Results 11 to 20 of about 43,347 (262)

Salivary proteome profile of women during fertile phase of menstrual cycle as characterized by mass spectrometry

Gynecology and Minimally Invasive Therapy, 2021
Objectives: Ovulation is such a critical physiological process that its noninvasive detection based on salivary constituents has several advantages in humans.
Ganesan Saibaba, Durairaj Rajesh, Subramanian Muthukumar, Ganesan Sathiyanarayanan, Archunan Priya Aarthy, Govindaraju Archunan   +5 more
doaj   +1 more source

Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens

Vaccines, 2021
Poultry red mite (PRM; Dermanyssus gallinae) is a hazardous, blood-sucking ectoparasite of birds that constitutes a threat to poultry farming worldwide.
Sotaro Fujisawa, Shiro Murata, Masayoshi Isezaki, Takuma Ariizumi, Takumi Sato, Eiji Oishi, Akira Taneno, Naoya Maekawa, Tomohiro Okagawa, Osamu Ichii, Satoru Konnai, Kazuhiko Ohashi   +11 more
doaj   +1 more source

Stefin B Inhibits NLRP3 Inflammasome Activation via AMPK/mTOR Signalling

Cells, 2023
Stefin B (cystatin B) is an inhibitor of lysosomal and nuclear cysteine cathepsins. The gene for stefin B is located on human chromosome 21 and its expression is upregulated in the brains of individuals with Down syndrome.
Mojca Trstenjak-Prebanda, Monika Biasizzo, Klemen Dolinar, Sergej Pirkmajer, Boris Turk, Veronique Brault, Yann Herault, Nataša Kopitar-Jerala   +7 more
doaj   +1 more source

Diagnostic and prognostic performance of urinary neutrophil gelatinase‐associated lipocalin in patients with cirrhosis and acute kidney injury

Hepatology, EarlyView., 2022
Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino, Salvatore Piano, Matteo Stenico, Marta Tonon, Alessandra Brocca, Valeria Calvino, Simone Incicco, Nicola Zeni, Roberta Gagliardi, Chiara Cosma, Martina Zaninotto, Patrizia Burra, Umberto Cillo, Daniela Basso, Paolo Angeli   +14 more
wiley   +1 more source

Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis [PDF]

, 2022
Cystatin C is a specific biomarker of kidney function. We perform this meta-analysis to determine the association of Cystatin C with the COVID-19 severity. In this systematic review and meta-analysis, we searched PubMed, EMBASE, Cochrane library, and Web
Peacock, Frank W, Raúl Júarez-Vela, Lukasz Jankowski, Jankowski, Lukasz, Matuszewski, Michal, Michal Matuszewski, Navolokina, Alla, Júarez-Vela, Raúl [0000-0003-3597-2048], Pruc, Michal, Lukasz Szarpak, Rafique, Zubaid, Yurii Reznikov, Michal Pruc, Peacock, Frank W., Júarez-Vela, Raúl, Frank W. Peacock, Alla Navolokina, Zubaid Rafique, Reznikov, Yurii, Szarpak, Lukasz   +19 more
core   +1 more source

Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of ‘Papain Superfamily’ Cysteine Proteases

Pharmaceuticals, 2020
Clan C1A or ‘papain superfamily’ cysteine proteases are key players in many important physiological processes and diseases in most living systems. Novel approaches towards the development of their inhibitors can open new avenues in translational medicine.
Manasi Mishra, Vigyasa Singh, Meenakshi B. Tellis, Rakesh S. Joshi, Shailja Singh   +4 more
doaj   +1 more source

Comparative transcriptomic analysis-based identification of the regulation of foreign proteins with different stabilities expressed in Pichia pastoris

Frontiers in Microbiology, 2022
IntroductionThe industrial yeast Pichia pastoris is widely used as a cell factory to produce proteins, chemicals and advanced biofuels. We have previously constructed P. pastoris strains that overexpress protein disulfide isomerase (PDI), which is a kind
Tingting Niu, Yi Cui, Xu Shan, Shuzhen Qin, Xuejie Zhou, Rui Wang, Alan Chang, Nan Ma, Jingjing Jing, Jianwei He   +9 more
doaj   +1 more source

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]

, 2001
Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Gross, Stefan, Machleidt, Werner, Assfalg-Machleidt, Irmgard, Pfeiler, Dietmar, Gabrijelcic-Geiger, Dusica, Gollmitzer, Nicole, García Diaz, Beatriz, Auerswald, Ennes A., Stubbs, Milton T., Fritz, Hans   +9 more
core   +1 more source

Upregulation of Mitochondrial Redox Sensitive Proteins in LPS-Treated Stefin B-Deficient Macrophages

Cells, 2019
Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht−Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism
Mojca Trstenjak Prebanda, Janja Završnik, Boris Turk, Nataša Kopitar Jerala   +3 more
doaj   +1 more source

Bioinformatics analysis and prokaryotic expression of a cystatin analogue from Spirometra erinaceieuropaei

Biotechnology & Biotechnological Equipment, 2023
Cystatin plays a crucial role in immune evasion by parasites. It regulates diverse immune response processes, such as antigen presentation, cytokine and NO production, and phagocytosis.
Lin Huang, Ling Mai, Gang Lv, Xinjun Chen   +3 more
doaj   +1 more source