Results 71 to 80 of about 1,025,233 (163)

Mesenchymal Stem Cells Alleviate Crohn's Disease by Regulating CBS‐Mediated Ferroptosis

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
MSCs alleviate CD by regulating CBS‐mediated ferroptosis. Bioinformatics analysis identified CBS as a hub gene shared by CD and ferroptosis. In TNBS‐induced colitis mice, MSCs treatment alleviated intestinal inflammation by upregulating CBS expression, increasing GSH and GPX4 levels, and inhibiting ferroptosis.
Zhixi Huang, Xiaofang Xu, Zhou Huang, Bing Han, Dan Jiang, Xiaodan Lv, Ziqian Huang, Guangfu Lin, Fengxiang Huang, Yu Li, Lichun Han, Deyi Chen, Jianing Lin, Xiaoping Lv   +13 more
wiley   +1 more source

Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase

, 2019
Aims: The transsulfuration pathway enzymes cystathionine beta-synthase (CBS) and cystathionine gammalyaseare thought to be the major source of hydrogen sulfide (H2S).
Jakub Krijt (6422104), Jitka Sokolová (564065), Maria A Ralat (6440447), Jesse F. Gregory III (420118), Michaela Krizkova (6440446), Jana O. Kent (1898485), Jan P. Kraus (6422100), Viktor Kožich (6422106), Tomas Majtan (6422097)   +8 more
core   +1 more source

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source

Synthesis of Inhibitors of Cystathionine β-Synthase

, 2014
Hydrogen sulfide (H2S) is well known for its harmful effects to the environment, yet within the last decade evidence of its role as an endogenous gasotransmitter has surfaced. Both overproduction and underproduction of H2S can lead to detrimental health
Guajardo, Alyssa Michelle 1989-
core   +2 more sources

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells

Frontiers in Pharmacology, 2017
Hypoxia-induced angiogenesis is a common phenomenon in many physiological and patho-physiological processes. However, the potential differential roles of three hydrogen sulfide producing systems cystathionine γ-lyase (CSE)/H2S, cystathionine β-synthase ...
Beibei Tao, Rui Wang, Chen Sun, Yichun Zhu   +3 more
doaj   +1 more source

First National Expanded Genomic Newborn Screening Program in Qatar; A Pilot Study, Doha‐Heidelberg Collaboration

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2374-2380, October 2026.
Reem Alsulaiman, Sarah Okashah, Radja Messai Badji, Fatemeh Abbaszadeh, Yaser Alsarraj, Rehab Ali Abdulrahman, Noora Shahbeck, Thalib Moideen, Reema El Hassan, Fatima Al‐Hamaydeh, Einas Alkuwari, Said Ismail, Hilal Al‐ Rifai, Ghassan Abdoh, Christian P. Schaaf, Georg Hoffmann, Saad Al‐Kaabi, Wadha Al‐Muftah, Tawfeg Ben‐Omran   +18 more
wiley   +1 more source

Supplemental Material, CBS-CATH-Table_1S,_2S - Association of Cystathionine β-Synthase Gene Polymorphisms With Preeclampsia

, 2018
Supplemental Material, CBS-CATH-Table_1S,_2S for Association of Cystathionine β-Synthase Gene Polymorphisms With Preeclampsia by Mercedes de León Bautista, Mirza Romero-Valdovinos, Beatriz Zavaleta-Villa, Arony Martínez-Flores, and Angélica Olivo-Díaz in
Beatriz Zavaleta-Villa (5965601), Angélica Olivo-Díaz (5965607), Mercedes de León Bautista (5965598), Mirza Romero-Valdovinos (708151), Arony Martínez-Flores (5965604)   +4 more
core   +1 more source

High Prevalence of the I278T Mutation of the Human Cystathionine β-Synthase Detected by a Novel Screening Application

, 2001
SummaryClassical homocystinuria due to cystathionine beta-synthase deficiency is one of the disorders revealing a high risk of thromboembolic events and vascular disease.
Ralf Junker, Erik Harms, Anja Homberger, Ulrike Nowak-Goettl, Hans Koch, Michael Linnebank   +5 more
core   +1 more source