Results 91 to 100 of about 412,162 (161)

Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap

Biology Open, 2015
In addition to its role in the endogenous synthesis of cysteine, cystathionine gamma-lyase (CGL) is a major physiological source of the vasorelaxant hydrogen sulfide.
Hua Jiang, K. Joseph Hurt, Kelsey Breen, Sally P. Stabler, Robert H. Allen, David J. Orlicky, Kenneth N. Maclean   +6 more
doaj   +1 more source

Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure

, 2018
Hydrogen sulfide (H2S) and NO are important gasotransmitters, but how endogenous H2S affects the circulatory system has remained incompletely understood.
Wang, N., Rabelo, L.A., István András Szijártó, Witzenrath, M., Markó, L., Diedrich, A., Christoph Tabeling, Miljkovic, J.L., Filipovic, M.R., Kamata, S., Ishii, I., Noriyuki Akahoshi, Gollasch, M., Dmitry Tsvetkov, Maik Gollasch, Shotaro Kamata, Jan Lj Miljkovic, Akahoshi, N., André Diedrich, Luiza A. Rabelo, Szijártó, I.A., Tsvetkov, D., Szijártó, I.A, Tank, J., Tabeling, C., Martin Witzenrath, Lajos Markó, Isao Ishii, Milos R. Filipovic, Ning Wang, Jens Tank   +30 more
core   +1 more source

Hydrogen sulfide/polysulfides signaling and neuronal diseases

Neurotherapeutics
Hydrogen sulfide (H2S) and polysulfides including H2Sn (n ​= 2 or more) regulate neuronal activity, vascular tone, oxytosis/ferroptosis, oxygen sensing, cancer growth and senescence.
Hideo Kimura
doaj   +1 more source

Published Interactions of the Gasotransmitters.

, 2015
HO heme oxygenase; CSE cystathionine-γ-lyase; CBS cystathionine-β-synthase; NOS nitric oxide synthase (eNOS endothelial isoform, iNOS inducible isoform, nNOS neuronal isoform).
Grazyna Chwatko (615334), Hannah K. Palliser (615332), Megan A. Kelly (453438), Rebecca M. Dyson (615331), Rafal Glowacki (615335), Joanna L. Latter (615333), Ian M. R. Wright (615336)   +6 more
core   +1 more source

Assessment of transsulfuration enzymes pattern in a human astrocytoma cell line [PDF]

, 2016
La via di transulfurazione è centrale nel metabolismo degli amminoacidi solforati, questa, attraverso l'azione di due enzimi, la cistationina-β-sintasi e la cistationine-γ-liasi permette la sintesi di cisteina a partire da serina e omocisteina. Entrambi
ROCCHICCIOLI, MARCO
core   +1 more source

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors

Frontiers in Physiology
Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi, Eita Sasaki, Hisashi Ohno, Orie Takayama, Sota Yamada, Kenjiro Hanaoka, Kenjiro Hanaoka   +6 more
doaj   +1 more source

Concurrent Overexpression of Arabidopsis thaliana Cystathionine γ‑Synthase and Silencing of Endogenous Methionine γ‑Lyase Enhance Tuber Methionine Content in Solanum tuberosum

, 2017
Potatoes (Solanum tuberosum) are deficient in methionine, an essential amino acid in human and animal diets. Higher methionine levels increase the nutritional quality and promote the typically pleasant aroma associated with baked and fried potatoes ...
Pavan Kumar (185664), Georg Jander (39383)   +1 more
core   +1 more source

Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H₂S Systems

Biomolecules
Early life stress (ELS) significantly increases the risk of chronic cardiovascular diseases and may cause neuroinflammation. This post hoc study, based on the material available from a previous study showing elevated “serum brain injury markers” in male ...
Franziska Münz, Nadja Abele, Fabian Zink, Eva-Maria Wolfschmitt, Melanie Hogg, Claus Barck, Josef Anetzberger, Andrea Hoffmann, Michael Gröger, Enrico Calzia, Christiane Waller, Peter Radermacher, Tamara Merz   +12 more
doaj   +1 more source

A cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway

, 2017
Traditionally, hydrogen sulfide (H2S) was simply considered as a toxic and foul smelling gas, but recently H2S been brought into the spot light of cardiovascular research and development.
Li, Hua, Ge, Junbo, Steve Huang, Steve Huang   +2 more
core  

Relationships Between H₂S and OT/OTR Systems in Preeclampsia

Antioxidants
Pre-eclampsia (PE) is a hypertensive pregnancy complication. Oxidative stress is hypothesized to contribute to the pathophysiology of PE. Both the hydrogen sulfide (H2S) and oxytocin (OT) systems might play a role in the pathophysiology of PE, like their
Tamara Merz, Sarah Ecker, Nicole Denoix, Oscar McCook, Stefanie Kranz, Ulrich Wachter, Edit Rottler, Thomas Papadopoulos, Christoph Fusch, Cosima Brucker, Jakob Triebel, Thomas Bertsch, Peter Radermacher, Christiane Waller   +13 more
doaj   +1 more source