Results 81 to 90 of about 7,941 (171)

Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics

Prostate Cancer, 2016
Hydrogen sulfide (H2S) was originally considered toxic at elevated levels; however just in the past decade H2S has been proposed to be an important gasotransmitter with various physiological and pathophysiological roles in the body.
Mingzhe Liu, Lingyun Wu, Sabine Montaut, Guangdong Yang   +3 more
doaj   +1 more source

CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway

Frontiers in Pharmacology, 2023
Hydrogen sulfide (H2S), a gasotransmitter with protective effects in the cardiovascular system, is endogenously generated by three main enzymatic pathways: cystathionine gamma lyase (CTH), cystathionine beta synthase (CBS) and 3-mercaptopyruvate ...
Antonia Katsouda, Antonia Katsouda, Maria Markou, Maria Markou, Paraskevas Zampas, Paraskevas Zampas, Aimilia Varela, Constantinos H. Davos, Valentina Vellecco, Giuseppe Cirino, Mariarosaria Bucci, Andreas Papapetropoulos, Andreas Papapetropoulos   +12 more
doaj   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, Volume 13, Issue 31, 4 June 2026.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Methionine Restriction Extends Yeast Lifespan by Activating Non‐Nitrogen‐Starvation‐Induced Autophagy Through Limiting Methylation of Protein Phosphatase 2A

Aging Cell, Volume 25, Issue 6, June 2026.
Methionine restriction extends yeast replicative and chronological lifespan as a consequence of depletion of S‐adenosylmethionine (SAM). SAM depletion leads to demethylation of PP2A and increased phosphorylation of Npr2 which activates non‐nitrogen‐starvation (NNS) induced autophagy; early methionine restriction is sufficient to activate persistent ...
Kaylah Birmingham, Nina Arslanovic, Thea Grauer, Ignacio Gutierrez, Ujani Chakraborty, Simone Sidoli, Jessica Tyler   +6 more
wiley   +1 more source

Influence of sex hormones on DNA content and cystathionine-γ-lyase expression in rat myocardium

Zaporožskij Medicinskij Žurnal, 2017
Till now sexual features of cystathionine-γ-lyase/H2S system functioning in heart and its relationship to DNA content in myocardial cells nuclei depending on the level of sex hormones.
A. V. Melnik , N. V. Zaichko, I. L. Chereshnyuk, О. А. Khodakіvskyi, O. А. Haiduk   +4 more
doaj   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, Volume 604, Issue 11, Page 4247-4260, 1 June 2026.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, Volume 16, Issue 5, Page 944-965, May 2026.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Engineering of methionine-auxotroph Escherichia coli via parallel evolution of two enzymes from Corynebacterium glutamicum's direct-sulfurylation pathway enables its recovery in minimal medium

Metabolic Engineering Communications
Methionine biosynthesis relies on the sequential catalysis of multiple enzymes. Escherichia coli, the main bacteria used in research and industry for protein production and engineering, utilizes the three-step trans-sulfurylation pathway catalyzed by L ...
Matan Gabay, Inbar Stern, Nadya Gruzdev, Adi Cohen, Lucia Adriana-Lifshits, Tamar Ansbacher, Itamar Yadid, Maayan Gal   +7 more
doaj   +1 more source

Decreased mRNA Expression of Cystathionine Gamma lyase and H2S Concentration in Gastric Mucosal Tissue in Diabetic Rats

Brazilian Archives of Biology and Technology, 2018
Background and aim: It is well established that the rate of gastric lesions increases in diabetic rats. Recently, the protective effect of hydrogen sulfide (H2S) in gastric mucosa has been proven. This study aimed to determine the release of H2S and mRNA
Seyyed Ali Mard, Kobra Alinejad Dehkohneh, Akram Ahangarpour   +2 more
doaj   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, Volume 13, Issue 28, 18 May 2026.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source