Results 71 to 80 of about 36,977 (144)

Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle. [PDF]

BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β-synthase (CBS)-derived H2 S within skeletal muscle.
Basso Elisabetta, Maria, Bibli Iris, Sophia, Bucci, Mariarosaria, Calderone, Vincenzo, Cirino, Giuseppe., Citi, Valentina, Cozzolino, Catia, de Dominicis, Gianfranco, Fleming, Ingrid, Mancini, Antonio, Manzo, ONORINA LAURA, Mariniello, Martina, Martelli, Alma, Panza, Elisabetta, Vallifuoco, Marianna, Vellecco, Valentina   +15 more
core   +1 more source

Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond

Journal of Biological Chemistry, 2018
Cystathionine β-synthase (CBS) is the central enzyme in the trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of the three major enzymes involved in the biogenesis of H2S.
W. Niu, Jun Wang, J. Qian, Mengying Wang, P. Wu, Fei Chen, Shasha Yan   +6 more
semanticscholar   +1 more source

Distinct contributions of O‐acetylserine sulfhydrylases to cysteine biosynthesis in Pseudomonas aeruginosa

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Cysteine biosynthesis in bacteria proceeds primarily via the de novo pathway, involving serine acetyltransferase (CysE) and O‐acetylserine sulfhydrylase (OASS). This pathway is absent in humans, and its inhibition impairs microbial fitness, virulence, and antibiotic resistance, making its enzymes attractive antimicrobial targets. Most bacteria
Noemi Massa, Flavia Catalano, Silvia Fruncillo, Francesca Troilo, Marta Mellini, Filippo Favretto, Livia Leoni, Giordano Rampioni, Alessandro Giuffrè, Adele di Matteo, Alessandra Astegno   +10 more
wiley   +1 more source

N‐Acetylcysteine‐Loaded Scaffolds and Their Role in Extracellular ROS and Redox‐Related Gene Regulation in Chondrocytes

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
This study develops N‐acetylcysteine‐loaded polycaprolactone fibers for cartilage regeneration to investigate their potential in regulating redox balance. The fibers exhibit antioxidant properties and modulate genes related to glutathione and transsulfuration pathways.
Kubra Yigit, Anthony Callanan
wiley   +1 more source

Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S [PDF]

, 2014
Activation of plasma membrane TGR5 receptors in enteroendocrine cells by bile acids is known to regulate gastrointestinal secretion and motility and glucose homeostasis.
Ancy D. Nalli, Arun J. Sanyal, Divya P. Kumar, John R. Grider, Karnam S. Murthy, Senthilkumar Rajagopal, Sunila Mahavadi, Vanitha Bala   +7 more
core   +2 more sources

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients. [PDF]

, 2016
Dialysis patients display a high cardiovascular mortality, the causes of which are still not completely explained, but are related to uremic toxicity.
Amoresano, A, Cirillo, G, Di Nunzio, A, Fontanarosa, C, Ingrosso, D., Pane, F, Perna, AF, Pucci, P, Trepiccione, F, Vigorito, C, Zacchia, M   +10 more
core   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]

, 2016
The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE, D'EMMANUELE DI VILLA BIANCA, ROBERTA, DONNARUMMA, ERMINIA, FUSCO, FERDINANDO, MIRONE, VINCENZO, MITIDIERI, EMMA, Pagliara, Valentina, RUSSO, ANNAPINA, RUSSO, GIULIA, SORRENTINO, RAFFAELLA, Tramontano, Teresa   +10 more
core   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril

Aging Cell, Volume 25, Issue 2, February 2026.
Assessment of oxygen consumption rates in young, middle‐aged, and old flies from the Drosophila B lines and long‐lived O lines revealed a significant increase in metabolic rate with aging only in B flies. Lisinopril prevented the age‐related rise in metabolic rate in B female flies.
Denise Vecchié, Robert R. H. Anholt, Trudy F. C. Mackay, Maria De Luca   +3 more
wiley   +1 more source