Results 111 to 120 of about 10,826 (180)

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026.
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock

Intensive Care Medicine Experimental, 2017
Background Cystathionine-γ-lyase (CSE) was shown to have a regulatory role in glucose metabolism. Circulatory shock can induce metabolic stress, thereby leading to hyperglycemia and mitochondrial dysfunction.
Tamara Merz, Josef A. Vogt, Ulrich Wachter, Enrico Calzia, Csaba Szabo, Rui Wang, Peter Radermacher, Oscar McCook   +7 more
doaj   +1 more source

ON THE ROLE OF CYSTATHIONINE-γ-LYASE IN MODULATING TRANSSULFURATION PATHWAY IN THE LENS [PDF]

In Mammals transsulfuration pathway enables the conversion of homocysteine (Hcy), deriving from methionine (Met) transmetilation, into cysteine (Cys) through two steps, the first catalyzed by cystathionine β-synthase (CBS) and the second one by ...
CALVANI, ENRICA
core  

Biosynthesis of H2S and Siderophores Targeting Gram‐Negative Bacterial Resistance to Reactive Oxygen Species

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Discover how Gram‐negative bacteria develop resistance to reactive oxygen species, and how scientists aim to overcome this challenge. Abstract Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and ...
Congyang Mao, Wanyu Jin, Yiming Xiang, Yizhou Zhu, Jun Wu, Xiangmei Liu, Shuilin Wu, Wei Qiao, Kenneth M. C. Cheung, Kelvin Wai Kwok Yeung   +9 more
wiley   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

H$_{2}$S, polysulfides, and enzymes : physiological and pathological aspec [PDF]

, 2020
We have been studying the general aspects of the functions of H$_{2}$S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years.
Noriyuki Nagahara
core   +1 more source

Habitat Diversity Sustains Ecosystem Functioning in Plateau Arid‐Region Wetlands

Ecology and Evolution, Volume 15, Issue 12, December 2025.
Habitat diversity underpins both biodiversity and functional biogeochemical processes in plateau arid‐region wetlands, thereby stabilizing ecosystem functioning. These functionally complementary habitats collectively drive critical ecosystem processes.
Chenyu Wang, Haicheng Wei, Ronglei Duan, Shi Jin, Jinxin Wen, Hongyu Li, Aiying Cheng, Chunliang Gao, Hongpan Xue, Yilin Hou   +9 more
wiley   +1 more source

Sec6 mutations and the Drosophila exocyst complex [PDF]

, 2005
To allow a detailed analysis of exocyst function in multicellular organisms, we have generated sec6 mutants in Drosophila. We have used these mutations to compare the phenotypes of sec6 and sec5 in the ovary and nervous system, and we find them to be ...
Denef, Natalie, Higashi, Misao E. L., Murthy, Mala, Ranjan, Ravi, Schupbach, Trudi, Schwarz, Thomas L.   +5 more
core   +2 more sources

H2S Biogenesis by Human Cystathionine γ-Lyase Leads to the Novel Sulfur Metabolites Lanthionine and Homolanthionine and Is Responsive to the Grade of Hyperhomocysteinemia*

Journal of Biological Chemistry, 2009
Although there is a growing recognition of the significance of hydrogen sulfide (H2S) as a biological signaling molecule involved in vascular and nervous system functions, its biogenesis and regulation are poorly understood.
T. Chiku, D. Padovani, Weidong Zhu, Sangita Singh, V. Vitvitsky, R. Banerjee   +5 more
semanticscholar   +1 more source

An Improved Two‐Step Collagenase Perfusion Protocol for Isolation of Mouse Primary Hepatocytes

Future Postharvest and Food, Volume 2, Issue 4, Page 474-477, December 2025.
An improved two‐step protocol for isolation of mouse primary hepatocytes by inserting needles into the portal vein and cutting of the inferior vena cava. ABSTRACT In metabolic dysfunction‐associated steatotic liver disease (MASLD) or diabetes mechanistic studies, cellular experiments are frequently required.
Xiaopeng Li
wiley   +1 more source