Results 31 to 40 of about 5,592 (129)

Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice

Redox Biology, 2017
No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake.
Isabela Finamor, Salvador Pérez, Caroline A. Bressan, Carlos E. Brenner, Sergio Rius-Pérez, Patricia C. Brittes, Gabriele Cheiran, Maria I. Rocha, Marcelo da Veiga, Juan Sastre, Maria A. Pavanato   +10 more
doaj   +1 more source

Influence of polymicroelement preparation Esmin on hydrogen sulfide levels and indices of pro- and antioxidant system in the rat myocardium of different age [PDF]

The Ukrainian Biochemical Journal, 2014
The influence of microelement preparation Esmin on hydrogen sulfide (H2S) levels, activity of H2S -producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated.
N. V. Zaichko, A. S. Olhovskiy, A. V. Melnik, P. A. Yurchenko, A. S. Grigorieva, N. F. Konahovich   +5 more
doaj   +1 more source

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF

JACC: Basic to Translational Science
Summary: Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen sulfide (H2S) bioavailability in HFpEF patients and 2 animal models: the ''2-hit'' L-NAME + high-fat diet mouse model and ZSF1
Jake E. Doiron, PhD, Mahmoud H. Elbatreek, PhD, Huijing Xia, PhD, Xiaoman Yu, MS, Natalie D. Gehred, BA, Tatiana Gromova, BS, Jingshu Chen, PhD, Ian H. Driver, PhD, Naoto Muraoka, PhD, Martin Jensen, PhD, Smitha Shambhu, MS, W.H. Wilson Tang, MD, Kyle B. LaPenna, PhD, Thomas E. Sharp, III, PhD, Traci T. Goodchild, PhD, Ming Xian, PhD, Shi Xu, PhD, Heather Quiriarte, MS, Timothy D. Allerton, PhD, Alexia Zagouras, MD, MS, Jennifer Wilcox, BS, Sanjiv J. Shah, MD, Josef Pfeilschifter, PhD, Karl-Friedrich Beck, PhD, Thomas M. Vondriska, PhD, Zhen Li, PhD, David J. Lefer, PhD   +26 more
doaj   +1 more source

Harnessing Methylselenol (CH3SeH): A Highly Effective Platform for Stimuli‐Responsive Delivery With Therapeutic Potential

Advanced Science, EarlyView.
Tools for controlled selenol delivery are crucial for exploring Se‐related biology and medicine, but compound platforms for triggerable release of CH3SeH remain lacking. Herein, we report the first general triggered platform (TD‐MSe) for efficient cyclization release of CH3SeH in live cells.
Wenfang Liang, Liyue Wang, Xuan Wang, Xinran Li, Hao Xing, Lu Sun, Zhen Xi, Long Yi   +7 more
wiley   +1 more source

Production of hydrogen sulfide from D-cysteine and its therapeutic potential

Frontiers in Endocrinology, 2013
Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney and brain from ischemic insult. H2S
Norihiro eShibuya, Hideo eKimura
doaj   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Emerging insights into amino acid metabolism in the heart: implications for cardiovascular diseases and therapeutic targeting

British Journal of Pharmacology, EarlyView.
As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam, Hongyuan Zhang, Min Zi, Chen Chen, Junfang Wu, Andreas Papapetropoulos, Xin Wang   +6 more
wiley   +1 more source

Hydrogen sulfide metabolism regulates endothelial solute barrier function

Redox Biology, 2016
Hydrogen sulfide (H2S) is an important gaseous signaling molecule in the cardiovascular system. In addition to free H2S, H2S can be oxidized to polysulfide which can be biologically active.
Shuai Yuan, Sibile Pardue, Xinggui Shen, J. Steven Alexander, A. Wayne Orr, Christopher G. Kevil   +5 more
doaj   +1 more source