Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies
MedComm, Volume 5, Issue 10, October 2024.Posttranslational modifications of proteins are involved in the development of metabolism‐related diseases such as diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease. PTMs mediates the development of diabetes mellitus by affecting insulin homeostasis, glucose metabolism, diabetic complications, gluconeogenesis, and β‐cell ...
Yunuo Yang +4 more
wiley +1 more source
Folate Network Genetic Variation, Plasma Homocysteine, and Global Genomic Methylation Content: A Genetic Association Study [PDF]
, 2013 Background: Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease.
Baccarelli, Andrea +11 more
core +1 more source
Biochemical characterization of ornithine aminotransferase and cystathionine \u3b3-lyase from Toxoplasma gondii: possible targets for drug development? [PDF]
, 2018 Toxoplasmosis is a widespread parasitic disease caused by Toxoplasma gondii, an obligate intracellular protozoa belonging to the phylum Apicomplexa. Toxoplasmosis is a major public health problem, infecting one-third of humans worldwide.
Maresi, Elena
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Alterations in one-carbon metabolism in metabolic dysfunction associated steatotic liver disease may be modified by semaglutide [PDF]
Introduction and Objectives: Disruptions in one-carbon metabolism (OCM) have been linked to cardiometabolic diseases. We evaluated alterations in OCM metabolites and enzymes and the impact of semaglutide in MASLD.
Bendtsen, Flemming +23 more
core +1 more source
Sulfurous Gases As Biological Messengers and Toxins: Comparative Genetics of Their Metabolism in Model Organisms [PDF]
, 2011 Gasotransmitters are biologically produced gaseous signalling molecules. As gases with potent biological activities, they are toxic as air pollutants, and the sulfurous compounds are used as fumigants.
Ebert, Paul R. +2 more
core +3 more sources
Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver [PDF]
, 2016 Disturbances in protein folding and membrane compositions in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins-PERK (PEK/EIF2AK3), IRE1, and ATF6-is activated by ER stress.
Adams, Christopher M. +7 more
core +1 more source
Unravelling the theories of pre-eclampsia:Are the protective pathways the new paradigm? [PDF]
, 2015 Pre-eclampsia is a vascular disorder of pregnancy where anti-angiogenic factors, systemic inflammation and oxidative stress predominate, but none can claim to cause pre-eclampsia.
Ahmed, Asif, Ramma, Wenda
core +1 more source
Emerging Evidence for Association of Transsulfuration Pathway with Hypoxia Responses [PDF]
When people ascend to a high altitude (HA), the body’s oxygen (O2) sensing mechanisms can sense perturbation in partial pressure and trigger adaptive responses.
Jain, Neha, Sharma, Manish
core +2 more sources
Genetic engineering of mammalian cell lines for improved production of gene therapy viral vectors [PDF]
, 2017 Viral vectors are widely used in gene therapy as vehicles to deliver therapeutic gene cargos. Among the different viral vectors, retroviral and lentiviral vectors are of particular interest due to their ability to sustain long-term stable expression of ...
Vaz, Tiago André Gonçalves
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Epigenetics, Nutrition, and Infant Health [PDF]
, 2018 The field of epigenetics is currently garnering a great deal of interest, exploring how our very molecular makeup in the form of modifications to the genome can be altered by factors as diverse as aging, disease, nutrition, stress, alcohol, and exposure ...
James, P, Prentice, A, Silver, M
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