Results 31 to 40 of about 64,052 (260)

Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V

Frontiers in Genetics, 2021
Keratosis follicularis spinulosa decalvans (KFSD) is a rare cornification disorder with an X-linked recessive inheritance in most cases. Pathogenic variants causing X-linked KFSD have been described in MBTPS2, the gene for a membrane-bound zinc ...
Katja M. Eckl, Robert Gruber, Louise Brennan, Andrew Marriott, Roswitha Plank, Roswitha Plank, Verena Moosbrugger-Martinz, Stefan Blunder, Anna Schossig, Janine Altmüller, Holger Thiele, Peter Nürnberg, Johannes Zschocke, Hans Christian Hennies, Hans Christian Hennies, Matthias Schmuth   +15 more
doaj   +1 more source

Identification of Proteins Responsible for High Activity of Cysteine Proteinase Inhibitor in the Blood of Nile Tilapia Oreochromis niloticus

Fishes, 2022
Cysteine proteinase inhibitors (CPIs) protect tissues and organs against cysteine proteinases in animal blood and have attracted much attention for use in food processing and medical sciences for humans and animals.
Seong Hee Mun, Joon Yeong Kwon
doaj   +1 more source

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]

, 2001
Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Anastasi A., Björk I., Bode W., Bradford H. N., Crawford C., Crawford C., Emori Y., Kawasaki H., Ma H., Maki M., Maki M., Mason R. W., Salvesen G., Sorimachi H., Stubbs M. T.   +14 more
core   +1 more source

Overexpression of StCYS1 gene enhances tolerance to salt stress in the transgenic potato (Solanum tuberosum L.) plant

Journal of Integrative Agriculture, 2020
Salt stress seriously restricts the growth and yield of potatoes. Plant cystatins are vital players in biotic stress and development, however, their roles in salt stress resistance remain elusive.
Min-min LIU, Ya-lun LI, Guang-cun LI, Tian-tian DONG, Shi-yang LIU, Pei LIU, Qing-guo WANG   +6 more
doaj   +1 more source

Association of urinary uromodulin with kidney function decline and mortality: the health ABC study
. [PDF]

, 2017
BackgroundUrine uromodulin (uUMOD) is a protein secreted by the kidney tubule. Recent studies have suggested that higher uUMOD may be associated with improved kidney and mortality outcomes.MethodsUsing a case-cohort design, we evaluated the association ...
Bennett, Michael R, Devarajan, Prasad, Fried, Linda F, Garimella, Pranav S, Gutiérrez, Orlando M, Harris, Tamara B, Ix, Joachim H, Katz, Ronit, Kritchevsky, Stephen B, Parikh, Chirag R, Sarnak, Mark J, Shlipak, Michael G   +11 more
core   +1 more source

Bone mineral density and risk of heart failure in older adults: The Cardiovascular Health Study [PDF]

, 2017
Background Despite increasing evidence of a common link between bone and heart health, the relationship between bone mineral density ( BMD ) and heart failure ( HF
Bartz, Traci M, Brown, David L, Carbone, Laura D, Chaves, Paulo H.M., Civitelli, Roberto, Fohtung, Raymond B, Kestenbaum, Bryan R, Kizer, Jorge R, Koh, William J.H., Stein, Phyllis K   +9 more
core   +2 more sources

Melia azedarach L. extract induced the production of phytocystatin in passion fruit leaves

Hoehnea, 2021
Phytocystatins belong to the family of cysteine proteinases inhibitors. These proteinase inhibitors have crucial functions in plant defense against insects and pathogens attack. In the present study Melia azedarach L. extract acts as an elicitor of plant
Alyne Bispo Rodrigues, César Luis Siqueira Junior   +1 more
doaj   +1 more source

Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C Level

Mustansiriya Medical Journal
Background: Preeclampsia (PE) is a major health problem that increases the risk of renal impairment during pregnancy. Studies have described the utility of Cystatin C as a better indicator of kidney function during pregnancy compared to urea, creatinine,
Marwa Basim Yarmurad, Miami Abdul Hassan Ali   +1 more
doaj   +1 more source

An Immunosuppressive Tick Salivary Gland Protein DsCystatin Interferes With Toll-Like Receptor Signaling by Downregulating TRAF6

Frontiers in Immunology, 2018
Ticks, blood-feeding arthropods, and secrete immunosuppressive molecules that inhibit host immune responses and provide survival advantages to pathogens.
Ta Sun, Fanqi Wang, Wen Pan, Qihan Wu, Jingwen Wang, Jianfeng Dai   +5 more
doaj   +1 more source

Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology [PDF]

, 2017
Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world.
Fleming, John O., Maizels, Richard, Varyani, Fumi   +2 more
core   +1 more source