovascular and cerebrovascular diseases. Methods We performed a
Tao Zhang, Kuiying Yu, Xuhua Li
doaj   +1 more source

Marshfield Clinic: Health Information Technology Paves the Way for Population Health Management [PDF]

, 2009
Highlights Fund-defined attributes of an ideal care delivery system and best practices, including an internal electronic health record, primary care teams, physician quality metrics and mentors, and standardized care processes for chronic care ...
Douglas McCarthy, Kimberly Mueller
core  

The role of genetics in pre-eclampsia and potential pharmacogenomic interventions [PDF]

, 2012
The pregnancy-specific condition pre-eclampsia not only affects the health of mother and baby during pregnancy but also has long-term consequences, increasing the chances of cardiovascular disease in later life.
Morgan, Linda, Williams, Paula Juliet
core   +4 more sources

Return of Clinically Actionable Pharmacogenetic Results From Molecular Tumor Board DNA Sequencing Data: Workflow and Estimated Costs

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 1017-1020, April 2025.
Pharmacogenetic testing can prevent severe toxicities from several oncology drug therapies; it also has the potential to improve the outcomes from supportive care drugs. Paired tumor and germline sequencing is increasingly common in oncology practice; these include sequencing of pharmacogenes, but the germline pharmacogenetic variants are rarely ...
Hyunwoo Koo, Tayler B. Smith, John T. Callaghan, Wilberforce Osei, Steven M. Bray, Emma M. Tillman, Mya T. Tran, Christopher A. Fausel, Bryan P. Schneider, Tyler Shugg, Todd C. Skaar   +10 more
wiley   +1 more source

20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice [PDF]

, 2012
Background Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma.
Blair, Ian A., Christmas, Peter, Cooper, Philip R., Douaidy, Karim, Mesaros, A. Clementina, Mittelman, Michael A., Panettieri, Reynold A., Soberman, Roy Jason, Stark, Christopher M., Zhang, Jie   +9 more
core   +1 more source

Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides

Journal of Lipid Research, 2004
CYP4F isoforms are involved in the oxidation of important cellular mediators such as leukotriene B4 (LTB4) and prostaglandins. The proinflammatory agent LTB4 and cytotoxic leukotoxins have been associated with several inflammatory diseases.
Valérie Le Quéré, Emmanuelle Plée-Gautier, Philippe Potin, Stéphanie Madec, Jean-Pierre Salaün   +4 more
doaj   +1 more source