Results 11 to 20 of about 894 (94)

Bioinformatic analyzes and validation of cystathionine gamma-lyase as a prognostic biomarker and related to immune infiltrates in hepatocellular carcinoma

Heliyon, 2023
Background: The role of cystathionine γ-lyase (CTH) in the prognosis and immune invasion of hepatocellular carcinoma (HCC) remains poorly understood. Methods: In this study, the clinical data of patients with HCC were analyzed, and the expression level ...
Jianfeng Xiang, Xinrui Wu, Wangrui Liu, Huagen Wei, Zhu Zhu, Shifan Liu, Chengqi Song, Qiang Gu, Shiyin Wei, Yichi Zhang   +9 more
doaj   +1 more source

Cystathionine Gamma-Lyase Regulate Psilocybin Biosynthesis in Gymnopilus dilepis Mushroom via Amino Acid Metabolism Pathways

Journal of Fungi, 2022
As a potential medicine for the treatment of depression, psilocybin has gradually attracted attention. To elucidate the molecular mechanism regulating psilocybin synthesis in Gymnopilus dilepis, ultra-performance liquid chromatography (UPLC) was used to ...
Sen Yao, Chuanzheng Wei, Hui Lin, Peng Zhang, Yuanyuan Liu, Youjin Deng, Qianhui Huang, Baogui Xie   +7 more
doaj   +1 more source

Hypertension and Aging Affect Liver Sulfur Metabolism in Rats

Cells, 2021
Hypertension and age are key risk factors for cardiovascular morbidity and mortality. Hydrogen sulfide (H2S), a gaseous transmitter, contributes significantly to regulating arterial blood pressure and aging processes.
Dominika Szlęzak, Patrycja Bronowicka-Adamska, Tomasz Hutsch, Marcin Ufnal, Maria Wróbel   +4 more
doaj   +1 more source

Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease

Redox Biology, 2018
Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial ...
Saurabh Rajpal, Pavan Katikaneni, Matthew Deshotels, Sibile Pardue, John Glawe, Xinggui Shen, Nuri Akkus, Kalgi Modi, Ruchi Bhandari, Paari Dominic, Pratap Reddy, Gopi K. Kolluru, Christopher G. Kevil   +12 more
doaj   +1 more source

Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2.

PLoS ONE, 2016
Prostaglandin reductase 2 (PTGR2) is the enzyme that catalyzes 15-keto-PGE2, an endogenous PPARγ ligand, into 13,14-dihydro-15-keto-PGE2. Previously, we have reported a novel oncogenic role of PTGR2 in gastric cancer, where PTGR2 was discovered to ...
Emily Yun-Chia Chang, Yi-Cheng Chang, Chia-Tung Shun, Yu-Wen Tien, Shu-Huei Tsai, Siow-Wey Hee, Ing-Jung Chen, Lee-Ming Chuang   +7 more
doaj   +1 more source

Investigation of the association of cystathionine gamma-lyase (CTH) and vitamin D-binding protein (GC) genes polymorphisms with preeclampsia in some pregnant women attending prenatal care at a general hospital in Lagos Nigeria

Science World Journal
Preeclampsia is associated with high maternal and foetal morbidity and mortality. Studies have demonstrated that polymorphisms in the genes that regulate vascular dynamics may play vital roles in the development of chronic hypertension and preeclampsia.
Igbalaye, Jimoh O., Wusu, Adedoja D., Oyedapo, Abiola F., Ajape, Azeezat O., Shakunle, Adebusola, Fatai, Azeez A., Rotimi, Solomon O.   +6 more
openaire   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, Volume 16, Issue 5, Page 944-965, May 2026.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

N‐Acetylcysteine‐Loaded Scaffolds and Their Role in Extracellular ROS and Redox‐Related Gene Regulation in Chondrocytes

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
This study develops N‐acetylcysteine‐loaded polycaprolactone fibers for cartilage regeneration to investigate their potential in regulating redox balance. The fibers exhibit antioxidant properties and modulate genes related to glutathione and transsulfuration pathways.
Kubra Yigit, Anthony Callanan
wiley   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

The Impact of Hydrogen Sulfide Regulatory Gene Alterations on Head and neck squamous cell carcinoma prognosis and tumor microenvironment

Egyptian Journal of Medical Human Genetics
Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally, with high morbidity and mortality due to late-stage diagnoses, treatment resistance, and recurrence. Hydrogen sulfide (H2S) metabolism, primarily regulated
Mohamed Rizwan Ghouse, Santhakumar Egambaram, Arunkumar Ramachandran, Rajesh Parsanathan   +3 more
doaj   +1 more source