The fatty acid omega hydroxylase genes (CYP4 family) in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD): An RNA sequence database analysis and review. [PDF]
Biochem PharmacolLeahy C +9 more
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Identification of key genes and diagnostic model associated with circadian rhythms and Parkinson's disease by bioinformatics analysis. [PDF]
Front Aging NeurosciZhang J +7 more
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Dynamic star allele definitions in Pharmacogenomics: impact on diplotype calls, Phenotype predictions and statin therapy recommendations. [PDF]
Front Pharmacolvan der Maas S +4 more
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Impact of Genetic Variants on Pregabalin Pharmacokinetics and Safety. [PDF]
Pharmaceuticals (Basel)Calleja S +9 more
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CYP2C9, CYP4F2, VKORC1 Gene Polymorphism in Buryat Population
Russian Journal of Genetics, 2020The allele and genotype frequency distribution at polymorphic loci rs1799853 (430C>T) and rs1057910 (A1075C) of the CYP2C9 gene, rs2108622 (1347C>T) of the CYP4F2 gene, and rs9923231 (1639G>A) of the VKORC1 gene in the Buryat population was examined. The study involved 197 volunteers living in the Republic of Buryatia: 124 woman and 73 men, average age
A. Yu. Sambyalova +5 more
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Functional polymorphism in human CYP4F2 decreases 20-HETE production
Physiological Genomics, 200720-Hydroxyeicosatetraenoic acid (20-HETE) plays an important role in the regulation of renal tubular and vascular function and a deficiency in the renal formation of 20-HETE has been linked to the development of hypertension. The cytochrome P450 4F2 ( CYP4F2) gene encodes for the major CYP enzyme responsible for the synthesis of 20-HETE in the human ...
David E, Stec +3 more
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Characterization of Human Liver Leukotriene B4 -Hydroxylase P450 (CYP4F2)
Journal of Biochemistry, 2000We previously reported the cloning of a human liver leukotriene B(4) (LTB(4)) omega-hydroxylase P450 designated CYP 4F2 [Kikuta et al. (1994) FEBS Lett. 348, 70-74]. However, the properties of CYP 4F2 remain poorly defined. The preparation solubilized using n-octyl-beta-D-glucopyranoside from microsomes of CYP 4F2-expressing yeast cells catalyzes v ...
Y, Kikuta, E, Kusunose, M, Kusunose
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Genetic polymorphisms of VKORC1, CYP2C9, CYP4F2 in Bai, Tibetan Chinese.
Die Pharmazie, 2012VKORC1, CYP2C9 and CYP4F2 are three critical genes associated with inter-individual variation of warfarin dose. Many dosing algorithms containing these gene polymorphisms and demographic characteristics have been set up for better use of warfarin. However, with distinct gene mutation frequencies among different ethnics, dosing algorithms differ greatly.
W T, Zeng +7 more
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Influence of CYP4F2 rs2108622 (V433M) on Warfarin Dose Requirement in Asian Patients
Drug Metabolism and Pharmacokinetics, 2011Warfarin exhibits wide interpatient variability in dosing requirements. Recent studies have shown a novel polymorphism (rs2108622, V433M) in the CYP4F2 gene to be associated with variability in warfarin requirements in Caucasians. The purpose of this study was to evaluate the impact of rs2108622 on warfarin dose requirements in the Asian population ...
Onkar, Singh +4 more
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