Results 181 to 190 of about 4,157 (190)

Ketoconazole Increases Fingolimod Blood Levels in a Drug Interaction via CYP4F2 Inhibition

The Journal of Clinical Pharmacology, 2009
The sphingosine‐1‐phosphate receptor modulator fingolimod is predominantly hydroxylated by cytochrome CYP4F2. In vitro experiments showed that ketoconazole significantly inhibited the oxidative metabolism of fingolimod by human liver microsomes and by recombinant CYP4F2.
John M, Kovarik, Kiran, Dole, Gilles-Jacques, Riviere, Francoise, Pommier, Steve, Maton, Yi, Jin, Kenneth C, Lasseter, Robert L, Schmouder   +7 more
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Expression and Molecular Cloning of Human Liver Leukotriene B4 omega-Hydroxylase (CYP4F2) Gene

DNA and Cell Biology, 1999
Human liver leukotriene B4 (LTB4) omega-hydroxylase (CYP4F2) plays an important role in the metabolic inactivation and degradation of LTB4, a potent mediator of inflammation. The regulatory mechanism for the transcription of CYP4F2 has not yet been clarified.
Y, Kikuta, Y, Miyauchi, E, Kusunose, M, Kusunose   +3 more
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Regulation of CYP4F2 Leukotriene B4 ω-Hydroxylase by Retinoic Acids in HepG2 Cells

Biochemical and Biophysical Research Communications, 2000
The human CYP4F2 gene encodes a LTB4 omega-hydroxylase P450 prominently expressed in liver and kidney that functions to metabolize and inactivate the pro-inflammatory eicosanoids, LTB4 and arachidonic acid. HepG2 cells transfected with CYP4F2 -506/-6 or -1727/-6 promoter reporter constructs and treated with either all-trans (AT) or 9-cis-retinoic (9cRA)
X, Zhang, J P, Hardwick
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Dependency of phenprocoumon dosage on polymorphisms in the VKORC1, CYP2C9, and CYP4F2 genes

Pharmacogenetics and Genomics, 2011
Genome-wide association studies (GWAS) on warfarin and acenocoumarol showed that interindividual dosage variation is mainly associated with single nucleotide polymorphisms (SNPs) in VKORC1 and to a lesser extent in CYP2C9 and CYP4F2. For phenprocoumon dosage, the genes encoding CYP3A4 and ApoE might play a role.To assess the association between common ...
Teichert, M., Eijgelsheim, M., Uitterlinden, A.G., Buhre, P.N., Hofman, A., Smet, P.A. de, Visser, L.E., Stricker, B.H.C.   +7 more
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The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes

Prostaglandins & Other Lipid Mediators, 2012
The genetic basis of Metabolic syndrome (MetS) is largely unknown but a link with salt sensitivity is recognized. The cytochrome P450 isoform 4F2 (CYP4F2) is involved in renal production of 20-hydroxyeicosatethraenoic acid (20-HETE), a natriuretic substance associated with salt sensitivity.
FAVA, Cristiano, MONTAGNANA, Martina, DANESE, Elisa, Sjögren M, Almgren P, GUIDI, Giancesare, Hedblad B, Engström G, MINUZ, Pietro, Melander O.   +9 more
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A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men

Molecular Genetics and Metabolism, 2009
This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200).
Zhenyan, Fu, Tomohiro, Nakayama, Naoyuki, Sato, Yoichi, Izumi, Yuji, Kasamaki, Atsushi, Shindo, Masakatsu, Ohta, Masayoshi, Soma, Noriko, Aoi, Mikano, Sato, Yukio, Ozawa, Yitong, Ma, Koichi, Matsumoto, Nobutaka, Doba, Shigeaki, Hinohara   +14 more
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[Association on the haplotypes of CYP4F2 gene and myocardial infarction].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2010
The aim of this study was to assess the association between human CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study. A separate analysis on gender was also carried out.There were 250 MI patients and 250 control subjects genotyped for 5 SNPs of the human CYP4F2 gene (rs3093105, rs3093135, rs1558139, rs2108622 ...
Ding, Huang, Zhen-Yan, Fu, Yi-Ning, Yang, Xiang, Xie, Ying-Hong, Wang, Yi-Tong, Ma   +5 more
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Isolation of human CYP4F2 genomic DNA and its 5′ end regulatory region structure

Archives of Pharmacal Research, 1998
Human cytochrome P450 4F2 shows high regioselectivity in omega-hydroxylation of stearic acid and leukotriene B4. As a first step of its regulation study, human cytochrome P450 4F2 genomic DNA was isolated from liver of a person who was administered clofibrate for 10 years.
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Genetic Variability of CYP4F2, CYP2D6, CYP2E1, and ACE in the Chinese Yi Population

Biochemical Genetics
Genetic polymorphisms of very important pharmacogenes (VIP) are a significant factor contributing to inter-individual variability in drug therapy. The purpose of this study was to identify significantly different loci in the Yi population and to enrich their pharmacogenomic information.
Jinping, Guo, Wenqian, Zhou, Xiaoya, Ma, Yujie, Li, Huan, Zhang, Jie, Wei, Shuli, Du, Tianbo, Jin   +7 more
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Replication study of CYP4F2 association with warfarin response in an Israeli population.

Pharmacogenomics, 2012
Alison A, Motsinger-Reif, Michael J, Wagner   +1 more
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