Results 61 to 70 of about 5,592 (129)

Significance of Hydrogen Sulfide Production in the Pancreatic β-Cell

Journal of Pharmacological Sciences, 2011
.: Hydrogen sulfide (H2S) is an important signaling molecule in various mammalian cells and tissues. H2S is synthesized from l-cysteine and regulates several cellular and physiological phenomena (vasorelaxation, hormone secretion, and apoptosis) and ...
Shigeki Taniguchi, Ichiro Niki
doaj   +1 more source

Allosteric activators of cystathionine γ lyase to augment endogenous hydrogen sulfide and inhibit pathologic calcification

Pharmacological Research
Hydrogen sulfide (H₂S), a gasotransmitter naturally produced in the body by enzymes such as cystathionine γ lyase (CSE), helps reduce inflammation, oxidative stress, and abnormal tissue calcification.
Sonia Nasi, Driss Ehirchiou, Cindy Blatter, Veronique Chobaz, Stefan Germann, Alexandra Brandenberger, Elias Bommeli, Emiko Uchikawa, Giuseppe Cirino, Rainer Riedl, Alexander So, Nathalie Busso   +11 more
doaj   +1 more source

Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap

Biology Open, 2015
In addition to its role in the endogenous synthesis of cysteine, cystathionine gamma-lyase (CGL) is a major physiological source of the vasorelaxant hydrogen sulfide.
Hua Jiang, K. Joseph Hurt, Kelsey Breen, Sally P. Stabler, Robert H. Allen, David J. Orlicky, Kenneth N. Maclean   +6 more
doaj   +1 more source

Hydrogen sulfide/polysulfides signaling and neuronal diseases

Neurotherapeutics
Hydrogen sulfide (H2S) and polysulfides including H2Sn (n ​= 2 or more) regulate neuronal activity, vascular tone, oxytosis/ferroptosis, oxygen sensing, cancer growth and senescence.
Hideo Kimura
doaj   +1 more source

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors

Frontiers in Physiology
Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi, Eita Sasaki, Hisashi Ohno, Orie Takayama, Sota Yamada, Kenjiro Hanaoka, Kenjiro Hanaoka   +6 more
doaj   +1 more source

Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H₂S Systems

Biomolecules
Early life stress (ELS) significantly increases the risk of chronic cardiovascular diseases and may cause neuroinflammation. This post hoc study, based on the material available from a previous study showing elevated “serum brain injury markers” in male ...
Franziska Münz, Nadja Abele, Fabian Zink, Eva-Maria Wolfschmitt, Melanie Hogg, Claus Barck, Josef Anetzberger, Andrea Hoffmann, Michael Gröger, Enrico Calzia, Christiane Waller, Peter Radermacher, Tamara Merz   +12 more
doaj   +1 more source

Relationships Between H₂S and OT/OTR Systems in Preeclampsia

Antioxidants
Pre-eclampsia (PE) is a hypertensive pregnancy complication. Oxidative stress is hypothesized to contribute to the pathophysiology of PE. Both the hydrogen sulfide (H2S) and oxytocin (OT) systems might play a role in the pathophysiology of PE, like their
Tamara Merz, Sarah Ecker, Nicole Denoix, Oscar McCook, Stefanie Kranz, Ulrich Wachter, Edit Rottler, Thomas Papadopoulos, Christoph Fusch, Cosima Brucker, Jakob Triebel, Thomas Bertsch, Peter Radermacher, Christiane Waller   +13 more
doaj   +1 more source

Cystathionine γ-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism. [PDF]

Int J Mol Sci, 2023
Araki S, Takata T, Ono K, Sawa T, Kasamatsu S, Ihara H, Kumagai Y, Akaike T, Watanabe Y, Tsuchiya Y.   +9 more
europepmc   +1 more source

Naphthyl-Substituted Indole and Pyrrole Carboxylic Acids as Effective Antibiotic Potentiators-Inhibitors of Bacterial Cystathionine γ-Lyase. [PDF]

Int J Mol Sci, 2023
Kuzovlev AS, Zybalov MD, Golovin AV, Gureev MA, Kasatkina MA, Biryukov MV, Belik AR, Silonov SA, Yunin MA, Zigangirova NA, Reshetnikov VV, Isakova YE, Porozov YB, Ivanov RA.   +13 more
europepmc   +1 more source

Structural basis of the inhibition of cystathionine γ-lyase from Toxoplasma gondii by propargylglycine and cysteine. [PDF]

Protein Sci, 2023
Fernández-Rodríguez C, Conter C, Oyenarte I, Favretto F, Quintana I, Martinez-Chantar ML, Astegno A, Martínez-Cruz LA.   +7 more
europepmc   +1 more source