Results 41 to 50 of about 1,391 (117)

An Improved Two‐Step Collagenase Perfusion Protocol for Isolation of Mouse Primary Hepatocytes

Future Postharvest and Food, Volume 2, Issue 4, Page 474-477, December 2025.
An improved two‐step protocol for isolation of mouse primary hepatocytes by inserting needles into the portal vein and cutting of the inferior vena cava. ABSTRACT In metabolic dysfunction‐associated steatotic liver disease (MASLD) or diabetes mechanistic studies, cellular experiments are frequently required.
Xiaopeng Li
wiley   +1 more source

Investigation of the association of cystathionine gamma-lyase (CTH) and vitamin D-binding protein (GC) genes polymorphisms with preeclampsia in some pregnant women attending prenatal care at a general hospital in Lagos Nigeria

Science World Journal
Preeclampsia is associated with high maternal and foetal morbidity and mortality. Studies have demonstrated that polymorphisms in the genes that regulate vascular dynamics may play vital roles in the development of chronic hypertension and preeclampsia.
Igbalaye, Jimoh O., Wusu, Adedoja D., Oyedapo, Abiola F., Ajape, Azeezat O., Shakunle, Adebusola, Fatai, Azeez A., Rotimi, Solomon O.   +6 more
openaire   +2 more sources

Targeting hepatic stellate cells to prevent or reverse liver fibrosis [PDF]

, 2020
Activation of stellate cells as a target for the treatment of liver fibrosisIn his thesis, Zhang introduces the crucial role of hepatic stellate cell activation in the development of liver fibrosis.
Zhang, Mengfan
core   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska   +12 more
wiley   +1 more source

Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys

Aging Cell, Volume 24, Issue 12, December 2025.
Here we show shared and depot‐specific adaptations to life‐long CR in subcutaneous and visceral adipose depots from advanced‐age male rhesus monkeys. Transcriptomics reveal differences between the depots, as well as shared and distinct CR‐responsive pathways.
Josef P. Clark, Timothy W. Rhoads, Sean J. McIlwain, Michael A. Polewski, Derek M. Pavelec, Ricki J. Colman, Rozalyn M. Anderson   +6 more
wiley   +1 more source

Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians. [PDF]

, 2015
Plasma homocysteine, a metabolite involved in key cellular methylation processes seems to be implicated in cognitive functions and cardiovascular health with its high levels representing a potential modifiable risk factor for Alzheimer’s disease (AD ...
Baiyewu, Olusegun, Doraiswamy, P. Murali, Foroud, Tatiana M., Gao, Sujuan, Gureje, Oye, Hall, Kathleen S., Hendrie, Hugh C., Kaddurah-Daouk, Rima, Kim, Sungeun, Kling, Mitchel A., Lai, Dongbing, Lane, Katie, Murrell, Jill R., Nho, Kwangsik, Ogunniyi, Adesola, Ramanan, Vijay K., Saykin, Andrew J., Unverzagt, Frederick W.   +17 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Hydrogen sulphide production in healthy and ulcerated gastric mucosa of rats [PDF]

, 2017
Hydrogen sulphide (H2S) is produced endogenously via two enzymes dependent on pyridoxal phosphate (PLP): cystathionine beta-synthase (CBS, EC 4.2.1.22), cystathionase γ-liase (CTH, EC 4.4.1.1), and a third, 3-mercaptopyruvate sulfurtransferase (MPST, EC ...
Bronowicka-Adamska, Patrycja, Brzozowski, Tomasz, Kwiecień, Sławomir, Magierowska, Katarzyna, Magierowski, Marcin, Wróbel, Maria   +5 more
core   +1 more source

Contrasting Effects of Probiotic Yogurt and Brown Yogurt on the Urinary Metabolites and Gut Microbial Function of Healthy Adults

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
We identified differing metabolic responses to different types of yogurt. Brown yogurt mainly modulated pathways associated with human and gut microbial ammonia metabolism, whereas probiotic yogurt mainly affected amino acid metabolism. ABSTRACT Consuming yogurt is beneficial for healthy people, but few studies have evaluated the interactions among ...
Si Ting Chen, Tie Min Jiang, Yu Chun Wang, Xia Qi Xiong, Jun Ying Zhao, Li Jun Chen   +5 more
wiley   +1 more source

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index

Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.
We analyzed colostrum and breast milk from 47 mothers to see how proteins change over time and with maternal health. Colostrum had more immune proteins, while mature milk had proteins linked to growth support. Gestational diabetes and higher BMI altered the protein composition.
Timo Seitz, Jenni Viitaharju, Chouaib Benchraka, Johannes Merilahti, Marko Kalliomäki, Lauri Polari, Diana Toivola, Leo Lahti, Otto Kauko, Kirsi Laitinen   +9 more
wiley   +1 more source