Results 81 to 90 of about 1,025,233 (163)

Role of Hydrogen Sulfide in the Pathology of Inflammation

Scientifica, 2012
Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-γ-lyase and cystathionine-β-synthase.
Madhav Bhatia
doaj   +1 more source

An eQTL in the cystathionine beta synthase gene is linked to osteoporosis in laying hens

, 2019
"An eQTL in the cystathionine beta synthase gene is linked to osteoporosis in laying hens" Dirk-Jan De Koning, Nazaret Dominguez-Gasca, Robert H. Fleming, Andrew Gill, Dominic Kurian, Andrew Law, Heather A.
Dunn, Ian Chisholm
core   +1 more source

Loss of the Protein Cystathionine β-Synthase During Kidney Injury Promotes Renal Tubulointerstitial Fibrosis

Kidney & Blood Pressure Research, 2017
Background/Aims: Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF.
Xiangning Yuan, Jin Zhang, Feifei Xie, Wenqing Tan, Shuting Wang, Ling Huang, Lijian Tao, Qiqi Xing, Qiongjing Yuan   +8 more
doaj   +1 more source

Factor V Leiden mutation in Turkish patients with homozygous cystathionine β‐synthase deficiency

, 2001
Venous and arterial thromboembolism can occur in patients with homocystinuria. Resistance to activated protein C, which is caused by a single point mutation in the gene for factor V, renders an individual at risk for thrombosis.
Aydodu, S.D., A. Tokatli, T. Coşkun, S. D. Aydoğdu, H. S. Kalkanoğlu, GÜRGEY, AYTEMİZ, TOKATLI, AYŞEGÜL, Kalkanolu, H.S., Cokun, T., A. Gürgey   +9 more
core   +1 more source

Current Structural Knowledge on Cystathionine β‐Synthase, a Pivotal Enzyme in the Transsulfuration Pathway

, 2020
Cystathionine β‐synthase (CBS), the first enzyme of the reverse transsulfuration pathway, catalyses the pyridoxal‐5′‐phosphate (PLP)‐dependent β‐replacement reaction that condenses l‐serine with L‐homocysteine to yield cystathionine and water.
Luis Alfonso Martinez‐Cruz, Naroa Goikoetxea‐Usandizaga, Jorge Simón, Tomas Majtan, Simón, Jorge, Astegno, Alessandra, Majtan, Tomas, Carmen Fernández‐Rodríguez, Martinez‐Cruz, Luis Alfonso, González‐Recio, Irene, Martínez‐Chantar, Maria Luz, Irene González‐Recio, Fernández‐Rodríguez, Carmen, Maria Luz Martínez‐Chantar, Goikoetxea‐Usandizaga, Naroa, Alessandra Astegno   +15 more
core   +1 more source

Cystathionine β-synthase 844ins68 Genetic Polymorphism in Spontaneous Abortion Susceptibility

Applied Medical Informatics, 2011
Aim: Genetic polymorphisms in homocysteine-related genes are subject of a large body of research in pregnancy and newborn associated pathologies. The enzyme cystationine β-synthase (CBS) is involved in the transsulfuration pathway of homocysteine to ...
Radu Anghel POPP, Tania Octavia CRIŞAN, Ioana ROTAR, Marius Florin FARCAŞ, Adrian Pavel TRIFA, Mariela Sanda MILITARU, Ioan Victor POP   +6 more
doaj  

Molecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea [PDF]

, 2002
CBS1 from Magnaporthe grisea is a structural and functional homolog of the cystathionine β-synthase (CBS) gene from Saccharomyces cerevisiae. Our studies indicated that M.
Hamer, L, Lo, SCC, Hamer, JE
core   +1 more source

A Rapid Screening Method for the Measurement of Neonatal Total Homocysteine in Dried Blood Spots by Liquid Chromatography-Tandem Mass Spectrometry

International Journal of Neonatal Screening, 2017
Homocystinuria (HCU) due to cystathionine-β-synthase deficiency is generally regarded as a rare disease, but within the Qatari population has an incidence of 1 in 1800 live births. Most newborn screening methods for HCU using dried blood spots (DBS) rely
Rose Maase, Victor Skrinska, Noura Younes, Lubna Hassan, Rola Mitri, Dietrich Matern, Piero Rinaldo, Coleman Turgeon   +7 more
doaj   +1 more source

Hydrogen sulfide reduces oxidative stress in Huntington’s disease via Nrf2

Neural Regeneration Research
The pathophysiology of Huntington’s disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic
Zige Jiang, Dexiang Liu, Tingting Li, Chengcheng Gai, Danqing Xin, Yijing Zhao, Yan Song, Yahong Cheng, Tong Li, Zhen Wang   +9 more
doaj   +1 more source