Results 121 to 130 of about 43,347 (262)

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

Characterisation of two endogenous mammalian cysteine proteinase inhibitors, bovine cystatin C and human cystatin A [PDF]

, 1999
The binding of human cystatin A to papain-like proteinases was quantified with a recombinant inhibitor, expressed in E.coli. The interaction with papain and cathepsin L was strong, with K, values of 10'n-10'13 M, and rapid, with values of 3-5106 M’1*1 ...
Olsson, Sigrid-Lisa
core  

Histidine-rich glycoprotein is evolutionarily related to the cystatin superfamily Presence of two cystatin domains in the N-terminal region

, 1987
A new member of the cystatin superfamily is introduced. Human plasma histidine-rich glycoprotein (HRG) was found to contain 2 cystatin-like sequences in tandem in the N-terminal region.
Odani, Shoji, Koide, Takehiko, Shoji Odani, Takehiko Koide   +3 more
core   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, Volume 100, Issue 1, Page 48-58, July 2026.
[Color figure can be viewed at www.annalsofneurology.org] Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1 ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Serum Cystatin C is Associated with Depression After Intracerebral Hemorrhage

, 2023
Lei Zhu,1,2 Chuanqing Yu,2 Yueyue Chang,2 Shiyu Sun,2 Zhongwu Sun1 1Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 2Department of Neurology, First Affiliated Hospital of ...
Yu C, Zhu L, Sun S, Chang Y, Sun Z
core  

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2028-2048, July 2026.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Quail cystatin: Isolation and characterisation of a new member of the cystatin family and its hypothetical interaction with cathepsin B

, 1997
Quail cystatin, a new cysteine proteinase inhibitor protein of the cystatin superfamily, was purified from egg albumen of Japanese quail Coturnix coturnix japonica.
Mentele, Reinhard, Wittmann, Josef, Christoph Eckerskorn, Helmut J Kolb, Werner Machleidt, Ennes A Auerswald, Gerhartz, Bernd, Richard A Engh, Hans Fritz, Bernd Gerhartz, Eckerskorn, Christoph, Machleidt, Werner, Auerswald, Ennes A, Richardo Torquato, Kolb, Helmut J, Josef Wittmann, Reinhard Mentele, Fritz, Hans, Engh, Richard A, Torquato, Richardo   +19 more
core   +1 more source

Cingulate Gradient Dysfunction in End‐Stage Renal Disease: Associations With Clinical Phenotypes and Exploratory Transcriptomic Signatures

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
End‐stage renal disease (ESRD) patients exhibited significant cingulate gradient dysfunction, which was significantly correlated with multiple functional domains, serum urea, and hemoglobin levels. Spatially, these alterations were correlated with genes enriched in neurodegenerative pathways.
Peng Li, Jun‐Ya Mu, Xin‐Yi Zhu, Hui‐Jie Yuan, Zhao‐Yao Luo, Qian‐Ge Zhu, Xuan Niu, Xiu‐Long Feng, Yu Han, Ting Ge, Chen‐Xi Wang, Wen Wang, Ming Zhang   +12 more
wiley   +1 more source

Cystatin S: Molecular biology and sympathetic innervation

, 1998
The ratsubmandibular glands (SMG) are innervated by both the sympathetic and the parasympathetic branches of the autonomic nervous system which, in turn, regulate the secretory functions of the glands. Parasympathetic innervation of rat SMG is present at
Shaw, Phyllis; Mount Sinai School of Medicine, Chaparro, Orlando; Mount Sinai School of Medicine   +1 more
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Scutellarein Alleviates Ulcerative Colitis by Reshaping Gut Microbiota and Regulating the PRMT1‐Mediated Th17/Treg Balance

Food Frontiers, Volume 7, Issue 4, July 2026.
Scutellarein alleviates ulcerative colitis by reinforcing the intestinal barrier via the microbiota‐metabolite axis and suppressing PRMT1‐STAT3‐mediated inflammatory immune responses. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colonic mucosa with an increasing global burden and limited therapeutic efficacy.
Yefan Zhou, Xinyu Xu, Huan Fang, Xue Wang, Jiaqi Hua, Linping Lu, Dongxu Li, Yangyang Wen, Jieqiong Yao, Fang Liu, Jing He, Fucheng He, Mingxia Zhou   +12 more
wiley   +1 more source