Results 61 to 70 of about 2,623 (125)

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 89-100, January 2026.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

French‐Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Gene Panel Analysis Through Genotyping or Sequencing in Pharmacogenetics

Fundamental &Clinical Pharmacology, Volume 40, Issue 1, January 2026.
ABSTRACT Background The implementation of pharmacogenetics in clinical practice increasingly relies on multigene panels. Objectives The objective of this study is to develop harmonized recommendations for the design and analytical implementation of multigene pharmacogenetic panels, defining clinically relevant genes and associated regions of interest ...
Nicolas Picard, Estelle Ayme‐Dietrich, Sylvie Quaranta, Tiphaine Adam‐De‐Beaumais, Abd El Kader Ait Tayeb, Hugo Alarcan, Dorra Amor, David Barthelemy, Mouna Ben Sassi, Séverine Cunat, Mouna Daldoul, Hervé Delacour, Marie‐Christine Etienne‐Grimaldi, Xavier Fonrose, Benjamin Hennart, Louis Lebreton, Stephanie Malard, Céline Narjoz, Asma Omezzine, Nicolas Pallet, Léa Payen, Jeanne Petit, Fabienne Thomas, Sameh Trabelsi, Camille Tron, Céline Verstuyft, Paul Vilquin, Jean‐Christophe Boyer, Vincent Haufroid, French‐Speaking Network of Pharmacogenetics (RNPGx)   +29 more
wiley   +1 more source

Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration

Journal of Ophthalmology, 2018
Background. The aetiology and pathophysiology of optic neuritis (ON) is not absolutely clear but genetic and inflammatory factors may be also involved in its development.
Mantas Banevicius, Alvita Vilkeviciute, Brigita Glebauskiene, Loresa Kriauciuniene, Rasa Liutkeviciene   +4 more
doaj   +1 more source

Geniposide Ameliorates Hepatic Steatosis in MASLD Mice via Modulation of the CYP4A/20‐HETE Axis

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Background Metabolic dysfunction–associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disorder for which effective pharmacological interventions remain limited, particularly at early stages. Geniposide (GP), a major bioactive component derived from the fruit of Gardenia jasminoides, has been reported to exert hepatoprotective,
Ruixi Luo, Yang Yang, Xiaoqian Yang, Siman Huang, Qihang Sun, La Wang, Wenjia Wang, Ping Wang, Weiyi Tian, Peng Chen   +9 more
wiley   +1 more source

Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases

BMC Cardiovascular Disorders, 2018
Background Inconsistent conclusions have been reported for the genetic relationship between CYP4F2 (Cytochrome P450 Family 4 Subfamily F Member 2) polymorphisms and the susceptibility to cardiovascular and cerebrovascular diseases. Methods We performed a
Tao Zhang, Kuiying Yu, Xuhua Li
doaj   +1 more source

Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides

Journal of Lipid Research, 2004
CYP4F isoforms are involved in the oxidation of important cellular mediators such as leukotriene B4 (LTB4) and prostaglandins. The proinflammatory agent LTB4 and cytotoxic leukotoxins have been associated with several inflammatory diseases.
Valérie Le Quéré, Emmanuelle Plée-Gautier, Philippe Potin, Stéphanie Madec, Jean-Pierre Salaün   +4 more
doaj   +1 more source

Functionally Significant Coumarin-Related Variant Alleles and Time to Therapeutic Range in Chilean Cardiovascular Patients

Clinical and Applied Thrombosis/Hemostasis, 2020
Despite the development of new oral agents over the last decade, vitamin K antagonists (VKAs) remain the most widely used anticoagulants for treating and preventing thromboembolism worldwide.
Mario Rojo MSc, Angela Margarita Roco PhD, Marcelo Suarez MSc, Maria Alejandra Lavanderos PhD, Gabriel Verón MSc, Maria Paz Bertoglia PhD, Annabella Arredondo MD, Elena Nieto MD, Juan Carlos Rubilar MSc, Francisca Tamayo PCh, Daniela Cruz MSc, Jessica Muñoz MSc, Gabriela Bravo MSc, Patricio Salas MD, Fanny Mejías MD, Paulo Véliz MSc, Gerald Godoy MSc, Nelson Miguel Varela PhD, G. Llull MSc, Luis Abel Quiñones PhD   +19 more
doaj   +1 more source

11-Hydroxyeicosatetraenoics induces cellular hypertrophy in an enantioselective manner

Frontiers in Pharmacology
BackgroundR/S enantiomers of 11-hydroxyeicosatertraenoic acid (11-HETE) are formed from arachidonic acid by enzymatic and non-enzymatic pathways. 11-HETE is predominately formed by the cytochrome P450 1B1 (CYP1B1).
Sara A. Helal, Sara A. Helal, Ahmed A. El-Sherbeni, Ayman O. S. El-Kadi   +3 more
doaj   +1 more source

Allelic Frequency of Single-Nucleotide Polymorphisms in CYP2C9, VKORC1, and CYP4F2 Genetic Variants in Patients With Mechanical Heart Valves on Acenocoumarol Drug Therapy. [PDF]

Cureus
Najmi A, Watti V, Sadasivam B, Atal S, Kotnis A, Singh J, Santenna C, Vishwakarma S, Singh P, Zehra A, Baig U.   +10 more
europepmc   +1 more source

From Frequencies to Priorities: Interethnic Distribution of Pharmacogenetic Phenotypes as a Basis for Prioritizing Preemptive Testing in Russia's Multiethnic Population. [PDF]

Genes (Basel)
Mirzaev KB, Abdullaev SP, Tuchkova SN, Turaev FK, Selivanova LV, Fedorinov DS, Sychev DA.   +6 more
europepmc   +1 more source