Results 81 to 90 of about 412,162 (161)

Hydrogen sulfide and its role in female reproduction

Frontiers in Veterinary Science
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST).
Aneta Pilsova, Zuzana Pilsova, Barbora Klusackova, Natalie Zelenkova, Eva Chmelikova, Pavla Postlerova, Marketa Sedmikova   +6 more
doaj   +1 more source

Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production

, 2020
Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and pancreatitis.
Giuseppe Caliendo (1426144), Elisa Perissutti (1426147), Vincenzo Santagada (1426138), Luigi Servillo (508719), Elisa Magli (1426141), Ferdinando Fiorino (1426135), Beatrice Severino (1426117), Annalisa Pastore (23137), Grzegorz Popowicz (2730355), Angela Corvino (1426123), Mariarosaria Bucci (22937), Francesco Frecentese (1426120), Giuseppe Cirino (22938), Geoff Kelly (212365)   +13 more
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Screening, morphological and molecular characterization of fungi producing cystathionine γ-lyase [PDF]

, 2015
The potency for production of cystathionine γ-lyase (CGL) by the fungal isolates was screened. Among the tested twenty-two isolates, Aspergillus carneus was the potent CGL producer (6.29 U/mg), followed by A. ochraceous (6.03 U/mg), A. versicolor (2.51 U/
Ashraf El-Sayed, Salwa Khalaf, Khalaf, Salwa, El-Batrik, Mohamed, El-Sayed, Ashraf, Gamal Abdel-Hamid, Abdel-Hamid, Gamal, Mohamed El-Batrik   +7 more
core   +1 more source

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells

Frontiers in Pharmacology, 2017
Hypoxia-induced angiogenesis is a common phenomenon in many physiological and patho-physiological processes. However, the potential differential roles of three hydrogen sulfide producing systems cystathionine γ-lyase (CSE)/H2S, cystathionine β-synthase ...
Beibei Tao, Rui Wang, Chen Sun, Yichun Zhu   +3 more
doaj   +1 more source

Significance of Hydrogen Sulfide Production in the Pancreatic β-Cell

Journal of Pharmacological Sciences, 2011
.: Hydrogen sulfide (H2S) is an important signaling molecule in various mammalian cells and tissues. H2S is synthesized from l-cysteine and regulates several cellular and physiological phenomena (vasorelaxation, hormone secretion, and apoptosis) and ...
Shigeki Taniguchi, Ichiro Niki
doaj   +1 more source

Identification and characterization of a methionine γ-lyase in the calicheamicin biosynthetic cluster of micromonospora echinospora

, 2015
CalE6 is a previously uncharacterized protein involved in the biosynthesis of calicheamicins in Micromonospora echinospora. It is a pyridoxal-5′-phosphate-dependent enzyme and exhibits high sequence homology to cystathionine γ-lyases and cystathionine γ ...
Song, Haigang, Xu, Ri, Guo, Zhihong
core   +1 more source

IMMUNOHISTOCHEMICAL APPROACH REVEALS LOCALIZATION OF CYSTATHIONINE-?-LYASE AND CYSTATHIONINE-ß-SYNTHETASE IN ETHANOL-INDUCED GASTRIC MUCOSA DAMAGE IN MICE [PDF]

, 2013
Context Hydrogen sulphide (H2S) has been proved to be a neuromodulator and contributes to the maintenance of gastric mucosal integrity in damage caused by anti-inflammatory nonsteroidal drugs.
Marcellus Henrique Loiola Ponte de SOUZA, Jand-Venes Rolim MEDEIROS, Pedro Marcos Gomes SOARES, Gerly Anne de Castro BRITO   +3 more
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Activities of methionine-γ-lyase in the acidophilic archaeon “Ferroplasma acidarmanus” strain fer1 [PDF]

, 2013
Biogeochemical processes on exposed pyrite ores result in extremely high levels of sulfuric acid at these locations. Acidophiles that thrive in these conditions must overcome significant challenges, including an environment with proton concentrations at ...
Lopez-Munoz, Madeline M., Kaspar, Charles W., Khan, M., Khan, M. A., Kaspar, Charles, Hung, Kai, Hung, Kai F., Lopez-Munoz, Madeline   +7 more
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De Novo Engineering of a Human Cystathionine-γ-Lyase for Systemic l‑Methionine Depletion Cancer Therapy

, 2016
It has been known for nearly a half century that human tumors, including those derived from the nervous system such as glioblastomas, medulloblastoma, and neuroblastomas are much more sensitive than normal tissues to l-methionine (l-Met) starvation ...
Everett Stone (1371840), George Georgiou (167924), Olga Paley (2022526), Barbara Ekerdt (2022529), Nai-Kong Cheung (258264), Jian Hu (31535)   +5 more
core   +1 more source

Correlation between the cystathionine-r-lyase (CES) and the severity of peptic ulcer disease [PDF]

, 2014
Background: The infection of Helicobacter pylori (H. pylori) is one of the most important causes of gastric ulcer disease. The role of hydrogen sulfide (H2S) production in H. pylori-induced gastric ulcer disease.
Xu, Can-Xia, Wang, Fen, Chen, Xiong, Wan, Ying-Chun, Guo, Tao   +4 more
core   +1 more source