Results 141 to 150 of about 555,922 (178)

Special Issue "Bioactive Compounds in the Prevention of Chronic Diseases". [PDF]

Int J Mol Sci
Moreno DA, Ruiz-Alcaraz AJ, Maycotte P.
europepmc   +1 more source

Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity [PDF]

European Journal of Pharmacology, 2012
Clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity. Primarily, lysosomal phospholipidosis, intracellular oxidative stress and heightened inflammation have been implicated.
Robert Tumwesigye Kinobe
exaly   +3 more sources

Inhibition of cystathionine-gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles

Acta Physiologica, 2023
AbstractAimIn extracerebral vascular beds cystathionine‐gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H2S) producing enzyme in the intracerebral arterioles remain poorly understood. We hypothesized a similar function in the intracerebral arterioles.MethodsIntracerebral arterioles were isolated from wild ...
Frantz Poulsen, Jane Stubbe, Kristina Lyngsø   +2 more
exaly   +5 more sources

Cystathionine gamma-lyase expression is regulated by exogenous hydrogen peroxide in the mammalian cells. [PDF]

Gene Expression, 2013
Hydrogen sulfide (H2S), as an endogenous signaling molecule in mammals, shows a variety of biological effects. Cystathionine gamma-lyase (CSE)/H2S pathway has been implicated in scavenging reactive oxygen species (ROS) in the mammalian cells. Therefore, we first investigated the regulatory effects of exogenously applied hydrogen peroxide (H2O2) on CSE ...
Shilong Wang, Maoxian Wang
exaly   +3 more sources

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Development of cystathionine gamma-lyase-specific microRNAs

Science Bulletin, 2015
The gasotransmitter role of H2S in mammalian has been extensively studied, and cystathionine gamma-lyase (CSE) is the major H2S-producing enzyme in vascular system. Dysregulation of CSE/H2S system was found in various pathophysiological conditions.
Shuangshuang Li, Guangdong Yang
exaly   +2 more sources

The therapeutic potential of cystathionine gamma-lyase in temporomandibular inflammation-induced orofacial hypernociception

Physiology and Behavior, 2018
Hydrogen sulfide (H2S) is an endogenous neuromodulator produced mainly by the enzyme cystathionine gamma-lyase (CSE) in peripheral tissues. A pronociceptive role of endogenously produced H2S has been previously reported by our group in a model of orofacial inflammatory pain.
Glauce Nascimento, Bruna M Santos, Luiz G. S. Branco   +2 more
exaly   +3 more sources

Is cystathionine gamma-lyase protein expressed in the heart?

Biochemical and Biophysical Research Communications, 2012
Hydrogen sulfide (H(2)S) has emerged as an important gasotransmitter, offering protection against ischemia-reperfusion damage to the heart. Cystathionine gamma-lyase (CSE) is believed to be the major H(2)S-generating enzyme in the heart. Quite contrary to the general contemplation, CSE protein in cardiac tissues has not been convincingly detected and ...
Ming, Fu, Weihua, Zhang, Guangdong, Yang, Rui, Wang   +3 more
openaire   +2 more sources

Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency

Antioxidants & Redox Signaling, 2017
Aims: The pathogenic mechanisms for the higher prevalence of allergic asthma in children than in adults have not been settled. The aim of the present study is to examine whether the age-dependent development of allergic asthma is caused by age-dependent expression of cystathionine gamma ...
Peipei, Wang, Lingyun, Wu, Yongjun, Ju, Ming, Fu, Tian, Shuang, Zhongming, Qian, Rui, Wang   +6 more
openaire   +2 more sources

Cystathionine gamma‐lyase aggravates periodontal damage in traumatic occlusion mouse models

Journal of Periodontal Research, 2020
AbstractBackground and objectiveThough impacts of traumatic occlusion (TO) on periodontal tissues and roles of cystathionine γ‐lyase (Cth) gene in the regulation of bone homeostasis have been studied by many, no consensus has been reached so far on whether TO deteriorates the periodontium and precise roles of Cth in occlusal trauma.
Liyuan Chen, Caizhu Lu, Yongmei Hua
openaire   +2 more sources

Cystathionine γ-lyase from Streptomyces phaeochromoǵenes

1987
Publisher Summary This chapter discusses the determination of cystathionine γ- Lyase from streptomyces phaeochromogenes. Cystathionine γ-lyase was first purified and crystallized from rat liver, but is also widely distributed among fungi. The microbial enzyme is purified and crystallized from Streptomyces phaeochromogenes (IFO 3105).
T, Nagasawa, H, Kanzaki, H, Yamada
openaire   +2 more sources