Results 31 to 40 of about 937 (97)

Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding

Scientific Reports
Gastric cancer (GC), known for its high incidence and poor prognosis, urgently necessitates the identification of reliable prognostic biomarkers to enhance patient outcomes.
Haishun Qu, Yunxiao Liang, Quan Guo, Ling Lu, Yanwei Yang, Weicheng Xu, Yitian Zhang, Yijue Qin   +7 more
doaj   +1 more source

An Improved Two‐Step Collagenase Perfusion Protocol for Isolation of Mouse Primary Hepatocytes

Future Postharvest and Food, Volume 2, Issue 4, Page 474-477, December 2025.
An improved two‐step protocol for isolation of mouse primary hepatocytes by inserting needles into the portal vein and cutting of the inferior vena cava. ABSTRACT In metabolic dysfunction‐associated steatotic liver disease (MASLD) or diabetes mechanistic studies, cellular experiments are frequently required.
Xiaopeng Li
wiley   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska   +12 more
wiley   +1 more source

Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys

Aging Cell, Volume 24, Issue 12, December 2025.
Here we show shared and depot‐specific adaptations to life‐long CR in subcutaneous and visceral adipose depots from advanced‐age male rhesus monkeys. Transcriptomics reveal differences between the depots, as well as shared and distinct CR‐responsive pathways.
Josef P. Clark, Timothy W. Rhoads, Sean J. McIlwain, Michael A. Polewski, Derek M. Pavelec, Ricki J. Colman, Rozalyn M. Anderson   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Contrasting Effects of Probiotic Yogurt and Brown Yogurt on the Urinary Metabolites and Gut Microbial Function of Healthy Adults

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
We identified differing metabolic responses to different types of yogurt. Brown yogurt mainly modulated pathways associated with human and gut microbial ammonia metabolism, whereas probiotic yogurt mainly affected amino acid metabolism. ABSTRACT Consuming yogurt is beneficial for healthy people, but few studies have evaluated the interactions among ...
Si Ting Chen, Tie Min Jiang, Yu Chun Wang, Xia Qi Xiong, Jun Ying Zhao, Li Jun Chen   +5 more
wiley   +1 more source

Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis

Scientific Reports
Sodium aescinate (SA), a natural plant extract with various bioactivities, is widely used to treat oedema and inflammation in clinics. However, adverse events, including liver injury, kidney injury, and phlebitis, have been reported in patients with SA ...
Chen Xi, Jie Zhou, Xin Zheng, Xiaoyi Fu, Minjuan Xie   +4 more
doaj   +1 more source

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index

Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.
We analyzed colostrum and breast milk from 47 mothers to see how proteins change over time and with maternal health. Colostrum had more immune proteins, while mature milk had proteins linked to growth support. Gestational diabetes and higher BMI altered the protein composition.
Timo Seitz, Jenni Viitaharju, Chouaib Benchraka, Johannes Merilahti, Marko Kalliomäki, Lauri Polari, Diana Toivola, Leo Lahti, Otto Kauko, Kirsi Laitinen   +9 more
wiley   +1 more source

CSE/H2S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization‐Induced Muscle Atrophy in Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Hydrogen sulphide (H2S), a gasotransmitter synthesized by cystathionine‐γ‐lyase (CSE), exhibits antioxidant properties and may mimic exercise‐induced muscle protection. However, its mechanistic role in muscle atrophy and exercise intervention remains unclear.
Xiuru Li, Yating Huang, Xuege Yang, Sujuan Liu, Yanmei Niu, Li Fu   +5 more
wiley   +1 more source

Spatiotemporal Dynamics of Central Nervous System Diseases: Advancing Translational Neuropathology via Single‐Cell and Spatial Multiomics

MedComm, Volume 6, Issue 9, September 2025.
Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia, Quan Liu, Wenli Zhang, Jinwen Ge, Zhigang Mei   +4 more
wiley   +1 more source