Frontiers in Immunology, 2018 Chronic inflammation contributes to tumor initiation in colitis-associated colorectal cancer (CRC). Indeed, inflammatory bowel disease (IBD) patients show an increased risk of developing CRC.
Paola De Cicco +4 more
doaj +1 more source
RpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment [PDF]
, 2016 5-FU is a chemotherapy drug commonly used for the treatment of human cancers; however drug resistance represents a major challenge for its clinical application.
Botti, Gerardo +5 more
core +1 more source
BiomoleculesLeukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta +4 more
doaj +1 more source
The bacterial transposon Tn7 causes premature polyadenylation of mRNA in eukaryotic organisms: TAGKO mutagenesis in filamentous fungi [PDF]
, 2003 TAGKO is a Tn7-based transposition system for genome wide mutagenesis in filamentous fungi. The effects of transposon insertion on the expression of TAGKO alleles were examined in Magnaporthe grisea and Mycosphaerella graminicola.
Adachi, K +4 more
core +1 more source
Domain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases
PLoS ONE, 2014 Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine. Although the pathway itself is well conserved among eukaryotes, properties of eukaryotic CBS enzymes vary greatly.
Majtan, Tomas +5 more
openaire +6 more sources
The Effects of Cocaine on Different Redox Forms of Cysteine and Homocysteine, and on Labile, Reduced Sulfur in the Rat Plasma Following Active versus Passive Drug Injections [PDF]
, 2013 Received: 28 November 2012 / Revised: 19 April 2013 / Accepted: 6 May 2013 / Published online: 16 May 2013 The Author(s) 2013. This article is published with open access at Springerlink.comThe aim of the present studies was to evaluate cocaine ...
A Madayag +80 more
core +2 more sources
Neurobiology of Disease, 2006 Recent epidemiological and clinical data suggest that elevated serum homocysteine levels may increase the risk of developing Alzheimer's disease (AD), but the underlying mechanisms are unknown.
Javier Pacheco-Quinto +8 more
doaj +1 more source
Down Syndrome: Development Of A Non-Invasive Prenatal Dna Screening Test Using Superoxide Dismutase 1 Gene In Maternal Blood And Detection Of Cystathionine P-Synthase Gene Mutations [PDF]
, 2004 Down syndrome or Trisomy 21, is the most commonly occurring genetic disorder that stems from the failure of ·chromosome 21 to segregate normally during meiosis, resulting in an individual carrying an extra copy of chromosome 21.
Karuppiah, Thilakavathy
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ON THE ROLE OF CYSTATHIONINE-γ-LYASE IN MODULATING TRANSSULFURATION PATHWAY IN THE LENS [PDF]
In Mammals transsulfuration pathway enables the conversion of homocysteine (Hcy), deriving from methionine (Met) transmetilation, into cysteine (Cys) through two steps, the first catalyzed by cystathionine β-synthase (CBS) and the second one by ...
CALVANI, ENRICA
core
Genetic variants of methionine metabolism and X-ALD phenotype generation: results of a new study sample [PDF]
, 2018 X-linked adrenoleukodystrophy (X-ALD) is the most common inherited leukodystrophy. Nevertheless, no genotype-phenotype correlation has been established so far.
Aubourg, Patrick +6 more
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