Results 61 to 70 of about 4,157 (190)
Journal of Integrative Plant Biology, EarlyView.For a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Ruiqi Zhang +7 more
wiley +1 more source
Blood Direct PCR for Detection of CYP2C19 and CYP4F2 Variants
Precision Medicine Communications, 2022 Tatarunas et al, intended to develop and introduce into clinical practice a technique that can rapidly determine CYP2C19 rs4244285 and CTP4F2 rs3093135 genotypes from blood samples of patients. They recruited 144 consecutive patients with ST-elevated myocardial infarction for their study.
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ω‐Hydroxylation of phylloquinone by CYP4F2 is not increased by α‐tocopherol [PDF]
Molecular Nutrition & Food Research, 2013 ScopeThe objective of this study was to investigate the initial catabolic step of vitamin E and K metabolism, the ω‐hydroxylation by human cytochrome P450 4F2 (CYP4F2).Methods and resultsTocopherol (T) metabolism was compared using rat liver slices incubated with deuterated (d6)‐RRR‐α‐T (d6‐α‐T), racemic 2S‐α‐T (2S, 4′RS, 8′RS α‐T, 2S‐α‐T), or d2‐γ‐T ...
Sherry M, Farley +6 more
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GENETICS OF CLOPIDOGREL RESISTANCE: RECENT DATA
Российский кардиологический журнал, 2015 Antiplatelet therapy is one of the most importance in therapy of patients with injured coronary, cerebral and peripheral arteries. The standard of acute coronary syndrome patients treatment is double antiplatelet therapy: acetylsalicylic acid with ...
K. B. Mirzaev +2 more
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Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 953-963, April 2026.Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo +7 more
wiley +1 more source
Pharmacogenetic Warfarin Dosing Algorithm in the Russian Population
Acta Biomedica Scientifica, 2019 Background. To date, there are many pharmacogenetic algorithms for selecting the dose of warfarin. However, there is very little information about the predictive accuracy of the algorithms.
T. A. Bairova +16 more
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Combined Analysis of Phase I and Phase II Data to Enhance the Power of Pharmacogenetic Tests [PDF]
, 2016 International audienceWe show through a simulation study how the joint analysis of data from phase I and phase II studies enhances the power of pharmacogenetic tests in pharmacokinetic (PK) studies.
Bertrand, Julie +3 more
core +3 more sources
Clinician Satisfaction With Pharmacogenomics Clinical Services at a Multistate Health System
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Pharmacogenomics (PGx) utilizes genetic information to optimize medication management. Barriers to PGx implementation include limited confidence and knowledge in applying results, time constraints, and financial barriers. Clinical services across health systems vary greatly with differing consultative PGx service models.
Kristen Jacobsen +4 more
wiley +1 more source
Expression of CYP4F2 in human liver and kidney: Assessment using targeted peptide antibodies [PDF]
Archives of Biochemistry and Biophysics, 2008 P450 enzymes comprising the human CYP4F gene subfamily are catalysts of eicosanoid (e.g., 20-HETE and leukotriene B4) formation and degradation, although the role that individual CYP4F proteins play in these metabolic processes is not well defined. Thus, we developed antibodies to assess the tissue-specific expression and function of CYP4F2, one of ...
Vandana, Hirani +4 more
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Pharmacogenomics and Personalized Medicine, 2023 Kang Huang,1,* Tianyi Ma,1,* Qiang Li,1 Yilei Zhou,2 Ting Qin,1 Zanrui Zhong,1 Shilin Tang,1 Wei Zhang,1 Jianghua Zhong,1 Shijuan Lu1 1Department of Cardiovascular Medicine, Central South University Xiangya School of Medicine Affiliated Haikou ...
Huang K +9 more
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