Clinical and Applied Thrombosis/Hemostasis, 2020 Despite the development of new oral agents over the last decade, vitamin K antagonists (VKAs) remain the most widely used anticoagulants for treating and preventing thromboembolism worldwide.
Mario Rojo MSc +19 more
doaj +1 more source
Impact of the Interaction between 3′-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes [PDF]
, 2012 Genetic variation in the expression of human XMETs leads to inter-individual variability in metabolism of therapeutic agents as well as differed susceptibility to various diseases.
David A Flockhart +7 more
core +2 more sources
Impact of Genetic Factors (CYP2C9, VKORC1 and CYP4F2) on Warfarin Dose Requirement in the Turkish Population [PDF]
, 2013 WOS: 000314915200011PubMed ID: 23061746Warfarin has a narrow therapeutic index and displays marked person-to-person variation in dose requirement. Functional polymorphisms at candidate genes can therefore offer utility as biomarkers to individualize ...
Demirci, Yeliz +6 more
core +1 more source
Medicine, 2019 Abstract Prosthetic Valve Thrombosis (PVT), in spite of the advances in the valve design and the material used, remains a serious complication of mechanical cardiac valve replacement. The factors influencing the development of PVT are: thrombogenicity of the valve, hemodynamics of the transprosthetic blood flow and ineffective ...
SR, Kalpana +5 more
openaire +2 more sources
The Cutaneous Lesions of Dioxin Exposure: Lessons from the Poisoning of Victor Yushchenko [PDF]
, 2017 Several million people are exposed to dioxin and dioxin-like compounds, primarily through food consumption. Skin lesions historically called "chloracne” are the most specific sign of abnormal dioxin exposure and classically used as a key marker in humans.
Barde, Caroline +15 more
core
Multi-Species Gene Networks and Drosophila Ethanol Sedation [PDF]
, 2014 Alcohol use disorders (AUDs) are major health issues with few known genetic explanations. This project used the fruit fly (Drosophila melanogaster) model to identify genes and gene networks that influence alcohol intoxication, a phenotype related to ...
Kollah, Arnavaz
core +1 more source
GENOTIPIZACIJA VKORC1, CYP4F2, CYP2C9 NA VZORCU SPLOŠNE POPULACIJE
, 2012 Namen diplomske naloge je določiti genotipe specifičnih enonukleotidnih polimorfizmov tarčnih genov, ki so odgovorni za višji ali nižji začetni odmerek varfarina. To so VKORC1-1639G>A, CYP2C92-430C>T, CYP2C93-1075A>C, CYP4F2-132C>T. Varfarin je učinkovina, oralni antikoagulant, ki se predpisuje bolnikom z pljučno embolijo, globoko vensko trombozo ...
openaire +1 more source
Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina). [PDF]
, 2013 The relationship between anticoagulant rodenticides and the gene for vitamin K epoxide reductase has been extensively studied. The significance of mutations in Vkorc1 on the degree of response to anticoagulants is controversial.
Espinosa, Maria Beatriz
core
Expression of arachidonic acid-metabolizing cytochrome P450s in human megakaryocytic Dami cells [PDF]
, 2013 core +1 more source
The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real‐World Setting [PDF]
, 2017 Beitelshees, AL +26 more
core +1 more source