Results 41 to 50 of about 937 (97)

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

Med Research, Volume 1, Issue 2, Page 239-256, September 2025.
Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan, Jing Zhang, Gaili Ji, Xiaobin Fang, Chunheng Mo   +4 more
wiley   +1 more source

Hydrogen Sulfide Promotes TAM‐M1 Polarization through Activating IRE‐1α Pathway via GRP78 S‐Sulfhydrylation to against Breast Cancer

Advanced Science, Volume 12, Issue 8, February 24, 2025.
This work indicates that GRP78 S‐sulfhydrylation mediated by H2S at Cys420 residue decreases tumor burden and inhibits lung metastasis of BC through reprogramming TAMs via activating IRE‐1α pathway, which offers new leads for interventions in TAMs reprogramming in BC.
Mingyi Ju, Weiwei Tong, Jia Bi, Xianxin Zeng, Aoshuang Qi, Mingli Sun, Jian Wen, Lin Zhao, Minjie Wei   +8 more
wiley   +1 more source

The Association Between Hyperketonemia and Reduced Circulating Hydrogen Sulfide in Children with Type 1 Diabetes, and Ketone Inhibition of Cystathionine-γ-Lyase mRNA Expression in Cultured Hepatocytes. [PDF]

Genes (Basel)
Jain SK, Parsanathan R, Justin Margret J, Gungor N, Vanchiere JA, Mhanna MJ, McVie R.   +6 more
europepmc   +1 more source

Beyond Hydrogen Sulfide and Cysteine Metabolism: Reframing Cystathionine γ-Lyase as a Potential Translational Regulator of Hypoxia-Inducible Factor-1α in Clear Cell Ovarian Carcinoma. [PDF]

Cells
El-Naggar AM.
europepmc   +1 more source

Co-targeting cystathionine gamma-lyase and mTOR: a promising therapeutic strategy in clear cell ovarian cancer. [PDF]

BMC Cancer
Wei L, El-Naggar AM, Li Y, Ding Y, Li E, Lam T, Wang Y, Turgu B, Huntsman DG.   +8 more
europepmc   +1 more source

In vivo characterization of the redox balance in IDH-wildtype glioblastomas: a J-difference edited MEGA-sLASER MRS study at 3T. [PDF]

Cancer Metab
Alcicek S, Manzhurtsev A, Thomas DC, Divé I, Weber KJ, Prinz V, Jussen D, Deelchand DK, Oeltzschner G, Ronellenfitsch MW, Steinbach JP, Hattingen E, Pilatus U, Wenger KJ.   +13 more
europepmc   +1 more source

Sulfur-Containing Amino Acid Homeostasis in the Central Nervous System: From Physiology Regulation to Metal-Induced Neurotoxicity. [PDF]

Metabolites
González-Alfonso WL, Vázquez-Cervantes GI, Flores I, Gonsebatt ME, Pérez de la Cruz G, Gómez Manzo S, Salazar A, Pineda B, Pérez de la Cruz V.   +8 more
europepmc   +1 more source

Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression. [PDF]

J Med Chem
Luo Z, Xu G, Li C, Sun Z, Chen H, Yang M, Ye Y, Chen Q, Xu B, Luo H, Sun B.   +10 more
europepmc   +1 more source

A targetable FTO/SLC7A11/CBS/CTH axis controls cysteine metabolism, growth and survival in NSCLC. [PDF]

Sci Adv
Kuganesan N, Pan M, Jiang H, Melemenidis S, Ye J, Richter S, Diehn M, Casey KM, Graves EE, Le QT, Rankin EB.   +10 more
europepmc   +1 more source

Endothelial cystathionine-γ-lyase (CTH) regulates body weight and insulin resistance in mice fed a high-fat diet. [PDF]

Redox Biol
Yagi T, Alam S, Niti SI, Pardue S, Shen X, Glawe JD, Kolluru GK, Tanaka T, Kevil CG.   +8 more
europepmc   +1 more source