Results 21 to 30 of about 5,592 (129)

Analysis of the sulfur-regulated control of the cystathionine γ-lyase gene of Neurospora crassa

BMC Research Notes, 2012
Background Cystathionine γ-lyase plays a key role in the transsulfuration pathway through its primary reaction of catalyzing the formation of cysteine from cystathionine.
Reveal Brad S, Paietta John V
doaj   +1 more source

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

mBio, 2019
The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced
Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Jordan L. Finley, Thomas G. Verriere, Daniel P. Barry, Ginger L. Milne, Paula B. Luis, Claus Schneider, Emilio S. Rivera, Kristie Lindsey-Rose, Kevin L. Schey, Alberto G. Delgado, Johanna C. Sierra, M. Blanca Piazuelo, Keith T. Wilson   +15 more
doaj   +1 more source

Evidence of endogenously produced hydrogen sulfide (H2S) and persulfidation in male reproduction

Scientific Reports, 2022
Persulfidation contributes to a group of redox post-translational modifications (PTMs), which arise exclusively on the sulfhydryl group of cysteine as a result of hydrogen sulfide (H2S) action.
Hedvika Řimnáčová, Jiří Moravec, Miriama Štiavnická, Jiřina Havránková, Ladan Monsef, Petr Hošek, Šárka Prokešová, Tereza Žalmanová, Tereza Fenclová, Jaroslav Petr, Milena Králíčková, Jan Nevoral   +11 more
doaj   +1 more source

Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundZofenopril, a sulfhydrylated angiotensin‐converting enzyme inhibitor (ACEI), reduces mortality and morbidity in infarcted patients to a greater extent than do other ACEIs.
Erminia Donnarumma, Murtuza J. Ali, Amanda M. Rushing, Amy L. Scarborough, Jessica M. Bradley, Chelsea L. Organ, Kazi N. Islam, David J. Polhemus, Stefano Evangelista, Giuseppe Cirino, J. Stephen Jenkins, Rajan A. G. Patel, David J. Lefer, Traci T. Goodchild   +13 more
doaj   +1 more source

The therapeutic potential for targeting CSE/H2S signaling in macrophages against Escherichia coli infection

Veterinary Research, 2023
Macrophages play a pivotal role in the inflammatory response to the zoonotic pathogen E. coli, responsible for causing enteric infections. While considerable research has been conducted to comprehend the pathogenesis of this disease, scant attention ...
Shaodong Fu, Zhenglei Wang, Xiangan Han, Yuanyuan Xu, Jinfeng Miao   +4 more
doaj   +1 more source

Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis

Redox Biology, 2021
During pregnancy, estrogen (E2) stimulates uterine artery blood flow (UBF) by enhancing nitric oxide (NO)-dependent vasodilation. Cystathionine γ-lyase (CSE) promotes vascular NO signaling by producing hydrogen sulfide (H2S) and by maintaining the ratio ...
Rachael Bok, Damian D. Guerra, Ramón A. Lorca, Sara A. Wennersten, Peter S. Harris, Abhishek K. Rauniyar, Sally P. Stabler, Kenneth N. MacLean, James R. Roede, Laura D. Brown, K. Joseph Hurt   +10 more
doaj   +1 more source

A cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway

International Journal of Cardiology: Heart & Vasculature, 2015
Traditionally, hydrogen sulfide (H2S) was simply considered as a toxic and foul smelling gas, but recently H2S been brought into the spot light of cardiovascular research and development.
Steve Huang, Hua Li, Junbo Ge
doaj   +1 more source

YALI0C22088g from Yarrowia lipolytica catalyses the conversion of l‐methionine into volatile organic sulfur‐containing compounds

Microbial Biotechnology, 2021
Summary The enzymatic conversion of l‐methionine (l‐Met) into volatile organic sulfur‐containing compounds (VOSCs) plays an important role in developing the characteristic aroma of foods.
Quan‐Lu Zhao, Zhu‐Lin Wang, Lan Yang, Sai Zhang, Kai‐Zhi Jia   +4 more
doaj   +1 more source

Hydrogen Sulfide Attenuates Lymphedema Via the Induction of Lymphangiogenesis Through a PI3K/Akt‐Dependent Mechanism

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Accumulating evidence suggests that hydrogen sulfide ( H2S ), an endogenously produced gaseous molecule, plays a critical role in the regulation of cardiovascular homeostasis. However, little is known about its role in lymphangiogenesis. Thus,
Junya Suzuki, Yuuki Shimizu, Takumi Hayashi, Yiyang Che, Zhongyue Pu, Kazuhito Tsuzuki, Shingo Narita, Rei Shibata, Isao Ishii, John W. Calvert, Toyoaki Murohara   +10 more
doaj   +1 more source

Hydrogen Sulfide Levels and Nuclear Factor‐Erythroid 2‐Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Cystathionine γ‐lyase, cystathionine β‐synthase, and 3‐mercaptopyruvate sulfurtransferase are endogenous enzymatic sources of hydrogen sulfide (H2S).
Kazi N. Islam, David J. Polhemus, Erminia Donnarumma, Luke P. Brewster, David J. Lefer   +4 more
doaj   +1 more source