Results 61 to 70 of about 412,162 (161)

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis [PDF]

, 2019
Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an important endogenous regulator of vascular function. The aim of the present study was to investigate the control and consequences of CSE activity in endothelial cells under ...
Siuda, Daniel, Szabo, Csaba, Papapetropoulos, Andreas, Sigala, Fragiska, Randriamboavonjy, Voahanginirina, Fleming, Ingrid, Malik, Randa Abdel, Heidler, Juliana, Siragusa, Mauro, Zukunft, Sven, Luck, Bert, Wang, Dao Wen, Hu, Jiong, Chen, Chen, Wittig, Ilka, Filis, Konstantinos A., Schürmann, Christoph, Zografos, George, Wittig, Janina, Kojonazarov, Baktybek, Bibli, Sofia-Iris, Pfeilschifter, Josef, Tsilimigras, Diamantis I., Brandes, Ralf P.   +23 more
core  

Cloning and characterisation of a cystathionine β/γ-lyase from two Oenococcus oeni oenological strains

, 2010
Sulphur-containing compounds in wine have been extensively studied because of their effect on wine flavour and quality. In this study, an enzyme that degrades sulphur-containing amino acids was cloned and characterised from two Oenococcus oeni strains of
Schnell S., Irmler S., Knoll C., Du Toit M., Rauhut D., Maret du Toit, Sylvia Schnell, Caroline Knoll, Doris Rauhut, Stefan Irmler   +9 more
core   +1 more source

Characterization and Crystal Structure Elucidation of the l‐Homoserine O‐Succinyltransferase MetXS From Cupriavidus necator H16

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This study reports the identification, heterologous production, and in vitro characterization of the homoserine O‐succinyltransferase from C. necator (CnMetXS). Several biochemical parameters, including the pH and temperature optima, thermostability, substrate scope, and kinetic parameters, are determined, and a high‐resolution X‐ray structure of ...
Hannah Pia Franziska Meier, Rick Oerlemans, Henrik Terholsen, Matthew R. Groves, Lars Lauterbach, Sandy Schmidt   +5 more
wiley   +1 more source

Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review

Journal of Advanced Research, 2021
Background: Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes.
Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin   +6 more
doaj   +1 more source

The primitive protozoon trichomonas vaginalis contains two methionine γ-lyase genes that encode members of the γ-family of pyridoxal 5′-phosphate-dependent enzymes

, 1998
Methionine γ-lyase, the enzyme that catalyzes the breakdown of methionine by an α,γ-elimination reaction and is a member of the γ-family of pyridoxal 5′-phosphate-dependent enzymes, is present in high activity in the primitive protozoan parasite ...
Walker, John, Edlind, Thomas, McKie, Amanda E., Mottram, Jeremy C., Coombs, Graham H.   +4 more
core   +1 more source

AMPK‐Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT AMP‐activated protein kinase (AMPK), a key regulator of cellular energy metabolism, is activated under conditions of energy stress to restore metabolic homeostasis by promoting catabolic pathways and inhibiting anabolic processes such as lipid synthesis. Multiple key molecules involved in lipid metabolism are regulated by AMPK, and its role in
Yuying Chen, Wen Liu, Bing Luo
wiley   +1 more source

ATF6‐mediated GTPase RHOQ promotes liver cancer progression via enhancing aerobic glycolysis through PAK1 phosphorylation

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
• RHOQ is a novel direct transcriptional target of ATF6 in HCC. • High RHOQ expression is associated with unfavourable clinicopathological features and poorer PFS. • RHOQ drives HCC progression via PAK1 activation and aerobic glycolysis. • Combining the PAK1‐specific inhibitor IPA‐3 with GPC3‐targeted CAR T‐cell therapy produces a potent synergistic ...
Yuange Zheng, Wei Li, Yuxin Guo, Xilin Zhu, Ying Liu, Xiaopan Wu   +5 more
wiley   +1 more source

Role of Hydrogen Sulfide in the Pathology of Inflammation

Scientifica, 2012
Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-γ-lyase and cystathionine-β-synthase.
Madhav Bhatia
doaj   +1 more source

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study

Movement Disorders, Volume 41, Issue 10, Page 2712-2722, October 2026.
Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux, Elise Pourié, Céline Bonnet, Lucie Hopes, Solène Frismand, Myriam Bronner, Virginie Roth, Marion Wandzel, Natacha Sloboda, Laetitia Lambert, Abderrahim Oussalah, Amélia Julien, Irina Rotaru, Rosa‐Maria Guéant‐Rodriguez, Jean Louis Guéant, Carine Bossenmeyer‐Pourié, Mathilde Renaud   +16 more
wiley   +1 more source

Unlocking the Potential of Nutritional Approaches and Bioactive Compounds to Modulate Oxidative Stress and Inflammation in Systemic Arterial Hypertension

Molecular Nutrition &Food Research, Volume 70, Issue 19, 15 October 2026.
Polyphenols target oxidative stress and inflammation, improving endothelial function and reducing blood pressure in systemic arterial hypertension. Created by BioRender.com. ABSTRACT Systemic arterial hypertension (SAH) remains a leading global cause of premature death, significantly increasing the risk of cardiovascular, cerebrovascular, and renal ...
Agnes Ciafrino, Denise Mafra, Marcia Ribeiro, Karen S. Coutinho‐Wolino, Thais Ionara, Victor Côrtes, Ronaldo A. O. C. Gismondi, Ludmila F. M. F. Cardozo   +7 more
wiley   +1 more source