Results 101 to 110 of about 64,052 (260)

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Partial purification of trypsin/papain inhibitors from Hymenaea courbaril L. seeds and antibacterial effect of protein fractions

Hoehnea
The crude extract and protein fractions of Hymenaea courbaril L. seeds were investigated for the presence of trypsin and papain inhibitors and antimicrobial activity against Vibrio parahaemolyticus, Staphylococcus aureus, and Escherichia coli.
Mônica Silva de Brito, Mônica Brandão Melo, Jamille Perdigão de Andrade Alves, Raquel Oliveira dos Santos Fontenelle, Marlene Feliciano Mata, Lúcia Betânia da Silva Andrade   +5 more
doaj   +1 more source

Inverse Relationship between Adherence to the Mediterranean Diet and Serum Cystatin C Levels [PDF]

, 2017
OBJECTIVE: The aim of the present study was to examine serum cystatin C levels in association with the Mediterranean diet in a healthy Greek population.
Avgerinos, PC, Barbetseas, J, Bonou, MS, Bountziouka, V, Evangelopoulos, AA, Georgousopoulou, E, Panagiotakos, DB, Vallianou, NG, Vogiatzakis, ED   +8 more
core   +1 more source

Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Frontiers in Immunology
BackgroundAscaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but ...
Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R. Williams, Luis Caraballo   +7 more
doaj   +1 more source

Increased Cystatin C in Astrocytes of Transgenic Mice Expressing the K670N-M671L Mutation of the Amyloid Precursor Protein and Deposition in Brain Amyloid Plaques

Neurobiology of Disease, 2001
Cystatin C is an essential secretory cofactor for neurogenesis with potent protease inhibitor activities. Polymorphisms of cystatin C are genetically associated with Alzheimer's disease (AD), and the L68Q mutation causes hereditary cerebral hemorrhage ...
Tiana Steinhoff, Eva Moritz, M.Axel Wollmer, M.Hasan Mohajeri, Stefan Kins, Roger M. Nitsch   +5 more
doaj   +1 more source

Unbiased protein association study on the public human proteome reveals biological connections between co-occurring protein pairs [PDF]

, 2017
Mass-spectrometry-based, high-throughput proteomics experiments produce large amounts of data. While typically acquired to answer specific biological questions, these data can also be reused in orthogonal wayS to reveal new biological knowledge.
Gupta, Surya, Verheggen, Kenneth, Tavernier, Jan, Martens, Lennart   +3 more
core   +2 more sources

Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on

Acta Ophthalmologica, EarlyView.
Abstract Purpose The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long‐term outcome and the incidence of complications such as chronic kidney disease (CKD).
Jytte Hendrikse, Anne Sina Paula Simon, Viera Kalinina Ayuso, Joke Helena de Boer, Gerrit van den Berg   +4 more
wiley   +1 more source

Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum conjugated primary bile acids accumulate in alcohol‐related hepatitis due to downregulation of hepatocyte bile acid transporters. Hepatocyte growth factor is elevated in alcohol‐related hepatitis and downregulates BSEP expression. This detrimentally affects the hepatoprotective adaptive reduction in NTCP/increase in BSEP seen in cholestasis ...
Luke D. Tyson, Stephen Atkinson, Benjamin H. Mullish, Alexandros Pechlivanis, Michael Allison, Andrew Austin, Katie Chappell, Stuart J. Forbes, Ewan H. Forrest, Alastair M. Kilpatrick, Tong Liu, Laura Martinez‐Gili, Steven Masson, Mark J. W. McPhail, Joao Nunes, Paul Richardson, Daniel Rodrigo‐Torres, Stephen D. Ryder, Mark Wright, Vishal C. Patel, Nikhil Vergis, Elaine Holmes, Mark R. Thursz   +22 more
wiley   +1 more source

Kadar Cystatin-C Serum Sebagai Penanda Fungsi Ginjal Bayi Prematur

Sari Pediatri, 2016
Latar belakang. Cystatin-C dipertimbangkan menjadi pemeriksaan potensial pengganti kreatinin serum sebagai penanda fungsi ginjal. Kadar cystatin-C serum lebih mendekati nilai laju filtrasi glomerulus dibandingkan dengan kreatinin serum.
Dinna Meinardaniawati, Sjarif Hidajat Effendi, Sri Endah Rahayuningsih   +2 more
doaj   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source