Results 131 to 140 of about 55,204 (241)

Differential Organ Ageing Is Associated With Age‐Related Macular Degeneration

Aging Cell, Volume 24, Issue 5, May 2025.
Using the UK Biobank, this study trained neural networks to estimate the biological age of individuals according to markers of organ function. Computing the difference between the estimated organ age and chronological age yielded an estimate for accelerated or slowed ageing.
Anastasios Papadam, Arimantas Lionikas, Felix Grassmann   +2 more
wiley   +1 more source

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments

Aging Cell, EarlyView.
The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel, J. Candia, C. Ubaida‐Mohien, T. Tanaka, A. Z. Moore, M. Zhu, G. Fantoni, S. Church, J. D'Agostino, J. Fan, N. Shehadeh, S. De, E. Lehrmann, M. Kaileh, E. Simonsick, R. Sen, J. M. Egan, L. Ferrucci   +17 more
wiley   +1 more source

A barley cystatin stably expressed in rice exhibits strong in vitro inhibitory activity against gut proteinases of rice water weevil

Biotecnología Aplicada
Rice water weevil, Lissorhoptrus brevirostris Suffrian (Coleoptera: Curculionidae), is one of the most important rice pests in Cuba. Here, we describe the production of transgenic rice plants expressing barley cystatin HvCPI-1 (Icy1 gene) to explore the ...
Raúl Armas, Carlos Hernández, Daymi Abreu, Maylin Pérez, Yeosvany Cabrera, Merardo Pujol, Julio Alfonso-Rubi   +6 more
doaj  

Identifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study

Aging Cell, EarlyView.
Integration of multi‐omics analyses reveals PDAP1 as one of the key regulators of longevity and aging. Mendelian randomization, colocalization, prospective studies, and in vitro experiments highlight PDAP1's effects on mortality, lifespan, and cellular senescence.
Tianzhichao Hou, Zimo Sha, Qi Wang, Yuanyue Zhu, Zheng Zhu, Huajie Dai, Yijie Zhu, Tiange Wang, Mian Li, Zhiyun Zhao, Yu Xu, Jieli Lu, Jie Zheng, Jing Ye, Weiqing Wang, Guang Ning, Yufang Bi, Weiguo Hu, Min Xu   +18 more
wiley   +1 more source

The Lipidomic Profile Discriminates Between MASLD and MetALD

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 8, Page 1357-1371, April 2025.
HDL‐centric lipidomic biomarkers, particularly within large and medium HDL subfractions, distinguish metabolic dysfunction and alcohol‐related liver disease from metabolic dysfunction‐associated steatotic liver disease, suggesting potential biomarkers for clinical differentiation.
Kai Markus Schneider, Feng Cao, Helen Ye Rim Huang, Lanlan Chen, Yazhou Chen, Rongpeng Gong, Anastasia Raptis, Kate Townsend Creasy, Jan Clusmann, Felix van Haag, Paul‐Henry Koop, Adrien Guillot, Tom Luedde, Rohit Loomba, Sven Francque, Carolin Victoria Schneider   +15 more
wiley   +1 more source

Production and Functional Verification of 8‐Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)‐Edited Donor Pigs for Xenotransplantation

Cell Proliferation, EarlyView.
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang, Kaixiang Xu, Tao Liu, Heng Zhao, Muhammad Ameen Jamal, Gen Chen, Xiaoying Huo, Chang Yang, Deling Jiao, Taiyun Wei, Hanfei Huang, Hongfang Zhao, Jianxiong Guo, Fengchong Wang, Xiong Zhang, Kai Liu, Siming Qu, Gang Wang, Hui Guo, Gang Chen, Hong‐Ye Zhao, Zhong Zeng, Kefeng Dou, Hong‐Jiang Wei   +23 more
wiley   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

Longitudinal Study of Renal Health Screening in Apparently Healthy Aging Dogs. [PDF]

J Vet Intern Med
ABSTRACT Background Combined measurement of functional, glomerular, and tubular markers in aging dogs is essential to detect early renal disease. Objectives Prospective longitudinal study to describe renal function and assess which biomarkers are associated with the development of early renal disease or death.
Marynissen S, Daminet S, Meyer E, Demeyere K, Stock E, Delanghe J, Duchateau L, Paepe D.   +7 more
europepmc   +2 more sources

Multidimensional insights about healthy aging from the cohort study for community‐dwelling older adults: The SONIC study

Geriatrics &Gerontology International, Volume 25, Issue 3, Page 346-355, March 2025.
The Septuagenarian, Octogenarian, Nonagenarian Investigation with Centenarian (SONIC) study was established considering population trends and targeting the oldest‐old population. This study is unique in its narrow age range, consisting of individuals aged in their 70s, 80s and 90s, and is carried out as a longitudinal cohort study with follow ups every
Kei Kamide, Kazunori Ikebe, Yukie Masui, Takeshi Nakagawa, Mai Kabayama, Hiroshi Akasaka, Tomoaki Mameno, Yuki Murotani, Madoka Ogawa, Saori Yasumoto, Koichi Yamamoto, Takumi Hirata, Yasumichi Arai, Yasuyuki Gondo, the SONIC study group, Hiromi Rakugi, Ken Sugimoto, Ryosuke Oguro, Ada Congrains, Tatsuo Kawai, Hiroshi Kusunoki, Chikako Nakama, Miyuki Onishi‐Takeya, Yasushi Takeya, Hiroko Hanasaki‐Yamamoto, Yoichi Takami, Serina Yokoyama, Satomi Maeda, Motonori Nagasawa, Taku Fujimoto, Yoichi Nozato, Yuri Onishi, Ken Terashima, Shino Yoshida, Ryoichi Ohara, Masaaki Isaka, Kayo Godai, Michiko Kido, Yuya Akagi, Hirochika Ryuno, Eri Kiyoshige, Tomoko Noma, Kentaro Tanaka, Werayuth Srithumsuk, Nonglak Klinpudtan, Jinmei Tuo, Toshiaki Sekiguchi, Yuko Nakamura, Toshiki Mizuno, Tomoko Yano, Weng Fang, Yuka Ohata, Yuka Tachibana, Mariko Hosokawa, Arisa Wada, Hiroko Yoshida, Saya Terada, Takako Inoue, Yasuka Sawayama, Naoko Wada, Atsuko Higuchi, Chizuru Kuruma, Atsuto Hirose, Hitomi Tsunai, Yurie Maeyama, Keigo Kobayashi, Ayano Tamura, Motoko Nogami, Mayuka Iguchi, Mio Kubo, Minori Eguchi, Haruna Kikuchi, Riko Kinjo, Ayaka Hiratsuka, Yui Toshimitsu, Kaoru Hatta, Chisato Hori, Maya Mitani, Reina Yokokawa, Yoshinobu Maeda, Sinya Murakami, Kodai Hatta, Chisato Inomata, Yusuke Mihara, Motoyoshi Fukutake, Tadashi Okada, Hajime Takeshita, Sayaka Tada, Masahiro Uota, Masaki Yoshinaka, Taiji Ogawa, Masahiro Kitamura, Koji Miki, Hitomi Sato, Kotaro Higashi, Eri Seto, Suzuna Akema, Satoshi Sasaki, Hitomi Okubo, Ayaka, Kasuga, Yoshiko Ishioka, Kiyoaki Matumoto, Giovanni Sala, Hwang Choe, Hiroyuki Muto, Kumi Hirokawa, Yumi Kimura, Kokoro Shirai, Keitaro Numata, Megumi Tabuchi, Yukiko Tatsuhira, Marina Kozon, Fumika Goto, Yuki Mino, Akari Kikuchi, Xinyu Zhang, Yuchun Tsai, Yutian Cheng, Can Wang, Chihiro Nakajima, Yumi Tsuji, Momoho Kakuta, Nao Sakaguti, Marin Fujii, Momoko Furuno, Sayo Iio, Chihana Izuriha, Yuko Masuda, Yuki Matsubara, Takuto Nakanishi, Eriko Tasaka, Meina Tsujikura, Kazuko Yasumura, Tatsuro Ishizaki, Ryutaro Takahashi, Tamao Endo, Shuichi Awata, Kae Ito, Yuri Miura, Hiroki Inagaki, Yuko Yoshida, Hiroki Tsumoto, Keitaro Umezawa, Kyojiro Kawakami, Mayuko Ono, Noriko Hori, Takeshi Kurinobu, Wataru Onoguchi, Fumi Yoshimatsu, Takuro Okuyama, Nobuyoshi Hirose, Michiyo Takayama, Yukiko Abe   +153 more
wiley   +1 more source

How to estimate GFR in children [PDF]

, 2009
Delanghe, Joris
core   +1 more source