Results 61 to 70 of about 4,795 (207)

Effects of cyproheptadine on mitral valve remodeling and regurgitation after myocardial infarction

, 2022
BACKGROUND Ischemic mitral regurgitation (MR) is primarily caused by left ventricle deformation, but leaflet thickening with fibrotic changes are also observed in the valve.
Arsenault, Marie, Paquin, Amélie, Handschumacher, Mark D., Aikawa, Elena, Levine, Robert A., Sénéchal-Dumais, Isabelle, Beaudoin, Jonathan, Clavel, Marie-Annick, Marsit, Ons, Deschênes, Valérie, Hadjadj, Sandra, Couët, Jacques, Pibarot, Philippe   +12 more
core   +1 more source

Assessment of the Acute Toxicity and Anxiolytic‐Like Effect of α‐Humulene in Adult Zebrafish (Danio rerio)

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
The monocyclic sesquiterpene α‐humulene elicited a significant anxiolytic‐like behavior in adult zebrafish and no observable acute toxicity. Pharmacological dissection suggested that this effect is independent of the benzodiazepine (BZD) binding site on the gamma‐aminobutyric acid (GABA) type A receptor (GABAAR), but it depends on the serotonin type 3 ...
Alex de Souza Borges, Italo Moura Barbosa, Jéssica Bezerra Maciel, Aluísio Marques da Fonseca, Jesyka Macedo Guedes, Jane Eire Silva Alencar de Menezes, Gyllyandeson de Araujo Delmondes, Marta Regina Kerntopf, Hélcio Silva dos Santos, Alexandre Magno Rodrigues Teixeira   +9 more
wiley   +1 more source

A clozapine-like effect of cyproheptadine on progressive ratio schedule performance [PDF]

, 2011
The atypical antipsychotic drug clozapine has multiple pharmacological actions, some of which, including 5-hydroxytryptamine (5-HT2) and histamine (H1) receptor antagonist effects, are shared by the non-selective 5-HT receptor antagonist cyproheptadine ...
L Valencia Torres, Olarte-Sánchez, Cristian, CM Bradshaw, Goudie, A., S Body, Szabadi, Elemer, Goudie, Andrew, Olarte-Sanchez, Cristian Manuel, Valencia Torres, L., HJ Cassaday, Body, S., CM Olarte-Sánchez, E Szabadi, AJ Goudie, Cassaday, H., Bradshaw, C., Bradshaw, Chris, Body, Stephanie, Cassaday, Helen J., Valencia Torres, Lourdes, Szabadi, E.   +20 more
core   +1 more source

The Role of Serotonergic Antagonists on Learning and Orientation Memory in Stressed Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Hippocampus is full of corticosteroid and serotonergic receptors, and have an important role in memory and spatial perception.
Raziye Bayramlou, Mahdi Mahdi Mohammadzadeh, Farrin babaieBabaei Balderlou   +2 more
doaj  

Anticholinergic Medication Burden Scales: A Systematic Review

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1771-1784, June 2026.
ABSTRACT Background Anticholinergic burden refers to the cumulative anticholinergic effect of all medications taken by an individual. Anticholinergic burden scales help identify patients at risk of anticholinergic adverse effects and guide prescribing. However, substantial variation exists between scales, with no gold standard identified.
Orla Vennard, Carrie Stewart, Mansi Tolia, Roy L. Soiza, Phyo K. Myint   +4 more
wiley   +1 more source

Cyproheptadine, a SET7/9 inhibitor, reduces hyperglycaemia-induced ER stress alleviating inflammation and fibrosis in renal tubular epithelial cells

, 2022
Persistent hyperglycaemia increases SET7/9 expression and endoplasmic reticulum (ER) stress which causes inflammation, apoptosis, and fibrosis in renal tubular epithelial cells leading to diabetic kidney disease (DKD).
Anil Bhanudas Gaikwad (13183593), Vishwadeep Shelke (13183590), Himanshu Sankrityayan (13183584), Ajinath Kale (13183587)   +3 more
core   +1 more source

Reversible cerebral vasoconstriction syndrome: A narrative review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1162-1180, May 2026.
Abstract Objectives/Background This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resolving within 3 months ...
Ícaro Araújo de Sousa, Abner da Silva Machado, Arthur de Oliveira Veras, Thiago Oscar Goulart, Sarah Galassi Tatsuta, Trajano Aguiar Pires Gonçalves, Eva Rocha, Octávio Marques Pontes‐Neto   +7 more
wiley   +1 more source

The role of peripheral serotonin in SARS‐CoV‐2 infectivity, COVID‐19 treatment and long COVID

Immunology &Cell Biology, Volume 104, Issue 4, Page 368-376, April 2026.
In this article, we discuss how SARS‐CoV‐2 infects the gastrointestinal tract, that enterochromaffin cells, the source of circulating serotonin, uniquely express viral entry receptors. We examine how this infection disrupts gut‐derived serotonin, contributing to gastrointestinal symptoms and disease severity, and link elevated plasma serotonin to COVID‐
Daniel W Thorpe, Lauren A Jones, Alyce M Martin, Rosemary A Coleman, Caitlin Allman, Rochelle A Peterson, Damien J Keating   +6 more
wiley   +1 more source

Cyproheptadine Angmentation of Haloperidol in Chronic Schizophrenic Patients : A Double Blind Placebo-Controlled Study

, 1995
A 6 week double-blind placebo-controlled trial of cyproheptadine augmentation of ongoing haloperidol treatment was conducted in 40 chronic schizophrenic in-patients. Cyproheptadine augmentation, compared to administration of haloperidol with placebo, did
이홍식, 송동호
core   +1 more source

Co-Enzyme Q10 and L-Carnitine in Cyclic Vomiting

Pediatric Neurology Briefs, 2011
Researchers at Childrens Hospital Los Angeles, CA conducted a retrospective chart review of 42 patients treated with co-enzyme Q10 and L-carnitine, and the addition of amitryptiline (or cyproheptadine for
J Gordon Millichap
doaj   +1 more source