Results 81 to 90 of about 4,181 (243)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Cypher - An Operating System

International Journal of Scientific Research in Engineering and Management
Abstract - Minimal Linux-based operating systems provide a practical environment for examining how user-space components interact with the kernel, but mainstream operating systems often obscure these fundamentals behind complex subsystems. Custom shells offer a clearer view of command interpretation by exposing the fundamental stages without inherited ...
Manoj S, Prof. Ashwini R, Venkateshwaran S, Yashwanth Rao H, Sanjay G K   +4 more
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Proving Cypher Query Equivalence

2025 IEEE 41st International Conference on Data Engineering (ICDE)
Graph database systems store graph data as nodes and relationships, and utilize graph query languages (e.g., Cypher) for efficiently querying graph data. Proving the equivalence of graph queries is an important foundation for optimizing graph query performance, ensuring graph query reliability, etc.
Tang, Lei, Dou, Wensheng, Zheng, Yingying, Xu, Lijie, Wang, Wei, Wei, Jun, Huang, Tao   +6 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Triángulo del neo-desarrollismo en Ecuador

Problemas del Desarrollo, 2016
La tesis neo-desarrollista se centra básicamente en un proceso de transformación socioeconómica endógena, liderado por políticas públicas. Para lograr tales fines se requieren tres estrategias conjuntas: i) fomento de un proyecto nacional; ii ...
James M. Cypher, Yolanda Alfaro
doaj  

Comparación entre Bases de Datos Orientadas a Grafo y Relacional basado en el rendimiento

Serie Científica de la Universidad de las Ciencias Informáticas, 2020
Actualmente en cada segundo y minuto en el mundo son generados grandes cantidades de datos que necesitan ser almacenados y procesados, esta información es muy variada en cuanto a la forma de almacenamiento y fuente de procedencia así como son muchos y ...
Royland Rodriguez Reyes
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Domain- and Language-Adaptable Natural Language Interface for Property Graphs

Computers
Despite the growing adoption of Property Graph Databases, like Neo4j, interacting with them remains difficult for non-technical users due to the reliance on formal query languages.
Ioannis Tsampos, Emmanouil Marakakis
doaj   +1 more source