Results 51 to 60 of about 64,052 (260)

Human μ-calpain: Simple isolation from erythrocytes and characterization of autolysis fragments [PDF]

, 2001
Heterodimeric μ-calpain, consisting of the large (80 kDa) and the small (30 kDa) subunit, was isolated and purified from human erythrocytes by a highly reproducible four-step purification procedure.
Crawford C., Croall D. E., Graham-Siegenthaler K., Guroff G., Kitahara A., McClelland P., Nishimura T., Sasaki T., Sorimachi H., Sorimachi H., Sorimachi H., Thompson V.F., Yoshimura N., Zimmermann U.J.P.   +13 more
core   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection. [PDF]

, 2016
Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for ...
Cao, Cheng-Xi, Fan, Liu-Yin, Kim, Jae Joon, Kim, Kyoung Mee, Kim, Sung, Kim, Yong, Wong, David TW, Xiao, Hua, Yoshizawa, Janice, Zhang, Yan   +9 more
core   +5 more sources

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin

Frontiers in Cellular and Infection Microbiology, 2020
Schistosomula (the post-infective stages) of the neurotropic schistosome Trichobilharzia regenti possess multiple isoforms of cathepsin B1 peptidase (TrCB1.1-TrCB1.6) with involvement in nutrient digestion.
Hana Dvořáková, Roman Leontovyč, Tomáš Macháček, Anthony J. O'Donoghue, Ondřej Šedo, Zbyněk Zdráhal, Charles S. Craik, Conor R. Caffrey, Petr Horák, Libor Mikeš   +9 more
doaj   +1 more source

Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways. [PDF]

PLoS ONE, 2009
Cystatin C is believed to prevent tumor progression by inhibiting the activities of a family of lysosomal cysteine proteases. However, little is known about the precise mechanism of cystatin C function in prostate cancer.
Barbara Wegiel, Thomas Jiborn, Magnus Abrahamson, Leszek Helczynski, Leo Otterbein, Jenny Liao Persson, Jenny Liao Persson, Anders Bjartell   +7 more
doaj   +1 more source

Breeding drought tolerant cowpea: constraints, accomplishments, and future prospects [PDF]

, 2009
This review presents an overview of accomplishments on different aspects of cowpea breeding for drought tolerance. Furthermore it provides options to enhance the genetic potential of the crop by minimizing yield loss due to drought stress. Recent efforts
Agbicodo, A.C.M.E., Fatokun, C.A., Linden, C.G., van der, Muranaka, S., Visser, R.G.F.   +4 more
core   +2 more sources

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

Serum Cystatin C Levels Are Associated With Obesity in Adolescents Aged 14–17 Years

Frontiers in Endocrinology, 2022
BackgroundThe association between serum cystatin C levels and obesity has not been fully explored in adolescents. This study aimed to explore the association between serum cystatin C levels and obesity in adolescents of different sexes.MethodsWe ...
Ying-Xiang Huo, Wei Wei, Yang Liu, Ya-Nan Ma, Jun-Min Tao, Ning-Ning Wang, Xiao-Feng Li, Xin Chen   +7 more
doaj   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats. [PDF]

PLoS ONE, 2017
Cystatin C, a marker of kidney injury, is freely filtered in the glomeruli and reabsorbed by the proximal tubules. Megalin and cubilin are endocytic receptors essential for reabsorption of most filtered proteins.
Danny Jensen, Casper Kierulf-Lassen, Marie Louise Vindvad Kristensen, Rikke Nørregaard, Rikke Nørregaard, Kathrin Weyer, Rikke Nielsen, Erik Ilsø Christensen, Henrik Birn   +8 more
doaj   +1 more source