Results 41 to 50 of about 36,977 (144)

Cystathionine β-Synthase in Physiology and Cancer

BioMed Research International, 2018
Cystathionine β-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein ...
Haoran Zhu, S. Blake, Keefe T. Chan, R. Pearson, Jian Kang   +4 more
semanticscholar   +1 more source

The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39) [PDF]

, 2014
Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is perturbed in many disease states, including those involving mitochondrial dysfunction.
Cai, Caliendo, Campolo, Chan, Chen, Cortese-Krott, Davidson, Fox, Fu, Halliwell, Kondo, Lavu, Li, Li, Li, Li, Liu, Liu, Liu, Mani, Merighi, Mkrtchyan, Murphy, Módis, Módis, Ohtsuki, Park, Paul, Perry, Robinson, Robinson, Shibuya, Shirozu, Smith, Suzuki, Szabo, Teng, Thorson, Thurnhofer, Vacek, Vandiver, Wallace, Wang, Wang, Watanabe, Weksler, Whiteman, Whiteman, Whiteman, Whiteman, Whiteman, Whiteman, Xu, Yang, Yin   +54 more
core   +1 more source

The bacterial transposon Tn7 causes premature polyadenylation of mRNA in eukaryotic organisms: TAGKO mutagenesis in filamentous fungi [PDF]

, 2003
TAGKO is a Tn7-based transposition system for genome wide mutagenesis in filamentous fungi. The effects of transposon insertion on the expression of TAGKO alleles were examined in Magnaporthe grisea and Mycosphaerella graminicola.
Adachi, K, Hamer, JE, Hamer, L, Lo, C, Shuster, JR   +4 more
core   +1 more source

Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice [PDF]

, 2008
Hydrogen sulphide (H2S) has been involved in cardiovascular homoeostasis but data about its role in animal models of diabetic pathology are still lacking.
Brancaleone V, BUCCI MARIAROSARIA, CIRINO GIUSEPPE, De Gruttola L, ROVIEZZO FIORENTINA, Vellecco VALENTINA   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Propargylglycine inhibits hypotaurine/taurine synthesis and elevates cystathionine and homocysteine concentrations in primary mouse hepatocytes [PDF]

, 2015
Our investigation showed that hepatocytes isolated from cysteine dioxygenase knockout mice (Cdo1(−/−)) had lower levels of hypotaurine and taurine than Cdo1(+/+) hepatocytes. Interestingly, hypotaurine accumulates in cultured wild-type hepatocytes.
Halina Jurkowska, Heather B. Roman, Lawrence L. Hirschberger, Martha H. Stipanuk   +3 more
core   +1 more source

In Situ Synthesis of a Tumor Microenvironment‐Activated Radiosensitizing Cu2‐xS/LDH Probe for Photoacoustic Imaging‐Guided Radiotherapy

Advanced Science, EarlyView.
We reported a new kind of organic‐inorganic composite nanomaterial with excellent PA imaging performance after the in situ activation by hydrogen sulfide in colorectal cancer tissues, which was used for precise radiotherapy of colorectal cancer. It shows a great application potential for early diagnosis and treatment of tumor.
Kang Zhu, Qiaoqiao Wei, Ying Wu, Qingqing Li, Luntao Liu, Chunxiang Mo, Chuqiao Liu, Lichao Su, Jibin Song   +8 more
wiley   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

RpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment [PDF]

, 2016
5-FU is a chemotherapy drug commonly used for the treatment of human cancers; however drug resistance represents a major challenge for its clinical application.
Botti, Gerardo, Cagliani, Roberta, Cantile, Monica, RUSSO, ANNAPINA, RUSSO, GIULIA, Saide, Assunta   +5 more
core   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source